3764-87-2Relevant articles and documents
Optimization of copper(I)-catalyzed 1,6-conjugate addition of a methyl group to 17β-acetoxy-4,6-estradien-3-one
Martynow, Jacek,Krupa, Malgorzata,Les, Andrzej,Kutner, Andrzej,Szelejewski, Wieslaw
, p. 846 - 851 (2013/09/03)
7α-Methyl-19-nortestosterone (1) was synthesized from 19-nortestosterone (2) via 17β-acetoxy-4,6-estradien-3-one (4). The critical parameters for the synthesis of compound (1) have been identified. An optimization procedure consisting of an iterative, two-stage reaction response surface analysis was carried out. As a result, the synthesis of the target compound (1) from the intermediate (4) was achieved under the newly determined conditions, in a repeatable manner. This afforded compound (1) in an yield of over 60%, essentially free from the 7β-Me isomer (6), under experimental conditions amenable for scale enhancement.
Method for androgen supplementation
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, (2008/06/13)
A particular group of androgens is not metabolized to their 5α-reduced form in the prostate and other tissues. Thus, administration of these compounds--testosterone derivatives with a non-hydrogen substituent in the 6α or 7α position--allows one to provide androgen supplementation therapy without stimulating abnormal prostate growth. A preferred compound for use in the invention is 7α-methyl-19-nortestosterone.