50606-96-7

Usage

Uses

Used in Pharmaceutical Industry:
4-N-Heptylbenzoyl chloride is used as a synthetic intermediate for the production of 3-O-acyl derivatives. It is particularly utilized in the synthesis of 3-O-acyl betulinic acid derivatives, which have potential applications in the pharmaceutical industry due to their bioactive properties.
Used in Organic Synthesis:
In the field of organic chemistry, 4-N-Heptylbenzoyl chloride serves as a valuable building block for the creation of various complex organic molecules. Its reactivity allows chemists to introduce heptylbenzoyl moieties into different molecular structures, potentially leading to new compounds with unique properties and applications.
Used in Chemical Research:
4-N-Heptylbenzoyl chloride is also employed in chemical research as a tool to study the reactivity of different functional groups and the formation of new chemical bonds. 4-N-HEPTYLBENZOYL CHLORIDE can be used to investigate reaction mechanisms, optimize reaction conditions, and develop new synthetic routes for the production of various organic compounds.

InChI:InChI=1/C14H19ClO/c1-2-3-4-5-6-7-12-8-10-13(11-9-12)14(15)16/h8-11H,2-7H2,1H3

Upstream product

• 38350-87-7 4-heptylbenzoic acid 
• 79-37-8 oxalyl dichloride 
• 1078-71-3 heptylbenzene 

Downstream Products

• 49763-67-9 4-heptylbenzaldehyde 
• 79945-47-4 4-(4-n-heptylbenzoyloxy)benzoic acid 
• 600723-63-5 4-heptyl-N-(2-methyl-2-phenethyl-benzo[1,3]dioxol-5-yl)-benzamide 
• 1352429-32-3 N-(2-(4-ethylphenylamino)benzo[d]oxazol-5-yl)-4-heptylbenzamide 
• 1078-71-3 heptylbenzene 
• 64408-99-7 4-Heptyl-thiobenzoic acid S-(4-cyano-phenyl) ester 
• 64408-98-6 4-Heptyl-thiobenzoic acid S-(4-hexyloxy-phenyl) ester 
• 61733-47-9 4-n-heptylbenzoic acid 4'-(4-isopropylphenyl)-phenyl ester 

Relevant academic research and scientific papers

Ni-Catalyzed Aryl Sulfide Synthesis through an Aryl Exchange Reaction

A Ni-catalyzed aryl sulfide synthesis through an aryl exchange reaction between aryl sulfides and a variety of aryl electrophiles was developed. By using 2-pyridyl sulfide as a sulfide donor, this reaction achieved the synthesis of aryl sulfides without using odorous and toxic thiols. The use of a Ni/dcypt catalyst capable of cleaving and forming aryl-S bonds was important for the aryl exchange reaction between 2-pyridyl sulfides and aryl electrophiles, which include aromatic esters, arenol derivatives, and aryl halides. Mechanistic studies revealed that Ni/dcypt can simultaneously undergo oxidative additions of aryl sulfides and aromatic esters, followed by ligand exchange between the generated aryl-Ni-SR and aryl-Ni-OAr species to furnish aryl exchanged compounds.

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold

Tuberculosis (TB) remains a significant global health problem for which new therapeutic options are sorely needed. The ability of the causative agent, Mycobacterium tuberculosis, to reside within host macrophages and form biofilm-like communities contributes to the persistent and drug-tolerant nature of the disease. Compounds that can prevent or reverse the biofilm-like phenotype have the potential to serve alongside TB antibiotics to overcome this tolerance, and decrease treatment duration. Using Mycobacterium smegmatis as a surrogate organism, we report the identification of two new 2-aminoimidazole compounds that inhibit and disperse mycobacterial biofilms, work synergistically with isoniazid and rifampicin to eradicate preformed M. smegmatis biofilms in vitro, are nontoxic toward Galleria mellonella, and exhibit stability in mouse plasma.

ALKOXYSILANE COMPOUND, LIQUID CRYSTAL ALIGNING AGENT, LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY ELEMENT

Provided are an alkoxysilane that is used as a material for liquid crystal alignment films or the like, and a method for producing said alkoxysilane. An alkoxysilane represented by formula (1), wherein a ring structure is linked by an amide bond. (In the formula, Z1, Z2 and Z3 each represent a linear or branched C1-4 hydrocarbon group or the like; Z4 represents H, a methyl group or the like; Y1 represents a single bond, -C(CH3)=CH- or the like; Cy1 represents a phenylene group or the like; Cy2 represents a phenylene group or the like; Z5 represents H, a linear or branched C1-18 hydrocarbon group or the like; a represents an integer of 1-18; m represents 1 or 2; and n represents 0, 1 or 2.)

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus

Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) infections are growing global health concerns. Structure-activity relationships of phenylthiazoles as a new antimicrobial class have been addressed. We present 10 thiazole derivatives that exhibit strong activity against 18 clinical strains of MRSA and VRSA with acceptable PK profile. Three derivatives revealed an advantage over vancomycin by rapidly eliminating MRSA growth within 6 h, and no derivatives are toxic to HeLa cells at 11 μg/mL.

SYNTHESIS AND LIQUID CRYSTAL PROPERTIES OF SUBSTITUTED 5-(ARYLCARBONYLOXY)-2-(p-CYANOPHENYL)PYRIMIDINES

Liquid crystal p-substituted benzoates, biphenylcarboxylates, and benzoyloxybenzoates were obtained on the basis of 5-hydroxy-2-(p-cyanophenyl)pyrimidine.The development of nematogenicity by the esters due to the p-cyanophenyl grouping was noted, and the appearance of the smectic mesophase by the variation of the ring framework of the acid fragment of the molecule was investigated.

Synthesis of 20-Carbaldehydes and 20-Carbonitriles of the Pregnane Series Starting with (20S)-20-Hydroxymethylpregna-1,4-dien-3-one

An efficient six-step approach to 3-protected (20S)-3β-hydroxypregna-1,5-diene-20-carbaldehydes 8 with potential importance in the synthesis of vitamin D analogues was developed starting with (20S)-20-hydroxymethylpregna-1,4-dien-3-one (1).Oxidation of the 22-hydroxy group of 1 by means of periodinane 2 (Dess-Martin reagent) furnished the aldehyde 3 without epimerization. 3 was protected selectively at C-22 as dimethyl acetal 5.Isomerization to 6 and subsequent reduction of the 3-carbonyl group with calcium borohydride furnished the 3β-alcohol 7a with high stereoselectivity.Cleavage of the acetal to 8a occurred in a homogeneous solution of acetic acid in the presence of small amounts of water and trifluoroacetic acid.After protection of the 3-OH group 8b-d were obtained in 54percent overall yield.The in situ generated aldehyde N,N-dimethylhydrazones of 3, 8a, and 8b were converted in high yields with excellent chemoselectivity into the nitriles 12, 15a, and 15b with magnesium monoperoxyphthalate hexahydrate.The uniform (20S) stereochemistry of 3 and 8a-d was elucidated by 1H-NMR investigations. - Key Words: Pregnanes / Steroids

Synthesis of Unbranched 4-Alkylbenzaldehydes

The preparation of unbranched 4-alkylbenzaldehydes free of positional and branched-chain isomers by different methods is described.A one-step preparation of the aldehydes is reported which involves the direct hydrogenation of a Friedel-Craft's complex in the presence of Pd/C catalyst.

The Synthesis of Fluorine Containing Phenyl Benzoates and Their Properties as Liquid Crystals

A new series of fluorine containing phenyl benzoates has been synthesized and the transition temperatures of these compounds have been determined.A series of 4-trifluoromethylphenyl 4-n-alkylbenzoates showed no liquid crystalline behaviour, but the 4-trifluoromethylphenyl 4-n-alkoxybenzoates series, with six carbons or more in alkoxy chain, was mesomorphic.The 4-cyanophenyl 4-perfluoroalkylbenzoates showed smectic liquid crystalline properties.