39620-04-7

Basic information

• Product Name: 2-Amino-3-chloropyridine
• Synonyms: 2-AMINO-3-CHLOROPYRIDINE;3-CHLORO-PYRIDIN-2-YLAMINE;3-CHLORO-2-PYRIDINYLAMINE;IFLAB-BB F3099-7175;AURORA 15088;OTAVA-BB BB7110951381;3-chloro-2-aminopyridine97%;3-CHLOROPYRIDIN-2-AMINE
• CAS NO: 39620-04-7
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• Product Categories: PYRIDINE;pharmacetical;Pyridine series;Amines;Pyridines;Heterocycle-Pyridine series;amine| alkyl chloride
• Mol File: 39620-04-7.mol

Chemical Properties

• Melting Point: 59-62℃
• Boiling Point: 206.953 °C at 760 mmHg
• Flash Point: 78.963 °C
• Appearance: /
• Density: 1.327 g/cm³
• Vapor Pressure: 0.231mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.14±0.36(Predicted)
• CAS DataBase Reference: 2-Amino-3-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-chloropyridine(39620-04-7)
• EPA Substance Registry System: 2-Amino-3-chloropyridine(39620-04-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22-20/21/22
• Safety Statements: 26-36/37/39-39-36/37-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 39620-04-7(Hazardous Substances Data)

Usage

Chemical Properties

Light green solid

InChI:InChI=1/C5H5ClN2/c6-4-2-1-3-8-5(4)7/h1-3H,(H2,7,8)

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 64-10-8 phenyl carbamate 
• 504-29-0 2-aminopyridine 

Downstream Products

• 77200-37-4 <3,3'-bipyridine>-2,2'-diamine 
• 481049-41-6 8-chloro-2-(4'-tolyl)imidazo<1,2-a>pyridine 
• 77332-89-9 2-iodo-3-pyridyl chloride 
• 885-70-1 5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one 
• 481049-31-4 8-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine 
• 481049-37-0 C₁₄H₁₁ClN₂O 
• 481049-49-4 C₁₄H₈ClN₃ 
• 168837-40-9 C₁₄H₁₁ClN₂O 
• 481049-57-4 C₁₄H₈ClN₃ 
• 481048-69-5 C₂₃H₂₂ClN₅O 
• 481048-70-8 C₂₈H₃₂N₆O 
• 481048-71-9 C₂₇H₃₀N₆O 
• 481049-38-1 C₁₅H₁₁ClN₂O₂ 
• 481049-39-2 C₁₇H₁₃ClN₂O₂ 

Relevant articles and documents

3-Substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design

We report the use of 3-substituted 2-isocyanopyridines as convertible isocyanides in Ugi four-component reactions. TheN-(3-substituted pyridin-2-yl)amide Ugi products can be cleaved by amines, alcohols, and water with Zn(OAc)2as a catalyst. In addition, the applicability of the method was demonstrated in constrained di-/tripeptides bearing acid and base sensitive protective groups obtainedviaUgi-4CR post-condensation modifications.

PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS

The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).

A method for preparation of 2-amino-5-chloro-pyridine

The invention provides a method for preparation of 2-amino-5-chloro-pyridine and belongs to the technical field of fine organic synthesis. 2-amino-5-chloro-pyridine is prepared by adopting 2-aminopyridine as a raw material and using hydrochloric acid and sodium hypochlorite for an oxidative chlorination reaction. The method mainly includes the following steps: at 10 DEG C, slowly and dropwise adding a certain amount of concentrated hydrochloric acid in a mixed solution of 2-aminopyridine and NaClO, conducting a reaction at constant temperature for 2 hours, increasing the temperature to 25 DEG C for continuing the reaction for 4 hours, regulating the pH of a reaction product, extracting the reaction product with dichloroethane, and conducting separation to obtain 2-amino-5-chloro-pyridine. The yield of 2-amino-5-chloro-pyridine is up to 72%. The method has the advantages that the cheap NaClO solution generated by chlorination of tail gas by chlorine gas and hydrochloric acid are used as chlorinating agents, the cost is thus reduced, and the comprehensive utilization of resources is achieved; the reaction conditions are mild, direct use of chlorine gas is avoided, safety is high, and pollution is little.

Regioselective preparation of pyridin-2-yl ureas from 2-chloropyridines catalyzed by Pd(0)

The palladium-catalyzed ureidation reaction of 2-chloropyridines can be regioselectively performed in good yield, with both aryl and aliphatic ureas, using xantphos as the ligand, Pd(OAc)2 as the source of palladium, NaOt-Bu/H2O or N