3430-34-0

Basic information

• Product Name: 2,6-Dimethyl-3,5-dibromopyridine
• Synonyms: 2-Chloro-5-Methyl-pyriMidin-4-ylaMine;Pyridine, 3,5-dibroMo-2,6-diMethyl-
• CAS NO: 3430-34-0
• Molecular Formula: C₇H₇Br₂N
• Molecular Weight: 264.96
• Product Categories: Heterocycle-Pyridine series
• Mol File: 3430-34-0.mol

Chemical Properties

• Melting Point: 46-57 °C
• Boiling Point: 240.2 °C at 760 mmHg
• Flash Point: 99.1 °C
• Appearance: /
• Density: 1.795 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.96±0.20(Predicted)
• CAS DataBase Reference: 2,6-Dimethyl-3,5-dibromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dimethyl-3,5-dibromopyridine(3430-34-0)
• EPA Substance Registry System: 2,6-Dimethyl-3,5-dibromopyridine(3430-34-0)

Safety Data

• Hazardous Substances Data: 3430-34-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dimethyl-3,5-dibromopyridine serves as a key intermediate in the synthesis of various pharmaceuticals. Its ability to undergo multiple types of chemical reactions makes it instrumental in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,6-Dimethyl-3,5-dibromopyridine is utilized as a precursor in the production of pesticides and other agrochemicals. Its reactivity and structural features contribute to the creation of compounds that can effectively address pest and disease control in agriculture.
Used in Research and Development:
2,6-Dimethyl-3,5-dibromopyridine is also employed as a building block in the synthesis of new materials for research and development purposes. Its unique chemical properties facilitate the exploration of novel applications and the advancement of scientific knowledge in material science and related fields.

Upstream product

• 108-48-5 2,6-dimethylpyridine 
• 3430-33-9 2,6-dimethylpyridin-3-amine 

Downstream Products

• 65907-81-5 2,6-dimethyl-3,5-diphenylpyridine 
• 1463-03-2 2,6-dimethyl-3-phenylpyridine 

Relevant articles and documents

Synthesis method of 2, 6-dimethyl-3, 5-dibromopyridine

The invention relates to the field of organic chemistry, in particular to a synthesis method of 2, 6-dimethyl-3, 5-dibromopyridine. The method includes following steps: (1), adding 2, 6-dimethyl-3-aminopyridine and acetic anhydride into a four-neck flask, rising temperature to backflow, and allowing thin-layer chromatography tracking reaction; (2), when temperature of reaction liquid in the step (1) is lowered to below 23 DEG C, dropwise adding liquid bromine, allowing reaction at 40-55 DEG C for 2-3h after dropwise adding is completed, adding water until all solid is dissolved, dropwise adding a sodium hydroxide solution, continuing reaction for 20-40min when a lot of precipitate is generated, suction-filtering, drying, and recrystallizing to obtain 2, 6-dimethyl-3-amino-5 bromopyridine;(3), adding 2, 6-dimethyl-3-amino-5 bromopyridine into a hydrogen bromide solution, dropwise adding a saturated sodium nitrite solution at the presence of cuprous bromide in a catalysis amount, controlling temperature to -3-4 DEG C, and allowing reaction for 2-3h to obtain 2, 6-dimethyl-3, 5-dibromopyridine.The method has the advantages of being mild in reaction condition, high in yield, easy-to-get in raw material, low in cost and short in process route and having industrialization prospect.

Synthetic method of 2,6-dimethyl-3,5-dibromopyridine

The invention relates to the field of organic chemistry, in particular to a synthetic method of 2,6-dimethyl-3,5-dibromopyridine. The synthetic method comprises the following steps: (1) adding 2,6-dimethyl-3-aminopyridine and acetic anhydride into a four-necked flask, raising the temperature till backflow and performing thin layer chromatography tracking reaction; (2) after the temperature of reaction liquid in the step (1) is reduced to below 23 DEG C, dropwise adding liquid bromine, reacting for 2-3 hours at a temperature of 40-55 DEG C after the completion of dropwise adding, adding water till all solids are dissolved, then dropwise adding a sodium hydroxide solution, continuously reacting for 20-40 minutes after the generation of a large number of precipitates, performing suction filtration, drying and re-crystallizing to obtain 2,6-dimethyl-3-amino-5-bromopyridine; (3) adding the 2,6-dimethyl-3-amino-5-bromopyridine into a hydrogen bromide solution, dropwise adding a saturated sodium nitrite solution under the existence of a catalytic amount of cuprous bromide, controlling the temperature between 3 DEG C below zero and 4 DEG C and reacting for 2-3 hours to obtain the 2,6-dimethyl-3,5-dibromopyridine. The synthetic method provided by the invention is mild in reaction condition, high in yield, readily-available in raw material, lower in cost and short in process route and has an industrial prospect.