40235-68-5

Basic information

• Product Name: 1-ACETOXY-3-CHLOROACETONE
• Synonyms: 1-ACETOXY-3-CHLORO-2-PROPANONE;1-ACETOXY-3-CHLOROACETONE;1-ACETOXY-3-ACETENYL CHLORIDE;1-(acetyloxy)-3-chloro-2-propanon;1-acetoxy-3-chloropropan-2-one;aceticacid,chloroacetylmethylester;chlorohydroxyacetoneacetate;Acetoxychloroacetone
• CAS NO: 40235-68-5
• Molecular Formula: C₅H₇ClO₃
• Molecular Weight: 150.56
• Mol File: 40235-68-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 200.9°Cat760mmHg
• Flash Point: 86.4°C
• Appearance: /
• Density: 1.28
• Vapor Pressure: 0.316mmHg at 25°C
• Refractive Index: 1.4510-1.4540
• CAS DataBase Reference: 1-ACETOXY-3-CHLOROACETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ACETOXY-3-CHLOROACETONE(40235-68-5)
• EPA Substance Registry System: 1-ACETOXY-3-CHLOROACETONE(40235-68-5)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-34-36-25
• Safety Statements: 23-26-36/37/39-45
• RIDADR: 2922
• RTECS: AF8600000
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 40235-68-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless or light yellow oily liquid

InChI:InChI=1/C5H7ClO3/c1-4(7)9-3-5(8)2-6/h2-3H2,1H3

Upstream product

• 127-08-2 potassium acetate 
• 534-07-6 1,3-Dichloroacetone 
• 5976-47-6 2-chloroallyl alcohol 
• 64-19-7 acetic acid 
• 24573-30-6 3-chloro-2-hydroxy-1-propyl acetate 
• 591-87-7 Allyl acetate 
• 13530-68-2 dichromic acid 
• 108-24-7 acetic anhydride 
• 127-09-3 sodium acetate 

Downstream Products

• 106939-35-9 2-(3-acetoxy-2-oxo-propyloxy)-3,4-difluoronitrobenzene 
• 64804-78-0 N-(2ξ-acetoxymethyl-2ξ-hydroxy-8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]oct-7t-yl)-2-phenyl-acetamide 
• 64804-77-9 N-(2-acetoxymethyl-8-oxo-(6rH)-4-thia-1-aza-bicyclo[4.2.0]oct-2-en-7t-yl)-2-phenyl-acetamide 
• 50917-92-5 5-acetoxymethyl-6H-[1,3]thiazine-4-carboxylic acid 4-methoxy-benzyl ester 
• 1620136-28-8 3-acetoxy-2-oxopropyl 2-(diethoxyphosphoryl)-2-phenylacetate 
• 1421922-72-6 [2-(2,5-dimethyl-4-nitrobenzyl)-1,3-thiazol-4-yl]methyl acetate 
• 1384439-00-2 1-acetoxy-3-(4-methylphenylsulfonyl)acetone 
• 1384438-99-6 1-acetoxy-3-(4-methylphenylthio)acetone 
• 1206612-19-2 4-[4-(4-acetoxymethyl-4-hydroxy-4,5-dihydro-thiazol-2-yl)-tetrahydro-pyran-4-yl]-benzoic acid methyl ester 
• 219539-89-6 (2-(4-chlorophenyl)thiazol-4-yl)methyl acetate 
• 1005788-25-9 (6-iodoimidazo[1,2-b]pyridazin-2-yl)methanol 

Relevant articles and documents

Clean preparation method of 4-hydroxymethylthiazole and its intermediate

The invention discloses a clean preparation method of 4-hydroxymethylthiazole and its intermediate. The clean preparation method includes, taking compound I as an example, the steps of in a solvent, subjecting compound IV and an alkali metal hypohalite to

Tropospheric chemical degradation of vinyl and allyl acetate initiated by Cl atoms under high and low NOx conditions

The products of the reactions of Cl atoms with vinyl acetate (VA) and allyl acetate (AA) have been investigated in a 1080 L chamber using in situ FTIR. The experiments were performed at 296 K and atmospheric pressure of synthetic air in the presence and in the absence of NOx. For the reaction of Cl with VA in the presence of NOx formic acetic anhydride, acetic acid and formyl chloride are the major reaction products. In the absence of NOx, the yields of these products are significantly reduced and formation of the carbon-chain-retaining compound CH3C(O)OC(O)CH2Cl is observed. For the reaction of Cl with AA in the presence of NOx acetoxyacetaldehyde and formaldehyde were observed as the main products. In contrast, without NOx, the observations support that the major reaction pathway is the formation of the carbon-chain-retaining compound CH3C(O)OCH2C(O)CH2Cl. The reaction mechanisms leading to the products are discussed. The formation of the high yields of formyl chloride and formaldehyde in the reactions of Cl with VA and AA, respectively, are at odds with currently accepted mechanistic pathways.

2-GUANIDINO-4-HYDROXYMETHYL-THIAZOLE AND DERIVATIVES THEREOF

A compound of the formula: STR1 wherein R is hydrogen, C. sub.1-C. sub.5 alkanoyl or substituted sulfonyl, which is useful as a synthetic intermediate to 2-guanidino-4-[2-(formamido)ethylthiomethyl] thiazole, histamine H 2 receptor antagonist.