3394-32-9

Basic information

• Product Name: 2-phenyl-1,3-oxazolidine
• Synonyms: 2-Phenyl-1,3-oxazolidine; Oxazolidine, 2-phenyl-
• CAS NO: 3394-32-9
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.1897
• Mol File: 3394-32-9.mol

Chemical Properties

• Boiling Point: 254.1°C at 760 mmHg
• Flash Point: 95.3°C
• Density: 1.065g/cm³
• Vapor Pressure: 0.0176mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 2-phenyl-1,3-oxazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1,3-oxazolidine(3394-32-9)
• EPA Substance Registry System: 2-phenyl-1,3-oxazolidine(3394-32-9)

Safety Data

• Hazardous Substances Data: 3394-32-9(Hazardous Substances Data)

Upstream product

• 151-56-4 ethyleneimine 
• 100-52-7 benzaldehyde 
• 770-37-6 2-(N-benzylidenamino)ethanol 
• 104-63-2 N-Benzylethanolamine 
• 60-29-7 diethyl ether 
• 141-43-5 ethanolamine 
• 100-44-7 benzyl chloride 
• 66021-75-8 ((2-azidoethoxy)methyl)benzene 

Downstream Products

• 56614-75-6 5,5-dimethyl-2(S)-phenylthiazolidine-4(S)-carboxylic acid 
• 3394-31-8 3-acetyl-2-phenyl-oxazolidine 
• 5772-16-7 2,2'-diphenyl-3,3'-malonyl-bis-oxazolidine 
• 141921-96-2 2,2-Dimethyl-6-(2-phenyl-oxazolidine-3-carbonyl)-2,3-dihydro-pyran-4-one 
• 63524-32-3 3-(2-hydroxy-ethyl)-2-phenyl-thiazolidin-4-one 
• 7127-19-7 2-phenyl-1,3-oxazoline 
• 141921-97-3 C₁₇H₁₉NO₄ 
• 124948-51-2 (E)-2-(benzylideneamino)ethanol 

Relevant articles and documents

A convenient synthesis of novel N-dichloroacetyl-1,3-oxazolidine

(Chemical Equation Presented) A short and efficient route of synthesis and structural characterization of a series of novel N-dichloroacetyl-1,3- oxazolidine derivatives has been developed. These new compounds characterized of the disubstitution at positi

A NOVEL AND SELECTIVE PROCEDURE FOR GENERATING IMINIUM CATION BY PHOTOSENSITIZED (SET) OXIDATIVE REACTION

A novel method of generating iminium cation by photosensitized single electron transfer process and its intramolecular cyclization by Oxigen and Carbon nucleophiles is reported.

NOVEL ANNULATION CATALYSTS VIA DIRECT C-H BOND AMINATION

Disclosed are compounds, methods, reagents, systems, and kits for the preparation and utilization of monomeric or polymeric metal-based compounds. These metal-based compounds are organometallic catalysts composed of substituted dipyrrin ligands bound to transition metals. C—H bond functionalization catalysis can be performed with the disclosed organometallic catalysts to yield C—N bonds to generate substituted bicyclic, spiro, and fused nitrogen-containing heterocycles, all common motifs in various pharmaceutical and bioactive molecules.

Fragment splicing-based design, synthesis and safener activity of novel substituted phenyl oxazole derivatives

Fragment splicing is a primary strategy in the design and optimization of leading compound toward new skeleton with target bioactivity. Herein a series of novel substituted phenyl oxazole derivatives were designed via fragment analysis and coupling strategy that led to highly potent and bio-selective herbicide safener. The biological tests showed that most of the compounds could enhance the maize growth index, glutathione content and anti-reverse enzyme glutathione S-transferase activity in vivo. The molecular docking model exhibited that the novel compound could compete with chlorsulfuron binding to the herbicide target enzyme, which consequently attained the herbicide detoxification. Especially compound I-f displayed the best activities than commercial safener isoxadifen-ethyl and other compounds. The present work demonstrates that the synthesized compounds could be developed as potential candidates for the discovery of novel herbicide safeners in the future.

METHOD FOR PRODUCING ACETAL COMPOUND BY USING 4-METHYLTETRAHYDROPYRAN AS SOLVENT

PROBLEM TO BE SOLVED: To provide a method for producing an acetal compound which is higher in safety and can be applied to a highly polar reaction raw material or the like. SOLUTION: There is provided a method for producing an acetal compound by reacting an alcohol compound, a thiol compound or an amine compound with a carbonyl compound in 4-methyltetrahydropyran. According to the production method of an acetal compound of the present invention, an acetal compound higher in safety can be produced under a mild reaction condition by using 4-methyltetrahydropyran having low toxicity and the method can be widely applied to a highly polar raw material. COPYRIGHT: (C)2015,JPOandINPIT

Variable C2-symmetric analogues of N-hydroxyphthalimide as enantioselective catalysts for aerobic oxidation: Kinetic resolution of oxazolidines

(Chemical Equation Presented) Fast and selective: The aerobic oxidative ring opening of oxazolidine 1 in the presence of a catalytic amount of the chiral N-hydroxyphthalimide analogue 2 was accompanied by efficient kinetic resolution of the oxazolidine. T

Efficient oxidative conversion of aldehydes to 2-substituted oxazolines and oxazines using (diacetoxyiodo)benzene

An efficient synthesis of 2-substituted oxazolines from aldehydes and 2-amino alcohol using (diacetoxyiodo)benzene as an oxidant, is reported. (Diacetoxyiodo)benzene acts as a mild dehydrogenating agent to convert the initially formed oxazolidine from ald

Stereoselective synthesis of 1,4,2-oxazaphosphorines as precursors of chiral α-aminophosphonic acids by intramolecular heterocyclization of β-aldiminoalkylphosphites

The intramolecular version of nucleophilic addison of phosphites to imines was carried out for the first time taking as an example β-aldimino-alkylphosphites, formed from chlorophosphites and β-aldiminoalcohols [N-(benzylidene)-2-aminoethanol and R-(+)-N-(benzylidene)-2-aminobutanol-1]. In these reactions, stereoisomeric 1,4,2-oxazaphospho-rines were obtained in good yields. R-(+)-N-(benzylidene)-2-aminobutanol-1 being used as a precursor, nucleophilic attack by P(III) atone on electrophilic C atom of the C=N group proceeds stereospecifically with participation of only re-face of the two possible diastereotopic faces of the imine double bond to give the epimeric at phosphorus (3R, 5R)-2-(β-chloroethyl)-2-oxo-3-phenyl-5-ethyl-1,4,2-oxazaphosphorines as precursors of nonracemic α-aminophosphonic acids.

Regioselective generation of iminium cation by PET processes: Its in situ trapping by intramolecular nucleophiles and synthesis of some biologically active heterocycles

Efficient, mild and direct route for regiospecific iminium cation is developed by sequential two electron oxidation of several N-alkylated tertiary amines by photoinduced electron transfer processes. The regiospecificity of iminium cation arises from the deprotonation step of amine radical cation to generate α-amino radical which depends on the stereoelectronic factor subject to kinetic acidity of amine radical cation. Iminium cation is efficiently trapped in situ by internal nucleophiles to give cyclic compounds 14-18 and 22a-c. Stereoselective synthesis of cis α,α'-dialkylated piperidines and pyrrolidines 30a-c is achieved by nucleophilic opening of tetrahydro-1,3-oxazines 22a-c.