3275-13-6

Basic information

• Product Name: 1-(Ethoxymethyl)piperidine
• Synonyms: 1-(Ethoxymethyl)piperidine
• CAS NO: 3275-13-6
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.2267
• Mol File: 3275-13-6.mol

Chemical Properties

• Boiling Point: 173.5°Cat760mmHg
• Flash Point: 47.7°C
• Appearance: /
• Density: 0.906g/cm³
• Vapor Pressure: 1.26mmHg at 25°C
• Refractive Index: 1.448
• PKA: 8.84±0.10(Predicted)
• CAS DataBase Reference: 1-(Ethoxymethyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Ethoxymethyl)piperidine(3275-13-6)
• EPA Substance Registry System: 1-(Ethoxymethyl)piperidine(3275-13-6)

Safety Data

• Hazardous Substances Data: 3275-13-6(Hazardous Substances Data)

Usage

Chemical structure

Piperidine derivative with an ethoxy group attached to the methyl group

Common uses

Building block in the synthesis of pharmaceuticals and agrochemicals

Potential applications

Development of new drugs in medicinal chemistry

Additional uses

Reagent in organic synthesis and possible applications in industrial processes

Safety precautions

Handle with care and follow proper safety measures due to potential hazards

InChI:InChI=1/C8H17NO/c1-2-10-8-9-6-4-3-5-7-9/h2-8H2,1H3

Upstream product

• 110-89-4 piperidine 
• 50-00-0 formaldehyd 
• 64-17-5 ethanol 

Downstream Products

• 77802-91-6 4-nitro-2-(piperidin-1'-ylmethyl)phenol 
• 73477-71-1 1-(octylmercapto-methyl)-piperidine 
• 7352-03-6 N-(ethoxymethyl)diethylamine 
• 6638-91-1 2-piperidinomethylene-1-naphthol 
• 500859-97-2 4-hydroxy-3-(piperidin-1-ylmethyl)benzaldehyde 
• 70500-83-3 5-methyl-2-piperidin-1-ylmethyl-phenol 
• 68097-75-6 2-methyl-4-piperidin-1-ylmethyl-phenol 
• 13704-50-2 4-chloro-2-piperidin-1-ylmethyl-phenol 
• 104126-73-0 4-chloro-3-piperidinomethyl-phenol 
• 5342-95-0 1-piperidin-1-ylmethyl-naphthalen-2-ol 
• 20276-55-5 N-methylenepiperidinium chloride 
• 68097-97-2 6-(N-piperidinylmethyl)-2,5-dimethylphenol 
• 68097-99-4 4,6-bis(N-piperidinylmethyl)-2,5-dimethylphenol 
• 68097-96-1 1-<(4-Hydroxy-3,6-dimethyl-phenyl)-methyl>-piperidin 

Relevant articles and documents

Synthesis of ditopic ligands for the selective extraction of copper(II) nitrate and crystal structures of their Cu(II) complexes

We have synthesized two ditopic ligands for selective extraction of copper(II) nitrate. We also synthesized one cation-only binding analog for comparison. All three ligands were characterized by conventional techniques. Competitive two-phase metal ion sol

The generation of iminium ions using chlorosilanes and their reactions with electron rich aromatic heterocycles

Dichlorodimethylsilane and trichloromethylsilane have been used to generate iminium ions from aminals and aminol ethers derived from secondary alkylamines, including glycine derivatives, in aprotic media which were shown to undergo reactions with electron rich aromatic heterocycles, including furan, to give mono-aminoalkylation products in good yields. Whereas chlorotrimethylsilane has been shown to generate iminium ions from aminol ethers, no evidence was adduced for the involvement of iminium ions using aminals. 2,5-Disubstitution of N-methylpyrrole was the major result in reactions of N-methylpyrrole with aminals in the presence of chlorotrimethylsilane where no build up of hydrogen chloride occurs and where chlorotrimethylsilane can function catalytically. Experimental results, including the use of bis(trimethylsilyl)acetamide as a proton scavenger, and some relative rate data, are presented that allow possible mechanisms to be evaluated.

A New Convenient Synthesis of Dialkyl(methylene)ammonium Chloride

A new, convenient synthesis of dialkyl(methylene)ammonium chloride is proposed from gem-aminoethers and methyltrichlorosilane, a by-product of the industrial methylchlorosilane synthesis.

The synthesis of α-amino-substituted diphenylphosphine oxides

Four methods with differing but overlapping specificity are described for the synthesis of α-unsubstituted as well as α-substituted (aminomethyl)diphenylphosphine oxides.The first method is based on the Arbusov reaction, the second on a Mannich-type condensation of diphenylphosphine oxide with aldehydes and secondary amines, the third on the addition of Ph2P(O)H to enamines and the fourth on the reaction of anions derived from α-unsubstituted (aminomethyl)diphenylphosphine oxides with various electrophiles.