351-98-4

Basic information

• Product Name: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-
• CAS NO: 351-98-4
• Molecular Formula: C14H10F3N
• Molecular Weight: 249.235
• Mol File: 351-98-4.mol
• Article Data: 38

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-(351-98-4)
• EPA Substance Registry System: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-(351-98-4)

Safety Data

• Hazardous Substances Data: 351-98-4(Hazardous Substances Data)

Upstream product

• 5586-13-0 1-azido-4-(trifluoromethyl)benzene 
• 100-51-6 benzyl alcohol 
• 402-54-0 p-nitrobenzotrifluoride 
• 100-52-7 benzaldehyde 
• 23056-94-2 2-methyl-1-hexen-3-yne 
• 455-14-1 4-trifluoromethylphenylamine 
• 26456-05-3 10-methylacridinium perchlorate 
• 538-51-2 benzylidene phenylamine 

Downstream Products

• 1621980-91-3 C₃₀H₃₈F₃N 
• 1621981-02-9 C₂₈H₃₀F₃N 
• 405-81-2 N-benzyl-4-(trifluoromethyl)aniline 
• 143874-20-8 (3R,4S)-3,4-Diphenyl-1-(4-trifluoromethyl-phenyl)-azetidin-2-one 
• 1310569-12-0 2,2,2-trifluoro-N-(4-(trifluoromethyl)phenyl)ethanethioamide 
• 350-98-1 N-(4-(trifluoromethyl)phenyl)benzamide 
• 33768-43-3 N-(2-formylphenyl)benzamide 

Relevant articles and documents

Rhodium(III)-amine dual catalysis for the oxidative coupling of aldehydes by directed C-H activation: Synthesis of phthalides

A novel oxidative coupling of aldehydes to form C3-substituted phthalides facilitated by co-operative dual catalysis of a Rh(III) complex and an aryl amine is reported. The reaction involves a cascade ortho C-H activation-insertion-annulation sequence. This methodology is efficient and applicable for the homo- and heterocoupling of various functionalized aldehydes generating the corresponding phthalides in moderate to high yields.

Direct synthesis of imines from nitro compounds and biomass-derived carbonyl compounds over nitrogen-doped carbon material supported Ni nanoparticles

The selective synthesis of imines from biomass-derived chemicals over heterogeneous non-noble metal catalysts is of great importance for organic transformation. Herein, non-noble heterogeneous nitrogen-doped carbon supported Ni catalysts (abbreviated as Ni/CN-MgO-T, whereTrepresents the pyrolysis temperature) have been facilely prepared from the simple pyrolysis of Ni precursors and biomass, and Ni/CN-MgO-600 with the smallest size of Ni nanoparticles demonstrated the highest catalytic activity. The reductive coupling of nitroarenes and carbonyl compounds could be performed under mild conditions (80 °C, and 10 bar H2), affording structurally-diverse imines with high to excellent yields (84.2-98.1%). Thanks to the mild reaction conditions, the developed method showed good tolerance to other functional groups such as nitriles, halogen and vinyl groups.

[(PPh3)2NiCl2]-Catalyzed C-N bond formation reaction via borrowing hydrogen strategy: Access to diverse secondary amines and quinolines

Commercially available [(PPh3)2NiCl2] was found to be an efficient catalyst for the mono-N-alkylation of (hetero)- A romatic amines, employing alcohols to deliver diverse secondary amines, including the drug intermediates chloropyramine (5b) and mepyramine (5c), in excellent yields (up to 97%) via the borrowing hydrogen strategy. This method shows a superior activity (TON up to 10000) with a broad substrate scope at a low catalyst loading of 1 mol % and a short reaction time. Further, this strategy is also successful in accessing various quinoline derivatives following the acceptorless dehydrogenation pathway.