392715-25-2

Basic information

• Product Name: L-Histidine, N-[[[(4-methylphenyl)sulfonyl]amino]carbonyl]-b-alanyl-
• CAS NO: 392715-25-2
• Molecular Formula: C17H21N5O6S
• Molecular Weight: 423.45
• Mol File: 392715-25-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Histidine, N-[[[(4-methylphenyl)sulfonyl]amino]carbonyl]-b-alanyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Histidine, N-[[[(4-methylphenyl)sulfonyl]amino]carbonyl]-b-alanyl-(392715-25-2)
• EPA Substance Registry System: L-Histidine, N-[[[(4-methylphenyl)sulfonyl]amino]carbonyl]-b-alanyl-(392715-25-2)

Safety Data

• Hazardous Substances Data: 392715-25-2(Hazardous Substances Data)

Upstream product

• 4083-64-1 Tosyl isocyanate 
• 305-84-0 Carnosine 

Downstream Products

• 276245-72-8 C₂₅H₃₀N₈O₈S₂ 
• 1027583-08-9 C₂₄H₂₆N₈O₇S₂ 

Relevant articles and documents

4-Toluenesulfonylureido derivatives of amines, amino acids and dipeptides: A novel class of potential antitumor agents

The screening of a series of arylsulfonylureido derivatives of amines (such as histamine, or dopamine), aliphatic/aromatic amino acids (such as Gly, β-Ala, Val, Lys, Arg, Phe, Tyr, DOPA, etc.) and dipeptides (such as GlyGly, β-AlaHis) led to the identification of three derivatives that possess tumor growth inhibitory properties against several leukemia, non-small cell lung, ovarian, melanoma, colon, CNS, renal, and breast cancer cell lines in vitro. The new derivatives were prepared by reaction of 4-toluenesulfonyl isocyanate with (protected) amines, amino acids or dipeptides. The mechanism of antitumor action with these new derivatives is not known at the moment but it may imply uncoupling of mitochondria, as for the structurally related diarylsulfonylurea sulofenur, an investigational anticancer agent. Copyright (C) 2000 Elsevier Science B.V.