3221-20-3

Basic information

• Product Name: 2-(4-BENZYL-PIPERAZIN-1-YL)-ETHANOL
• Synonyms: 2-(4-BENZYL-PIPERAZIN-1-YL)-ETHANOL;AKOS 93671;AKOS BB-6103
• CAS NO: 3221-20-3
• Molecular Formula: C₁₃H₂₀N₂O
• Molecular Weight: 220.31
• Mol File: 3221-20-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 200 °C(Press: 0.3 Torr)
• Appearance: /
• Density: 1.090±0.06 g/cm3(Predicted)
• PKA: 14.96±0.10(Predicted)
• CAS DataBase Reference: 2-(4-BENZYL-PIPERAZIN-1-YL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BENZYL-PIPERAZIN-1-YL)-ETHANOL(3221-20-3)
• EPA Substance Registry System: 2-(4-BENZYL-PIPERAZIN-1-YL)-ETHANOL(3221-20-3)

Safety Data

• Hazardous Substances Data: 3221-20-3(Hazardous Substances Data)

Usage

Uses

4-Benzyl-1-piperazineethanol can be used to treat dermatological conditions.

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 141-43-5 ethanolamine 
• 100-39-0 benzyl bromide 
• 75-21-8 oxirane 
• 2759-28-6 1-phenylmethylpiperazine 

Downstream Products

• 141312-27-8 (2-Heptyloxy-phenyl)-carbamic acid 2-(4-benzyl-piperazin-1-yl)-ethyl ester; hydrochloride 
• 110627-20-8 1H-indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl 2-(4-benzyl-1-piperazinyl)ethyl ester 
• 4553-21-3 2-(4-benzylpiperazin-1-yl)-ethylamine 
• 1250224-63-5 2-(4-benzylpiperazin-1-yl)acetaldehyde 
• 84597-68-2 1-benzoyloxy-2-piperazino-ethane; dihydrochloride 
• 144027-90-7 2-(1-piperazinyl)ethyl 2-(4-isobutylphenyl)propionate dihydrochloride 
• 110627-21-9 [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid 2-piperazin-1-yl-ethyl ester 
• 97460-20-3 1H-indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl 2-<4-(3-hydroxypropyl)-1-piperazinyl>ethyl ester 

Relevant articles and documents

C-3 NOVEL TRITERPENONE WITH C-28 UREA DERIVATIVES AS HIV INHIBITORS

The present invention relates to C-3 novel triterpenone with C-28 urea derivatives of formula (I); or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, W, J and X are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) useful for the treatment of viral diseases and particularly HIV mediated diseases.

Indazole derivatives having monocyclic amine

An indazole compound having the formula (I): wherein: R1 is hydrogen, C1 -C6 alkyl, C3 -C6 alkenyl or C3 -C6 cycloalkyl; Q is carbonyl, thiocarbonyl or methylene; and R2 is a group of the formula (II) or (IV); STR1 wherein R1 is C1 -C6 alkyl, C3 -C6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT4 receptor agonist activity.

Ester and amide prodrugs of ibuprofen and naproxen: Synthesis, anti- inflammatory activity, and gastrointestinal toxicity

Ester and amide prodrugs of ibuprofen (1) and naproxen (16) were synthesized and evaluated for anti-inflammatory activity and gastrointestinal toxicity. The chemical structure of the prodrugs was varied in terms of lipophilicity and reactivity toward hydr