35047-29-1

Basic information

• Product Name: alpha-2-pyridylpyridine-2-methanol
• Synonyms: alpha-2-pyridylpyridine-2-methanol;2,2'-(Hydroxymethylene)bispyridine;Bis(2-pyridyl)methanol;α-(2-Pyridinyl)-2-pyridinemethanol;2-PyridineMethanol, alpha-2-pyridinyl-;Di(pyridin-2-yl)Methanol
• CAS NO: 35047-29-1
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.2099
• EINECS: 252-338-5
• Mol File: 35047-29-1.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 342.1°Cat760mmHg
• Flash Point: 160.7°C
• Appearance: /
• Density: 1.212g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: alpha-2-pyridylpyridine-2-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-2-pyridylpyridine-2-methanol(35047-29-1)
• EPA Substance Registry System: alpha-2-pyridylpyridine-2-methanol(35047-29-1)

Safety Data

• Hazardous Substances Data: 35047-29-1(Hazardous Substances Data)

Usage

General Description

Alpha-2-pyridylpyridine-2-methanol is a chemical compound that is commonly used as a chelating agent and a preservative in pharmaceutical and cosmetic products. It is also known as DMPA or 2,2'-dipyridyl, and is effective at stabilizing and preserving various formulations. alpha-2-pyridylpyridine-2-methanol is also used as an anti-tumor agent and an inhibitor of various enzymes. It has potential applications in the field of medicine and science as a chelating agent for metal ions and as a treatment for certain medical conditions. However, it is important to handle this chemical with caution due to its potential toxicity if ingested or inhaled.

Upstream product

• 19437-26-4 2,2'-dipyridyl ketone 
• 3340-78-1 2-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 16940-66-2 sodium tetrahydroborate 
• 58088-50-9 bis(pyridin-2-yl)methylamine 
• 952-92-1 1-Benzyl-1,4-dihydronicotinamide 
• 1121-60-4 pyridine-2-carbaldehyde 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 1132-37-2 bis(2-pyridyl)methane 

Relevant articles and documents

Kinetics and Mechanism of the Nickel(II)- and Copper(II)- promoted Reduction of Di-2-pyridyl Ketone with Sodium Tetrahydroborate

The kinetics of reduction of di-2-pyridyl ketone with NaBH4 leading to the formation of di-2-pyridylmethanol (dpm) was studied in the presence of Ni(II) or Cu(II).The metal ion-promoted reduction involved two successive intermediates.Based on the visible spectra and kinetic data concerning the intermediates, it is proposed that the first intermediate is (nickel(I) or copper(I) complex of the anion of dpm and that the second intermediate is the corresponding complex of dpm.

Light-driven MPV-type reduction of aryl ketones/aldehydes to alcohols with isopropanol under mild conditions

Alcohols are versatile structural motifs of pharmaceuticals, agrochemicals and fine chemicals. With respect to green chemistry, the development of more sustainable and cost-efficient processes for converting ketones/aldehydes to alcohols is highly desired. Herein, a direct light-driven strategy for reducing ketones/aldehydes to alcohols using isopropanol as the reducing agent and solvent, in the presence of t-BuOLi, under an air atmosphere at room temperature is developed. This operationally simple light-promoted Meerwein-Ponndorf-Verley (MPV) type reduction can be used to produce various benzylic alcohol derivatives as well as applied to bioactive molecules and PEEK model compounds, demonstrating its application potential.

Ruthenium complexes with PYA pincer ligands for catalytic transfer hydrogenation of challenging substrates

Here we highlight the potential of a series of ruthenium complexes with tridentate N,N,N pincer-type ligands featuring two pyridylidene amide (PYA) moieties in the ligand skeleton. They were successfully applied in transfer hydrogenation of ketones and C=C double bonds. Rational ligand design was key for increasing the catalytic performance in the reduction of challenging substrates such as potentially chelating acetylpyridines. The specific reaction profiles indicate catalyst poisoning via imine coordination as well as N,O-bidentate coordination of the substrate or the product. Approaches to mitigate this inhibition are presented. Furthermore, these PYA pincer ruthenium complexes accomplish the selective reduction of the C=C over C=O bond of α,β-unsaturated ketones such as benzylideneacetone, while other α,β-unsaturated ketones such as trans-chalcone predominantly underwent oxidative C=C bond cleavage.