328-72-3

Basic information

• Product Name: 3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE
• Synonyms: 5-chloro-1,3-bis(trifluoromethyl)-benzene;benzene,5-chloro-1,3-bis(trifluoromethyl)-;bistrifluoromethylchlorobenzene;1-CHLORO-3,5-BIS(TRIFLUOROMETHYL)BENZENE;3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE;3,5-BIS(TRIFLUOROMETHYL)-1-CHLOROBENZENE;3,5-Bis(trifluoromethyl)chlorobenzene 97%;3,5-Bis(trifluoromethyl)chlorobenzene97%
• CAS NO: 328-72-3
• Molecular Formula: C₈H₃ClF₆
• Molecular Weight: 248.55
• Product Categories: Miscellaneous
• Mol File: 328-72-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: -25 °C
• Boiling Point: 133.78°C (rough estimate)
• Flash Point: 42.7 °C
• Appearance: /
• Density: 1.475 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE(328-72-3)
• EPA Substance Registry System: 3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE(328-72-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 328-72-3(Hazardous Substances Data)

Usage

General Description

3,5-Bis(trifluoromethyl)chlorobenzene is a chemical compound consisting of a benzene ring with two trifluoromethyl groups and a chlorine atom attached at the 3 and 5 positions, respectively. It is a colorless liquid that is commonly used in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. The trifluoromethyl groups impart a high level of chemical stability and hydrophobicity to the compound, making it useful in the development of new materials and specialty chemicals. It is also used as a solvent and reagent in various chemical reactions due to its unique properties. However, it is important to handle this compound with care, as it can be harmful if ingested or inhaled and may cause irritation to the skin and eyes.

Upstream product

• 402-31-3 1,3-bis(trifluoromethyl)benzene 
• 121-91-5 isophthalic acid 
• 7647-18-9 antimonypentachloride 
• 7782-50-5 chlorine 
• 881-99-2 1,3-bis-trichloromethyl-benzene 

Downstream Products

• 1579-63-1 (3,5-bis-trifluoromethyl-phenyl)-dichloro-methyl-silane 
• 1027717-63-0 3,5-bis(trifluoromethyl)cinnamonitrile 
• 705250-77-7 3-[3,5-bis(trifluoromethyl)phenyl]-2(Z)-propenoic acid methyl ester 
• 166172-69-6 bis(3,5-bis(trifluoromethyl)phenyl)phosphine 
• 15979-14-3 bis[3,5-bis(trifluoromethyl) phenyl]phosphine oxide 
• 27126-93-8 3,5-bis(trifluoromethyl)benzonitrile 
• 368-67-2 3,5-bis-trifluoromethyl-phenetole 
• 349-60-0 1-methoxy-3,5-bis(trifluoromethyl)benzene 
• 69807-91-6 2-(3,5-bis-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 289686-70-0 α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid 
• 85068-32-2 3,5-bis(trifluoromethyl)phenylacetonitrile 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF ORGANIC HALIDES

The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.

Process for preparing chlorinated compounds

A process for the preparation of monochlorinated and dichlorinated bis-(perhalomethyl)-benzenes of the formula (I) by reacting bis-(perhalomethyl)-benzenes of the formula (II) with elementary chlorine in chlorosulfonic acid as the reaction medium, at a te