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3663-21-6

3663-21-6

Identification

Synonyms:Acetanilide,4'-butyl-2'-nitro- (6CI,7CI,8CI);acetamide, N-(4-butyl-2-nitrophenyl)-;n-(4-butyl-2-nitrophenyl)acetamide;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:N-(4-BUTYL-2-NITROPHENYL)ACETAMIDE 95.00%
  • Packaging:5MG
  • Price:$ 502.99
  • Delivery:In stock
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Relevant articles and documentsAll total 5 Articles be found

5-n-butyl-1H-benzotriazole synthesis process

-

, (2016/12/01)

The present invention discloses a 5-n-butyl-1H-benzotriazole synthesis process, which comprises: adding concentrated sulfuric acid to acetic anhydride in a dropwise manner, and adding 4-n-butyl aniline in a dropwise manner to prepare 4-n-butyl acetanilide; adding a mixed acid solution comprising 65% concentrated nitric acid and acetic anhydride to the 4-n-butyl acetanilide in a dropwise manner to synthesize 4-n-butyl-2-nitro acetanilide; synthesizing 4-n-butyl-2-nitroaniline by using the 4-n-butyl-2-nitro acetanilide, 95% ethanol and 40% sodium hydroxide as raw materials; under the effect of a catalyst, using the 4-n-butyl-2-nitroaniline and dehydrated alcohol and sequentially using nitrogen and hydrogen to convert under a closed condition to prepare 4-n-butyl-o-phenylenediamine; and adding the 4-n-butyl-o-phenylenediamine, water and sodium nitrite to an autoclave to synthesize the 5-n-butyl-1H-benzotriazole. According to the present invention, the process equipment is simple, and the product yield is high.

Photochemistry of (2-nitrophenyl)diazomethane studied by the matrix isolation technique. (Nitrophenyl)carbene to (carboxylphenyl)nitrene rearrangement by successive reduction of the nitro group with the carbenic center

Tomioka, Hideo,Ichikawa, Naoki,Komatsu, Kazunori

, p. 8045 - 8053 (2007/10/02)

Irradiation (λ > 350 nm) of (2-nitrophenyl)diazomethane (1) matrix-isolated in Ar at 10 K provided 2-nitrosobenzaldehyde (3) presumably as a result of intramolecular oxygen migration in (2-nitrophenyl)carbene (2). Upon further irradiation (λ > 350 nm), 3 was decomposed to give a mixture of 2,1-benzisoxazol-3(1H)-one (4) and carbonylcyclopentadiene imine (5) along with CO2. The oxazolone (4) underwent decarboxylation to give 5 upon irradiation with shorter wavelength light (λ > 300 nm) but not at longer wavelength (λ > 350 nm), suggesting 4 is not the direct precursor for 5 in the photolysis of 3. Irradiation (λ > 350 nm) of (4-n-butyl-2-nitrophenyl)diazomethane (1b) under similar conditions resulted in the formation of carbonyloximinocyclohexadienylidene (7) which then produced the oxazolone (4b) and the imine (5b) upon further irradiation, suggesting that a 1,4-biradical generated as a result of abstraction of H at the ortho position by the photoexcited nitroso group was involved in the reaction of 3 forming 4. (2-Carboxyphenyl)nitrene (9) generated by 1,4-OH shift in the 1,4-biradical was postulated as an intermediate leading to 5, and this was actually demonstrated by independent generation of 9 by the photolysis of 2-azidobenzoic acid (8).

Treatment of helminth infections with substituted phenyl-thiourea derivatives

-

, (2008/06/13)

Benzene derivatives of the formula:- STR1 wherein R is an aliphatic hydrocarbon group of 1 to 4 carbon atoms optionally substituted by halogen or alkoxy, R1 is hydrogen or methyl, R2 is hydrogen, halogen, alkyl, alkanoylamino optionally substituted by cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonylamino, alkanoyl, benzoyl or N-methylmethanesulphonylamino, and Y is primary amino or substituted amino, possess anthelmintic and anti-viral activity. New compounds within that formula possess fungicidal properties.

Process route upstream and downstream products

Process route

N-(4-butylphenyl)acetamide
3663-20-5

N-(4-butylphenyl)acetamide

N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

Conditions
Conditions Yield
With nitric acid; acetic acid; for 1h; Ambient temperature;
98.3%
With nitric acid; acetic anhydride; In acetic acid; at -15 ℃; for 6h;
70%
With nitric acid; acetic acid; at -5 - 5 ℃;
With sulfuric acid; nitric acid; acetic acid; at 0 - 20 ℃;
6.18 g
With nitric acid; acetic anhydride; acetic acid; at 4 - 40 ℃; for 2.5h;
4-Butylaniline
104-13-2

4-Butylaniline

N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 90 percent / cc. sulphuric acid / 1 h / 50 °C
2: 70 percent / fuming nitric acid, acetic anhydride / acetic acid / 6 h / -15 °C
With nitric acid; acetic anhydride; sulfuric acid; In acetic acid;
Multi-step reaction with 2 steps
2: glacial acetic acid; nitric acid / -5 - 5 °C
With nitric acid; acetic acid;
Multi-step reaction with 2 steps
2: glacial acetic acid; nitric acid / -5 - 5 °C
With nitric acid; acetic acid;
Multi-step reaction with 2 steps
1: sulfuric acid / 1.8 h / 58 °C
2: acetic anhydride; nitric acid; acetic acid / 2.5 h / 4 - 40 °C
With sulfuric acid; nitric acid; acetic anhydride; acetic acid;
1-butylbenzene
104-51-8

1-butylbenzene

N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: glacial acetic acid; fuming nitric acid / 10 °C
2: tin; hydrochloric acid
4: glacial acetic acid; nitric acid / -5 - 5 °C
With hydrogenchloride; tin; nitric acid; acetic acid;
Multi-step reaction with 4 steps
1: HNO3+H2SO4 / 5 - 12 °C
2: tin; hydrochloric acid
4: glacial acetic acid; nitric acid / -5 - 5 °C
With hydrogenchloride; tin; sulfuric acid; nitric acid; acetic acid;
1-butyl-4-nitro-benzene
20651-75-6

1-butyl-4-nitro-benzene

N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: tin; hydrochloric acid
3: glacial acetic acid; nitric acid / -5 - 5 °C
With hydrogenchloride; tin; nitric acid; acetic acid;
aniline
62-53-3

aniline

N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: zinc chloride / 230 - 240 °C
3: glacial acetic acid; nitric acid / -5 - 5 °C
With nitric acid; acetic acid; zinc(II) chloride;
Multi-step reaction with 4 steps
1: zinc chloride / 180 - 200 °C
2: cobalt chloride / >200
4: glacial acetic acid; nitric acid / -5 - 5 °C
With cobalt chloride; nitric acid; acetic acid; zinc(II) chloride;
N-(n-butyl)aniline
1126-78-9

N-(n-butyl)aniline

N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: cobalt chloride / >200
3: glacial acetic acid; nitric acid / -5 - 5 °C
With cobalt chloride; nitric acid; acetic acid;
N-(4-butylphenyl)acetamide
3663-20-5

N-(4-butylphenyl)acetamide

acetic acid
64-19-7,77671-22-8

acetic acid

N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

Conditions
Conditions Yield
at -5 - 5 ℃;
N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

Conditions
Conditions Yield
Aus d. Stammverb., HNO3;
/BRN= 803681/ (III), 1) Ac2O, AcOH, 2) HNO3, AcOH;
N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

m-(n-butyl)-aniline
5369-17-5

m-(n-butyl)-aniline

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: alcoholic KOH-solution / Hydrolysis
2: copper powder / Diazotization.Verkochen mit Alkohol
3: tin; hydrochloric acid
With hydrogenchloride; potassium hydroxide; tin; copper;
Multi-step reaction with 3 steps
1: alcoholic hydrochloric acid / Hydrolysis
2: Diazotization.Verkochen mit Alkohol
3: tin; hydrochloric acid
With hydrogenchloride; tin;
Multi-step reaction with 3 steps
1.1: sulfuric acid / water; methanol / 2 h / Reflux
2.1: acetic acid; sodium nitrite / water / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: tin(II) chloride dihdyrate / ethanol / 60 °C / Inert atmosphere
3.2: 60 °C / Inert atmosphere; Reflux
With tin(II) chloride dihdyrate; sulfuric acid; acetic acid; sodium nitrite; In methanol; ethanol; water;
N-(4-butyl-2-nitrophenyl)acetamide
3663-21-6

N-(4-butyl-2-nitrophenyl)acetamide

4-n-butyl-2-nitroaniline
3663-22-7

4-n-butyl-2-nitroaniline

Conditions
Conditions Yield
With sulfuric acid; In methanol; water; for 2h; Reflux;
96%
With hydrogenchloride; for 17h; Heating;
78.9%
With potassium hydroxide; In ethanol; water; for 1h; Heating;
76%
With hydrogenchloride; Hydrolysis;
With potassium hydroxide; Hydrolysis;
With sodium hydroxide; for 1.3h; Reflux;

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