3709-25-9Relevant articles and documents
Photocatalytic Hydromethylation and Hydroalkylation of Olefins Enabled by Titanium Dioxide Mediated Decarboxylation
Zhu, Qilei,Nocera, Daniel G.
supporting information, p. 17913 - 17918 (2020/12/04)
A versatile method for the hydromethylation and hydroalkylation of alkenes at room temperature is achieved by using the photooxidative redox capacity of the valence band of anatase titanium dioxide (TiO2). Mechanistic studies support a radical-based mechanism involving the photoexcitation of TiO2 with 390 nm light in the presence of acetic acid and other carboxylic acids to generate methyl and alkyl radicals, respectively, without the need for stoichiometric base. This protocol is accepting of a broad scope of alkene and carboxylic acids, including challenging ones that produce highly reactive primary alkyl radicals and those containing functional groups that are susceptible to nucleophilic substitution such as alkyl halides. This methodology highlights the utility of using heterogeneous semiconductor photocatalysts such as TiO2 for promoting challenging organic syntheses that rely on highly reactive intermediates.
Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)
Ye, Xiang-Yang,Chen, Stephanie Y.,Nayeem, Akbar,Golla, Rajasree,Seethala, Ramakrishna,Wang, Mengmeng,Harper, Timothy,Sleczka, Bogdan G.,Li, Yi-Xin,He, Bin,Kirby, Mark,Gordon, David A.,Robl, Jeffrey A.
supporting information; experimental part, p. 6699 - 6704 (2011/12/21)
Starting from high throughput screening hit 2-adamantyl acetic acid 3, a series of polycyclic acids have been designed and synthesized as novel, potent, and selective inhibitors of human 11β-HSD-1. Structure-activity relationships of two different regions
Convenient Access to Polysubstituted 1-Indanones by Sc(OTf) 3-Catalyzed Intramolecular Friedel-Crafts Acylation of Benzyl Meldrum's Acid Derivatives
Fillion, Eric,Fishlock, Dan
, p. 4653 - 4656 (2007/10/03)
(Matrix presented) The intramolecular Friedel-Crafts acylation of benzyl Meldrum's acids is catalyzed by Sc(OTf)3 under mild reaction conditions. Several polysubstituted 1-indanones have been prepared.
Studies on the Synthesis of Aphidicolin. The Diels-Alder Route to Spirocyclic Intermediates
Bell, Vivien L.,Holmes, Andrew B.,Hsu, Shih-Ying,Mock, Graham A.,Raphael, Ralph A.
, p. 1507 - 1514 (2007/10/02)
The isopropylidene cyclohexylidenemalonates (6; R1=R2=H; R2=OCH2CH2O; and R1, R2=SCH2CH2S) undergo cycloaddition with butadiene, 2-trimethylsilyloxybuta-1,3-diene, and 3-trimethylsilyloxypenta-2,4-diene to give the corresponding spirocyclic adducts (7; R1