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H-HYP-OET HCL is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 33996-30-4 Structure
  • Basic information

    1. Product Name: H-HYP-OET HCL
    2. Synonyms: Hydroxyproline ethyl ester hydrochloride;(2S,4R)-Ethyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride;(2S,3R)-Ethyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride;L-4-trans-Hydroxyproline ethyl ester hydrochloride≥ 99% (HPLC);4-trans-Hydroxy-L-proline ethyl ester hydrochloride;L-HYDROXYPROLINE ETHYL ESTER HYDROCHLORIDE;L-4-HYDROXY-L-PROLINE ETHYL ESTER HYDROCHLORIDE;L-4-HYDROXYPROLINE ETHYL ESTER HYDROCHLORIDE
    3. CAS NO:33996-30-4
    4. Molecular Formula: C7H13NO3*ClH
    5. Molecular Weight: 195.64
    6. EINECS: 251-779-0
    7. Product Categories: N/A
    8. Mol File: 33996-30-4.mol
  • Chemical Properties

    1. Melting Point: 150-153℃
    2. Boiling Point: 297.2 °C at 760 mmHg
    3. Flash Point: 133.5 °C
    4. Appearance: White/Powder
    5. Density: N/A
    6. Vapor Pressure: 0.00014mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Store at 0-5°C
    9. Solubility: N/A
    10. CAS DataBase Reference: H-HYP-OET HCL(CAS DataBase Reference)
    11. NIST Chemistry Reference: H-HYP-OET HCL(33996-30-4)
    12. EPA Substance Registry System: H-HYP-OET HCL(33996-30-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 33996-30-4(Hazardous Substances Data)

33996-30-4 Usage

Chemical Properties

White powder

Uses

H-Hyp-OEt HCl

Check Digit Verification of cas no

The CAS Registry Mumber 33996-30-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,9,9 and 6 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 33996-30:
(7*3)+(6*3)+(5*9)+(4*9)+(3*6)+(2*3)+(1*0)=144
144 % 10 = 4
So 33996-30-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H13NO3.ClH/c1-2-11-7(10)6-3-5(9)4-8-6;/h5-6,8-9H,2-4H2,1H3;1H/t5?,6-;/m0./s1

33996-30-4 Well-known Company Product Price

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  • Alfa Aesar

  • (H65633)  4-trans-Hydroxy-L-proline ethyl ester hydrochloride, 97%   

  • 33996-30-4

  • 5g

  • 435.0CNY

  • Detail
  • Alfa Aesar

  • (H65633)  4-trans-Hydroxy-L-proline ethyl ester hydrochloride, 97%   

  • 33996-30-4

  • 25g

  • 1826.0CNY

  • Detail
  • Alfa Aesar

  • (H65633)  4-trans-Hydroxy-L-proline ethyl ester hydrochloride, 97%   

  • 33996-30-4

  • 100g

  • 6518.0CNY

  • Detail

33996-30-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate,hydrochloride

1.2 Other means of identification

Product number -
Other names (2S,4R)-2-ethoxycarbonyl-4-hydroxypyrrolidine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33996-30-4 SDS

33996-30-4Relevant articles and documents

Amino 6-membered ring derivative and pharmaceutical applications thereof including the use for manufacturing dipeptidyl peptidase-4(IDPP-IV) inhibitor

-

Page/Page column 38, (2017/07/31)

The present invention relates to an amino 6-membered ring derivative and pharmaceutical applications thereof, which specifically relates to the amino 6-membered ring derivative represented by the general formula (I) or stereoisomers thereof, pharmaceutically acceptable salts thereof, a prodrug, a pharmaceutical composition comprising the derivative, and the pharmaceutical use for manufacturing dipeptidyl peptidase-4(IDPP-IV) inhibitor, wherein the definition of each substituent in the general formula (I) is the same as described in the specification.

Asymmetric reduction of ketones catalyzed by α,α-diphenyl-(L)-prolinol modified with imidazolium ionic liquid and BH3·SMe2 as a recoverable catalyst

Chauhan, ManMohan Singh,Singh, Surendra

, p. 184 - 189 (2015/02/19)

The synthesis of α,α-diphenyl-4-trans-hydroxy-(L)-prolinol modified with imidazolium based ionic liquids was carried out with trans-α,α-diphenyl-4-hydroxy-(L)-prolinol, 5-bromovaleric acid or 1,5-dibromopentane and imidazole. α,α-Diphenyl-4-hydroxy-(L)-prolinol modified with imidazolium ionic liquid was treated with BH3·SMe2 which generate 1,3,2-oxazaborolidine, that acts as a catalyst for asymmetric reduction of prochiral ketones. α,α-Diphenyl-4-hydroxy-(L)-prolinol modified with imidazolium ionic liquids (PF6 anion) with BH3?SMe2 found to be an efficient catalyst (10 mol%) for the reduction of the acetophenone, gave 99% yield and 87-84% ee. The catalytic method has wide applicability for a variety of substrates. 1,3,2-oxazaborolidine containing ether linkage ionic liquid was recovered and reused up to 4 cycles with 99-91% yields and 87-81% ee's.

A formal synthesis of (+)-lactacystin from 4-hydroxyproline

Mycock, David K.,Glossop, Paul A.,Lewis, William,Hayes, Christopher J.

supporting information, p. 55 - 57 (2013/02/21)

A formal synthesis of (+)-lactacystin has been completed from trans-4-hydroxyproline, using a diastereoselective enolate acylation reaction as a key step. Diastereoselectivity was seen to vary as a function of the steric bulk of the C4-O-protecting group, and contrary to expectations, the best diastereoselectivities were obtained when the small methyl carbonate protecting group was used. The formal synthesis was then completed by intercepting Shibasaki's route via methyl carbonate deprotection, dehydration, 3-pyrroline to 3-pyrrolinone oxidation, hydrogenation and N-CO2Me deprotection.

A heterogeneous layered bifunctional catalyst for the integration of aerobic oxidation and asymmetric C-C bond formation

Miyamura, Hiroyuki,Choo, Gerald C. Y.,Yasukawa, Tomohiro,Yoo, Woo-Jin,Kobayashi, Shu

supporting information, p. 9917 - 9919 (2013/10/22)

The design and synthesis of a heterogeneous bifunctional chiral catalyst for the sequential aerobic oxidation-asymmetric Michael reactions between primary allylic alcohols and dibenzyl malonate are described. Interestingly, we found that layering bimetallic nanoparticles over the organocatalyst, within the chiral composite material, is crucial for catalytic activity.

HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE

-

Page/Page column 159; 160, (2013/07/19)

The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.

HYDROGEN CHLORIDE SALT OF A SUBSTITUTED 5-OXAZOL-2-YL-QUINOLINE COMPOUND AND A PROCESS FOR THE PRODUCTION THEREOF

-

Page/Page column 4, (2011/01/12)

The present invention relates to the compound of the Formula I: and to methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to a particular crystalline form and processes of synthesis of the crystalline form. IM=105109

Design and stereoselective synthesis of four peptide nucleic acid monomers with cyclic structures in backbone

Watanabe, Akiko,Kiyota, Naotoshi,Yamasaki, Tetsuo,Tanda, Kazuhiro,Miyagoe, Tatsunori,Sakamoto, Masanori,Otsuka, Masami

experimental part, p. 1132 - 1139 (2011/11/05)

Four isomers of the monomer of peptide nucleic acid (PNA) were derived from (2S,4R)-4-hydroxyproline; they had different stereochemistries at the C 2 and C4 positions in the pyrrolidine ring. These different backbone conformations corresponding to four different stereochemistries were realized through a combination of inversions at the C2 and the C4 positions in pyrrolidine ring. The obtained backbone frameworks were reacted with N-benzoyl thymine to give the corresponding PNA monomers. Spectroscopic comparison of the resultant monomers confirmed their stereochemistries.

Heck reaction on morita-baylis-hillman adducts: Diastereoselective synthesis of pyrrolizidinones and pyrrolizidines

Delunafreire, Kristerson R.,Tormena, Cláudio F.,Coelho, Fernando

supporting information; experimental part, p. 2059 - 2063 (2011/10/09)

An efficient approach to the diastereoselective synthesis of benzylidene-, benzyl-pyrrolizidinones, and pyrrolizidines is described. The sequence is based on a highly stereoselective Heck reaction between a hydroxylated pyrrolizidinone, prepared from a Morita-Baylis-Hillman adduct, and a suitable aryl halide, using Nájeras oxime derived palladacycle as catalyst. Georg Thieme Verlag Stuttgart - New York.

A general approach for preparation of polymer-supported chiral organocatalysts via acrylic copolymerization

Kristensen, Tor E.,Vestli, Kristian,Jakobsen, Martin G.,Hansen, Finn K.,Hansen, Tore

supporting information; experimental part, p. 1620 - 1629 (2010/04/29)

(Figure Presented) Polymer-supported chiral organocatalysts, as well as most other forms of immobilized catalysts, are traditionally prepared by a postmodification approach where modified catalyst precursors are anchored onto prefabricated polymer beads. Herein, we report an alternative and more scalable approach where polymer-supported chiral enamine and iminium organocatalysts are prepared in a bottom-up fashion where methacrylic functional monomers are prepared in an entirely nonchromatographic manner and subsequently copolymerized with suitable comonomers to give cross-linked polymer beads. All syntheses have been conducted on multigram scale for all intermediates and finished polymer products, and the catalysts have proven successful in reactions taking place in solvents spanning a wide range of solvent polarity. While polymer-supported proline and prolineamides generally demonstrated excellent results and recycling robustness in asymmetric aldol reactions of ketones and benzaldehydes, the simplest type of Joargensen/Hayashi diarylprolinol TMS-ether showed excellent selectivity, but rather sluggish reactivity in the Enders-type asymmetric cascade. The polymer-supported version of the first-generation MacMillan imidazoHdinone had a pattern of reactivity very similar to that of the monomeric catalyst, but is too unstable to allow recycling.

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