349662-62-0Relevant articles and documents
A practical synthesis of 5-functionalized thieno[2,3-d]pyrimidines
Wilding, Birgit,Faschauner, Stefan,Klempier, Norbert
supporting information, p. 4486 - 4489 (2015/06/30)
Abstract The synthesis of 5-hydroxymethyl-, 5-acetoxymethyl-, 5-formyl- and 5-cyanothieno[2,3-d]pyrimidines, the (methyl)-5-carboxylate, and the respective amide functionality was accomplished by building up the functionalized molecule starting from appropriately substituted thiophene precursors. A similar strategy starting from the pyrimidine precursor and subsequent direct functionalization (formylation and cyanation) of the thieno[2,3-d]pyrimidine parent compound in position 5 was found to be less feasible.
Anti-infective agents
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, (2008/06/13)
Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
Synthesis of novel 2-aminothiophene-3-carboxylates by variations of the Gewald reaction
Buchstaller,Siebert,Lyssy,Frank,Duran,Gottschlich,Noe
, p. 279 - 293 (2007/10/03)
The synthesis of the title compounds through variations of the Gewald reaction is presented. Knoevenagel condensation of methylketone derivatives with methyl cyanoacetate and subsequent treatment of the α,β-unsaturated nitriles with sulfur and amine resul
