3663-21-6

Basic information

• Product Name: N-(4-butyl-2-nitrophenyl)acetamide
• Synonyms: N-(4-butyl-2-nitrophenyl)acetamide;N-(4-butyl-2-nitrophenyl)acetamide C12H16N2O3 236.27
• CAS NO: 3663-21-6
• Molecular Formula: C₁₂H₁₆N₂O₃
• Molecular Weight: 236.26704
• EINECS: 222-915-6
• Mol File: 3663-21-6.mol

Chemical Properties

• Boiling Point: 425.7 °C at 760 mmHg
• Flash Point: 211.3 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 1.87E-07mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: N-(4-butyl-2-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-butyl-2-nitrophenyl)acetamide(3663-21-6)
• EPA Substance Registry System: N-(4-butyl-2-nitrophenyl)acetamide(3663-21-6)

Safety Data

• Hazardous Substances Data: 3663-21-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
N-(4-butyl-2-nitrophenyl)acetamide is used as a research compound for studying its interactions with biological systems due to its potential biological activity and unique structural features.
Used in Drug Development:
N-(4-butyl-2-nitrophenyl)acetamide is utilized as a candidate in drug development, given its potential for therapeutic applications that require further research to understand its full pharmacological and toxicological properties.

InChI:InChI=1/C12H16N2O3/c1-3-4-5-10-6-7-11(13-9(2)15)12(8-10)14(16)17/h6-8H,3-5H2,1-2H3,(H,13,15)

Upstream product

• 3663-20-5 N-(4-butylphenyl)acetamide 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 104-13-2 4-Butylaniline 
• 20651-75-6 1-butyl-4-nitro-benzene 
• 104-51-8 1-butylbenzene 
• 1126-78-9 N-(n-butyl)aniline 
• 62-53-3 aniline 

Downstream Products

• 3663-22-7 4-n-butyl-2-nitroaniline 
• 35198-79-9 C₁₅H₂₁N₃O₃S 
• 143621-51-6 4-n-butyl-2-nitrobenzaldehyde 
• 3663-23-8 4-n-butyl-1,2-phenylenediamine 
• 20651-76-7 1-butyl-3-nitro-benzene 
• 5369-17-5 m-(n-butyl)-aniline 
• 3663-24-9 5-n-butyl-1H-benzotriazole 

Relevant articles and documents

A Systematic Study on the Synthesis of n-Butyl Substituted 8-Aminoquinolines

(Chemical Equation Presented) A systematic study on the synthesis of 8-aminoquinoline derivatives with an n-butyl group at each alternate position of the quinoline ring was carried out. Skraup Reaction and its Doebner-von Miller variation were used to obtain most of the quinoline ring except for the 2-butyl-8-aminoquinolines and 4-butyl-8-aminoquinolines where the commercially available methylquinoline derivatives were used as precursors. The structures of the synthesized compounds were characterized by FTIR, 1H-NMR, COSY, 13C-NMR and HRMS spectra.

5-n-butyl-1H-benzotriazole synthesis process

The present invention discloses a 5-n-butyl-1H-benzotriazole synthesis process, which comprises: adding concentrated sulfuric acid to acetic anhydride in a dropwise manner, and adding 4-n-butyl aniline in a dropwise manner to prepare 4-n-butyl acetanilide; adding a mixed acid solution comprising 65% concentrated nitric acid and acetic anhydride to the 4-n-butyl acetanilide in a dropwise manner to synthesize 4-n-butyl-2-nitro acetanilide; synthesizing 4-n-butyl-2-nitroaniline by using the 4-n-butyl-2-nitro acetanilide, 95% ethanol and 40% sodium hydroxide as raw materials; under the effect of a catalyst, using the 4-n-butyl-2-nitroaniline and dehydrated alcohol and sequentially using nitrogen and hydrogen to convert under a closed condition to prepare 4-n-butyl-o-phenylenediamine; and adding the 4-n-butyl-o-phenylenediamine, water and sodium nitrite to an autoclave to synthesize the 5-n-butyl-1H-benzotriazole. According to the present invention, the process equipment is simple, and the product yield is high.

Photochemistry of (2-nitrophenyl)diazomethane studied by the matrix isolation technique. (Nitrophenyl)carbene to (carboxylphenyl)nitrene rearrangement by successive reduction of the nitro group with the carbenic center

Irradiation (λ > 350 nm) of (2-nitrophenyl)diazomethane (1) matrix-isolated in Ar at 10 K provided 2-nitrosobenzaldehyde (3) presumably as a result of intramolecular oxygen migration in (2-nitrophenyl)carbene (2). Upon further irradiation (λ > 350 nm), 3 was decomposed to give a mixture of 2,1-benzisoxazol-3(1H)-one (4) and carbonylcyclopentadiene imine (5) along with CO2. The oxazolone (4) underwent decarboxylation to give 5 upon irradiation with shorter wavelength light (λ > 300 nm) but not at longer wavelength (λ > 350 nm), suggesting 4 is not the direct precursor for 5 in the photolysis of 3. Irradiation (λ > 350 nm) of (4-n-butyl-2-nitrophenyl)diazomethane (1b) under similar conditions resulted in the formation of carbonyloximinocyclohexadienylidene (7) which then produced the oxazolone (4b) and the imine (5b) upon further irradiation, suggesting that a 1,4-biradical generated as a result of abstraction of H at the ortho position by the photoexcited nitroso group was involved in the reaction of 3 forming 4. (2-Carboxyphenyl)nitrene (9) generated by 1,4-OH shift in the 1,4-biradical was postulated as an intermediate leading to 5, and this was actually demonstrated by independent generation of 9 by the photolysis of 2-azidobenzoic acid (8).

Nouveaux diamino-3,4 phenylalcanes et leur transformation en benzimidazolemethanethiols-2

We report five o-phenylenediamines which are substituted by an aliphatic chain containing n carbon atoms (n = 4, 6, 8, 10, 12).We describe a well adapted general synthetic method using Schmidt's reaction.The diamines were then transformed into 2-benzimidazolemethanethiols and their related S-methyl derivatives which structures were checked by (1)H NMR.

Treatment of helminth infections with substituted phenyl-thiourea derivatives

Benzene derivatives of the formula:- STR1 wherein R is an aliphatic hydrocarbon group of 1 to 4 carbon atoms optionally substituted by halogen or alkoxy, R1 is hydrogen or methyl, R2 is hydrogen, halogen, alkyl, alkanoylamino optionally substituted by cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonylamino, alkanoyl, benzoyl or N-methylmethanesulphonylamino, and Y is primary amino or substituted amino, possess anthelmintic and anti-viral activity. New compounds within that formula possess fungicidal properties.