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Vermiculite is a naturally occurring mineral compound known for its ability to retain moisture and nutrients, making it a versatile material in various industries such as agriculture, construction, and horticulture.
Used in Agriculture:
Vermiculite is used as a soil amendment for its water retention and aeration properties, enhancing the growing medium for plants.
Used in Horticulture:
Vermiculite is used as a component in potting mixes, providing aeration and moisture retention for optimal plant growth.
Used in Construction:
Vermiculite is used as an insulating material for attics and walls due to its fire-resistant properties.
Used in Shipping:
Vermiculite is used as a packing material for shipping hazardous substances, taking advantage of its cushioning and moisture retention capabilities.
However, it is important to note that concerns have been raised about the potential health risks associated with vermiculite that has been contaminated with asbestos, leading to regulations and guidelines for its safe use and handling.

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  • 37244-00-1 Structure
  • Basic information

    1. Product Name: vermiculine
    2. Synonyms: vermiculine;(3E,8S,11E,16S)-8,16-Bis(2-oxopropyl)-1,9-dioxa-3,11-cyclohexadecadiene-2,5,10,13-tetrone;(3E,8S,11E,16S)-8,16-Bis(2-oxopropyl)-1,9-dioxacyclohexadeca-3,11-diene-2,5,10,13-tetrone;Vermiculin
    3. CAS NO:37244-00-1
    4. Molecular Formula: C20H24O8
    5. Molecular Weight: 392.402
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 37244-00-1.mol
  • Chemical Properties

    1. Melting Point: 175-177 °C (decomp)
    2. Boiling Point: 437.13°C (rough estimate)
    3. Flash Point: 284.7°C
    4. Appearance: /
    5. Density: 1.2464 (rough estimate)
    6. Vapor Pressure: 4.73E-17mmHg at 25°C
    7. Refractive Index: 1.4430 (estimate)
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: vermiculine(CAS DataBase Reference)
    11. NIST Chemistry Reference: vermiculine(37244-00-1)
    12. EPA Substance Registry System: vermiculine(37244-00-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 37244-00-1(Hazardous Substances Data)

37244-00-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 37244-00-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,2,4 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37244-00:
(7*3)+(6*7)+(5*2)+(4*4)+(3*4)+(2*0)+(1*0)=101
101 % 10 = 1
So 37244-00-1 is a valid CAS Registry Number.
InChI:InChI=1/C20H24O8/c1-13(21)11-17-7-3-15(23)6-10-20(26)28-18(12-14(2)22)8-4-16(24)5-9-19(25)27-17/h5-6,9-10,17-18H,3-4,7-8,11-12H2,1-2H3/b9-5-,10-6+

37244-00-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (3Z,11E)-8,16-Bis(2-oxopropyl)-1,9-dioxacyclohexadeca-3,11-diene- 2,5,10,13-tetrone

1.2 Other means of identification

Product number -
Other names (R)-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazolin-3-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:37244-00-1 SDS

37244-00-1Relevant articles and documents

Macrodiolide Diversification Reveals Broad Immunosuppressive Activity That Impairs the cGAS-STING Pathway

Biltoft, Mette,Jakobsen, Martin R.,Jennet, Kira M.,Kristensen, Tobias F.,Liu, Han,Ottosen, Rasmus N.,Poulsen, Thomas B.,Svenningsen, Esben B.

supporting information, p. 18734 - 18741 (2021/07/19)

The development of new immunomodulatory agents can impact various areas of medicine. In particular, compounds with the ability to modulate innate immunological pathways hold significant unexplored potential. Herein, we report a modular synthetic approach to the macrodiolide natural product (?)-vermiculine, an agent previously shown to possess diverse biological effects, including cytotoxic and immunosuppressive activity. The synthesis allows for a high degree of flexibility in modifying the macrocyclic framework, including the formation of all possible stereoisomers. In total, 18 analogues were prepared. Two analogues with minor structural modifications showed clearly enhanced cancer cell line selectivity and reduced toxicity. Moreover, these compounds possessed broad inhibitory activity against innate immunological pathways in human PBMCs, including the DNA-sensing cGAS-STING pathway. Initial mechanistic characterization suggests a surprising impairment of the STING-TBK1 interaction.

Concise Total Synthesis of (?)-Vermiculine through a Rhodium-Catalyzed C2-Symmetric Dimerization Strategy

Steib, Philip,Breit, Bernhard

, p. 3532 - 3535 (2019/02/19)

A short and efficient synthesis of the C2-symmetric antibiotic (?)-vermiculine by utilizing an enantioselective catalytic one-step dimerization methodology as key-step to construct the core structure is reported. The late-stage modifications feature a double metathesis homologation followed by a double Wacker-type oxidation. These key-steps allowed the synthesis of vermiculine in only seven steps, starting from commercially available building blocks.

Total Synthesis of (-)-Vermiculine

Noda, Atsushi,Aoyagi, Sakae,Machinaga, Nobuo,Kibayashi, Chihiro

, p. 8237 - 8240 (2007/10/02)

Macrodiolide (-)-vermiculine has been synthesized via intramolecular Mitsunobu reaction utilizing a C2 symmetrical diepoxide chiral synthon.

SYNTHESIS OF dl-VERMICULINE VIA CONTROL OF OLEFIN FORMATION

Wakamatsu, Takeshi,Yamada, Satoshi,Ban, Yoshio

, p. 309 - 312 (2007/10/02)

The synthesis of the macrodiolide antibiotic vermiculine 1 has been achieved starting from the enediol(trimethylsilyl enol ether via the macrocyclization of hydroxycarboxylic acid followed by the formation of the requisite trans double bonds.

ALTERNATIVE SYNTHESIS OF (+/-)-VERMICULIN

Traverso, Giorgio,Pirillo, Demetrio,Gazzaniga, Andrea

, p. 461 - 464 (2007/10/02)

The synthesis of (+/-)-vermiculin, 1, is reported.The key step is the condensation of the formyl ester 13 with the acetoacetic dianion to diester 15.

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