289686-70-0

Basic information

• Product Name: 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid
• Synonyms: 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid;α,α-DiMethyl-3,5-bis(trifluoroMethyl)benzeneaceticAcid;Netupitant SM1
• CAS NO: 289686-70-0
• Molecular Formula: C₁₂H₁₀F₆O₂
• Molecular Weight: 300.1970192
• EINECS: -0
• Mol File: 289686-70-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 105.5-107℃
• Boiling Point: 232.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.378±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.06±0.14(Predicted)
• CAS DataBase Reference: 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid(289686-70-0)
• EPA Substance Registry System: 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid(289686-70-0)

Safety Data

• Hazardous Substances Data: 289686-70-0(Hazardous Substances Data)

Usage

Uses

2-?(3,?5-?Bis(trifluoromethyl)?phenyl)?-?2-?methylpropanoic Acid is a reagent used in the synthesis of NK1/NK3 receptor antagonists used in the treatment of depression.

InChI:InChI=1S/C12H10F6O2/c1-10(2,9(19)20)6-3-7(11(13,14)15)5-8(4-6)12(16,17)18/h3-5H,1-2H3,(H,19,20)

Synthetic route

methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate (334477-48-4) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
Stage #1: methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate With lithium hydroxide; water In tetrahydrofuran; methanol at 20℃; for 72h; Stage #2: With hydrogenchloride In water	100%
With lithium hydroxide; water In tetrahydrofuran; methanol at 20℃; for 72h;	100%
With water; sodium hydroxide In methanol at 100℃; for 7h; Time; Temperature; Inert atmosphere;	90%

carbon monoxide (201230-82-2) + α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol (67570-38-1) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane; water at 20℃; under 22501.8 Torr; for 2h;	97%

3,5-bistrifluoromethylphenyl acetic acid (85068-33-3) + methyl iodide (74-88-4) → 2-methyl-2-(4-methyl-3,5-bis-trifluoromethyl-phenyl)-propionic acid + (RS)-α-Methyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-73-3) + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
Stage #1: 3,5-bistrifluoromethylphenyl acetic acid With n-butyllithium Stage #2: methyl iodide	A n/a B n/a C 91%

2-(3,5-bis-trifluoromethylphenyl)-2-methyl propionitrile → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
With sulfuric acid In water for 4h; Time; Reflux;	87%
With potassium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene; ethylene glycol at 135℃; for 12h; Autoclave; Large scale;	80%
Stage #1: 2-(3,5-bis-trifluoromethylphenyl)-2-methyl propionitrile With sodium hydroxide at 145℃; for 12h; Sealed tube; Large scale; Stage #2: With hydrogenchloride In water at 20℃; pH=1; Large scale;	2.43 kg

2-bromo-2-methylpropionic acid (2052-01-9) + 3,5-bis-trifluromethylphenylboronic acid (73852-19-4) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 60℃; for 3h; Reagent/catalyst; Inert atmosphere;	85%

3,5-bistrifluoromethylphenyl acetic acid (85068-33-3) + methyl iodide (74-88-4) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -50 - 20℃; for 5h; Inert atmosphere; Large scale;	77%

2-(3,5-bistrifluoromethylphenyl)propanenitrile + ethylene glycol (107-21-1) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
With potassium hydroxide at 135℃; for 20h; Reagent/catalyst; Temperature; Reflux;	73%

carbon monoxide (201230-82-2) + α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol (67570-38-1) → C22H16F12 + 4-methyl-2,4-di[3,5-bis(trifluoromethyl)phenyl]pent-1-ene + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
With trifluorormethanesulfonic acid at 0℃;	A n/a B n/a C 56%

3,6-bis(trifluoromethyl)bromobenzene (328-70-1) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: magnesium / diethyl ether / 1 h / 30 °C 1.2: diethyl ether / 0.75 h / 16 - 22 °C 2.1: 97 percent / CF3SO3H / CH2Cl2; H2O / 2 h / 20 °C / 22501.8 Torr View Scheme
Multi-step reaction with 3 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 1.2: 10 h / 90 °C 2.1: sodium hydroxide / methanol / 5 h / Reflux 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / -5 °C 3.2: 10 h / 50 °C View Scheme
Multi-step reaction with 2 steps 1: bis(η3-allyl-μ-chloropalladium(II)); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; 1,3,5-trimethyl-benzene / 20 h / 140 °C / Schlenk technique; Inert atmosphere; Reflux 2: potassium hydroxide / 20 h / 135 °C / Reflux View Scheme

3,5-(bistrifluoromethyl)chlorobenzene (328-72-3) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions

Yield

Multi-step reaction with 3 steps 1.1: bis(η3-allyl-μ-chloropalladium(II)); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,3,5-trimethyl-benzene / 20.25 h / 0 - 145 °C / Inert atmosphere; Large scale 2.1: sodium hydride / mineral oil; 1,4-dioxane / 10.25 h / 15 - 45 °C / Inert atmosphere; Large scale 3.1: sodium hydroxide / 12 h / 145 °C / Sealed tube; Large scale 3.2: 20 °C / pH 1 / Large scale View Scheme

dimethyl sulfate (77-78-1) + 3,5-bistrifluoromethylphenyl acetic acid (85068-33-3) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
Stage #1: 3,5-bistrifluoromethylphenyl acetic acid With sodium hydride In N,N-dimethyl-formamide at -5℃; for 1h; Stage #2: dimethyl sulfate In N,N-dimethyl-formamide at 50℃; for 10h;	325.1 g

2-(3,5-bistrifluoromethylphenyl)propanenitrile + glycerol (56-81-5) → α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0)

Conditions	Yield
With barium(II) hydroxide Reagent/catalyst; Concentration;

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride (289686-69-7)

Conditions	Yield
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide; toluene for 4.5h;	100%
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 17h;
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 24h;

oxalyl dichloride (79-37-8) + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride (289686-69-7)

Conditions	Yield
In dichloromethane; N,N-dimethyl-formamide for 4.5h;	100%
In dichloromethane; N,N-dimethyl-formamide; toluene

4-(3,5-dichlorophenoxy)-2-(piperazin-1-yl)pyrimidine + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis(trifluoromethyl)phenyl)-1-(4-(4-(3,5-dichlorophenoxy)pyrimidin-2-yl)piperazin-1-yl)-2-methylpropan-1-one

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 10h;	83%

C18H21ClN2O2 + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide (401891-55-2)

Conditions	Yield
Stage #1: C18H21ClN2O2 With trifluoroacetic acid In dichloromethane at 20℃; for 2h; Stage #2: α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In N,N-dimethyl-formamide at 100℃; for 4h;	75%

2-Amino-5-chlorobenzophenone (719-59-5) + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide (289686-54-0)

Conditions	Yield
Stage #1: 5-chloro-2-aminobenzophenone; α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid In 1,2-dichloro-ethane at 80℃; for 1h; Stage #2: With dicyclohexyl-carbodiimide In 1,2-dichloro-ethane at 80℃;	58%

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine hydrochloride (374822-30-7)

Conditions	Yield
Stage #1: α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With diphenyl phosphoryl azide; triethylamine In toluene at 90℃; for 18h; Stage #2: With hydrogenchloride; water for 18h; Heating / reflux; Stage #3: With hydrogenchloride In diethyl ether	20%

4-amino-4-phenylcyclohexan-1-one (95261-39-5) + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide (374791-63-6)

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 20℃;

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine (488098-44-8)

Conditions	Yield
Stage #1: α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With diphenyl phosphoryl azide; triethylamine In toluene at 90℃; Stage #2: With hydrogenchloride In diethyl ether at 20℃;

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → C12H11F6NO

Conditions	Yield
With ammonium chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methyl-morpholine

C17H25N3O3 + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → C29H31F6N3O3

Conditions	Yield
Stage #1: C17H25N3O3; α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In toluene at 110℃; Stage #2: In toluene at 110℃; Further stages.;

C17H24FN3O3 + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → C29H30F7N3O3

Conditions	Yield
Stage #1: C17H24FN3O3; α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide Stage #2: In toluene at 110℃; Further stages.;

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide (290296-68-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C 2: 17.3 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → netupitant (290297-26-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C 2: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4.5 h 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C View Scheme
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; dichloromethane / 4.5 h 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme
Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide; toluene / 4.5 h 2: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 4-oxo-1-phenyl-cyclohexanecarboxylic acid [1-(3,5-bis-trifluoromethyl-phenyl)-1-methyl-ethyl]-amide

Conditions	Yield
Multi-step reaction with 2 steps 1.1: (PhO)2PON3; Et3N / toluene / 90 °C 1.2: HCl / diethyl ether / 20 °C 2.1: Et3N; EDC; HOBt / dimethylformamide / 20 °C View Scheme

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis-trifluoromethyl-phenyl)-N-{4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexyl}-isobutyramide

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N; EDC; HOBt / dimethylformamide / 20 °C View Scheme

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis-trifluoromethyl-phenyl)-N-{4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexyl}-isobutyramide

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N; EDC; HOBt / dimethylformamide / 20 °C View Scheme

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexanecarboxylic acid [1-(3,5-bis-trifluoromethyl-phenyl)-1-methyl-ethyl]-amide

Conditions	Yield
Multi-step reaction with 3 steps 1.1: (PhO)2PON3; Et3N / toluene / 90 °C 1.2: HCl / diethyl ether / 20 °C 2.1: Et3N; EDC; HOBt / dimethylformamide / 20 °C View Scheme

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexanecarboxylic acid [1-(3,5-bis-trifluoromethyl-phenyl)-1-methyl-ethyl]-amide

Conditions	Yield
Multi-step reaction with 3 steps 1.1: (PhO)2PON3; Et3N / toluene / 90 °C 1.2: HCl / diethyl ether / 20 °C 2.1: Et3N; EDC; HOBt / dimethylformamide / 20 °C View Scheme

5-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-amine (889650-17-3) + α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-N-[5-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-yl]propanamide

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid (289686-70-0) → 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide (401891-55-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4.5 h 2: dmap / toluene / 23 h / 120 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C 2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / 20 °C / Inert atmosphere; Cooling with ice 2.2: 1 h / 20 °C / Inert atmosphere; Cooling with ice View Scheme
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; dichloromethane / 4.5 h 2: dmap / toluene / 23 h / 120 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide; toluene / 4.5 h 2: dmap / toluene / 23 h / 120 °C / Inert atmosphere View Scheme

Upstream product

• 289686-55-1 2,2-DIMETHYL-N-[4-(4-METHYLPIPERAZINO)PHENYL]PROPANAMIDE 
• 28968-64-1 Boc-N'-Nitro-L-homoarginine 
• 289681-47-6 2-Hydroxy-5-iodo-3-methylpyridine 
• 28968-09-4 (1S)-6-chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid 
• 28968-07-2 CLIDANAC 
• 28968-05-0 5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid 
• 289-67-8 Pyrylium 
• 289677-13-0 4-METHYL VALERYL PIPERIDINE THIOAMIDE 
• 289677-12-9 3',5'-DIFLUOROBENZENE ACETYL PIPERIDINE THIOAMIDE 
• 289677-11-8 (R)-4-BENZYL-3-(3-CYCLOPROPYL-PROPIONYL)-OXAZOLIDIN-2-ONE 
• 289677-10-7 (R)-4-BENZYL-3-(3-CYCLOPENTYL-PROPIONYL)-OXAZOLIDIN-2-ONE 
• 289677-08-3 3-CYCLOPENTYLPROPIONYL PIPERIDINE THIOAMIDE 
• 289677-07-2 1,8-Naphthyridine-2-carboxamide(9CI) 
• 289677-06-1 L-N-(4'-N-CBZ-PIPERIDINO)PROLINE 

Downstream Products

• 289686-74-4 2-CHLORO-N-METHOXY-N-METHYLBENZAMIDE 
• 289686-80-2 2-AMINO-4-CHLORO-5-METHYL-BENZONITRILE 
• 289686-83-5 7-chloro-2-(chloroMethyl)-6-Methylquinazolin-4(3H)-one 
• 289686-85-7 (7-chloro-3,6-diMethyl-4-oxo-3,4-dihydroquinazolin-2-yl)Methyl acetate 
• 289686-86-8 (6-(broMoMethyl)-7-chloro-3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl)Methyl acetate 
• 289686-87-9 tert-butyl 4-(((2-(acetoxyMethyl)-7-chloro-3-Methyl-4-oxo-3,4-dihydroquinazolin-6-yl)Methyl)(prop-2-ynyl)aMino)benzoate 
• 289687-20-3 2-BROMO-3-CHLORO-4-METHYLBENZENAMINE 
• 2896-87-9 FERROUSGLUTAMATE 
• 289688-87-5 3-Pyridinol,2-methoxy-6-methyl-(9CI) 
• 289-68-9 Phosphorine 
• 2896-91-5 [7S,(+)]-7-Ethyl-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9β-carboxylic acid methyl ester 
• 28969-37-1 2,5-diphenyl-6H-1,3,4-oxadiazin-6-one 4-oxide 
• 28969-57-5 5,6-dichloro-2-methylpyrimidin-4-amine 
• 28969-60-0 4-Amino-2,5,6-trichloropyrimidine 

Recommend Products

• 201230-82-2  carbon monoxide 
• 67570-38-1  α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol 
• 374822-30-7  α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine hydrochloride 
• 889650-17-3  5-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-amine 
• 289686-69-7  2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride 
• 79-37-8  oxalyl dichloride 
• 216059-91-5  4-(2-methylpyridin-4-yl)phenylamine 
• 85068-33-3  3,5-bistrifluoromethylphenyl acetic acid 
• 74-88-4  methyl iodide