31753-19-2

Basic information

• Product Name: Prostaglandin A2 methyl ester
• Synonyms: Prostaglandin A2 methyl ester;Prostaglandin A2 methyl ester Exclusive;HVBMOWIJGLUCFB-PMPHTVEESA-N
• CAS NO: 31753-19-2
• Molecular Formula: C₂₁H₃₂O₄
• Molecular Weight: 348.47638
• Mol File: 31753-19-2.mol

Chemical Properties

• Boiling Point: 477.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.060±0.06 g/cm3(Predicted)
• PKA: 14.36±0.20(Predicted)
• CAS DataBase Reference: Prostaglandin A2 methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Prostaglandin A2 methyl ester(31753-19-2)
• EPA Substance Registry System: Prostaglandin A2 methyl ester(31753-19-2)

Safety Data

• Hazardous Substances Data: 31753-19-2(Hazardous Substances Data)

Upstream product

• 13345-50-1 prostaglandin A₂ 
• 31660-11-4 7-[(2S,3S)-3-Hydroxy-2-((E)-(R)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-hept-5-ynoic acid methyl ester 
• 31753-11-4 7-[(1R,5S,6R)-6-(1,2-Bis-methanesulfonyloxy-heptyl)-3-oxo-bicyclo[3.1.0]hex-2-yl]-hept-5-ynoic acid methyl ester 
• 31767-40-5 7-[(1R,5S,6R)-6-(1,2-Dihydroxy-heptyl)-3-oxo-bicyclo[3.1.0]hex-2-yl]-hept-5-ynoic acid methyl ester 
• 31753-05-6 7-[(1R,5R,6R)-6-((Z)-Hept-1-enyl)-3-oxo-bicyclo[3.1.0]hex-2-yl]-hept-5-ynoic acid methyl ester 
• 31703-58-9 2-<(7-Iodo-5-heptynyl)oxy>-2H-tetrahydropyran 
• 31776-12-2 methyl 7-iodohept-5-ynoate 
• 23453-26-1 (Z)-7-[(2S,3S)-3-Hydroxy-2-((E)-(R)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-hept-5-enoic acid methyl ester 
• 77506-99-1 Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-<methylamino>-8-(phenylsulfonyl)-5,13-prostadienoate 
• 85453-58-3 Methyl (5Z,13E,8R,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(anti-oximino)-8-(phenylsulfonyl)-5,13-prostadienoate 
• 77506-98-0 Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(dimethylamino)-8-(phenylsulfonyl)-5,13-prostadienoate 
• 77494-47-4 Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(methylamino)-8-(phenylsulfonyl)-5,13-prostadienoate 
• 74-88-4 methyl iodide 
• 85453-69-6 Methyl (5Z,13E,8R,11R,12R,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(anti-oximino)-5,13-prostadienoate 

Downstream Products

• 78407-39-3 7-[(1R,2S,3R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-3-phenyl-cyclopentyl]-heptanoic acid ethyl ester 
• 81424-30-8 7-[(1R,2S,3R)-2-((E)-3-Hydroxy-oct-1-enyl)-5-oxo-3-phenyl-cyclopentyl]-heptanoic acid ethyl ester 
• 81424-28-4 7-[(1R,2S,3R)-5-Oxo-2-((E)-3-oxo-oct-1-enyl)-3-phenyl-cyclopentyl]-heptanoic acid ethyl ester 
• 81424-58-0 7-{(1R,2S,3R)-5-Oxo-3-phenyl-2-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentyl}-heptanoic acid methyl ester 
• 81424-57-9 (Z)-7-{(1R,2S,3R)-5-Oxo-3-phenyl-2-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentyl}-hept-5-enoic acid methyl ester 
• 87727-97-7 (1S,3R,4R,5R)-4-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentane-1,3-diol 
• 87692-43-1 (1S,3R,4R,5R)-4-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[(Z)-3-(4-methoxy-phenyl)-allyl]-cyclopentane-1,3-diol 
• 87692-35-1 (2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone 
• 87727-95-5 (2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(Z)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone 
• 87727-98-8 (1S,3R,4R,5R)-4-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentane-1,3-diol 
• 87692-44-2 (1S,3R,4R,5R)-4-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-[(Z)-3-(4-methoxy-phenyl)-allyl]-cyclopentane-1,3-diol 
• 87692-33-9 (1S,2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanol 
• 87727-93-3 (1S,2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(Z)-3-(4-methoxy-phenyl)-allyl]-cyclopentanol 
• 87692-34-0 (1S,2R,3R)-3-((E)-(S)-3-Hydroxy-oct-1-enyl)-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanol 

Relevant articles and documents

Identification of a crucial substructural unit for thromboxane A2 receptor binding

A stereospecific synthesis of the 9α,10α-epoxyprostanoic acid derivative 3, a potent and stable mimic of thromboxane A2, is described.

Chemical transformation of prostaglandin-A2: A novel series of C-10 halogenated, C-12 hydroxylated prostaglandin-A2 analogues

Synthesis of a novel class of C-10 halogenated and C-12 oxygenated prostaglandin-A2 derivatives (6a-6c) has been accomplished. (15S)-Prostaglandin-A2 (1), from the gorgonian Plexaura homomalla, served as the starting material for the synthesis. The absolute configuration was determined using NMR.

Synthesis of Aromatic Modified Prostaglandins from PGA2

A general synthetic scheme, starting from PGA2 (obtained from the marine coral Plexaura homomalla), of prostaglandins modified in the upper chain is detailed.Key aldehyde intermediates have been secured from 11-deoxy-PGF2α and PGF2α by an efficient regioselective hydroxylation procedure followed by cleavage of the 5,6-double bond.Witting reaction with these aldehydes provided the novel prostaglandins (5)-(8), belonging to the E and F families, and containing an aromatic ring in the upper chain.

A Triply Convergent Total Synthesis of L-(-)-Prostaglandin E2

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