335349-66-1

Basic information

• Product Name: 4-Iodo-5-Methoxy-2-nitro-phenylaMine
• Synonyms: 4-Iodo-5-Methoxy-2-nitro-phenylaMine
• CAS NO: 335349-66-1
• Molecular Formula: C₇H₇IN₂O₃
• Molecular Weight: 294.04655
• EINECS: -0
• Mol File: 335349-66-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Iodo-5-Methoxy-2-nitro-phenylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Iodo-5-Methoxy-2-nitro-phenylaMine(335349-66-1)
• EPA Substance Registry System: 4-Iodo-5-Methoxy-2-nitro-phenylaMine(335349-66-1)

Safety Data

• Hazardous Substances Data: 335349-66-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 335349-57-0 2-nitro-4-iodo-5-chloroaniline 
• 1635-61-6 5-chloro-2-nitroaniline 

Downstream Products

• 335349-65-0 1-(tert-butoxycarbonylamino)-4-iodo-5-methoxy-2-nitrobenzene 
• 1453393-64-0 8-(4'''-bromophenyl)-4-[3’-(1''H-imidazol-1''yl)phenyl]-7-methoxy-2,3-dihydro-1H-1,5-benzodiazepin-2-one 
• 1453393-70-8 4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-(4'''-iodophenyl)-7-methoxy-2,3-dihydro-1H-1,5-benzodiazepin-2-one 
• 1453393-97-9 4-(4''''-bromophenyl)-1-(tert-butoxycarbonylamino)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3’-oxopropanamido}-5-methoxybenzene 
• 1453394-04-1 4-[3’-(1''H-imidazol-1''-yl)phenyl]-7-methoxy-8-(4'''-(trimethylstannyl)phenyl)-2,3-dihydro-1H-1,5-benzodiazepin-2-one 
• 55215-55-9 1,4-diiodo-2-methoxy-5-nitrobenzene 

Relevant articles and documents

Method for synthesizing 1,4-diiodo-2-methoxy-5-nitrobenzene

The invention relates to the field of organic synthesis and discloses a method for synthesizing 1,4-diiodo-2-methoxy-5-nitrobenzene. The method includes the steps that firstly, 5-chloro-2-nitroaniline reacts with N-iodosuccinimide to generate 2-chloro-4-c

Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5- benzodiazepin-2-ones; Potential imaging agents of the metabotropic glutamate 2 receptor

A focused library of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones containing sites for 11C-, 18F- and 123I- labelling have been prepared and evaluated against membrane expressing human recombinant metabotropic glutamate 2 receptor (mGluR2). The compounds were found to be non-competitive antagonists with nanomolar affinity. HPLC evaluation of the physiochemical properties of these compounds identified two candidates for PET and SPECT imaging of mGluR2.

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1

A series of 1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Attachment of an 8-(2-aryl)-ethynyl-moiety produced compounds inhibiting the binding of [3H]-LY354740 to rat mGluR2 with low n

Glutamate receptor antagonists

The present invention relates to compounds of with a base structure of formula 1 The compounds of formula I are shown to have activity as metabotropic glutamate receptor antagonists.