77332-89-9

Basic information

• Product Name: 3-Chloro-2-iodopyridine
• Synonyms: 3-Chloro-2-iodopyridine;Pyridine, 3-chloro-2-iodo-
• CAS NO: 77332-89-9
• Molecular Formula: C₅H₃ClIN
• Molecular Weight: 239.44149
• Product Categories: pharmacetical;Pyridine series;Amines;Pyridines;Heterocycle-Pyridine series
• Mol File: 77332-89-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 245.001 °C at 760 mmHg
• Flash Point: 101.973 °C
• Appearance: /
• Density: 2.052 g/cm³
• Vapor Pressure: 0.046mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-Chloro-2-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2-iodopyridine(77332-89-9)
• EPA Substance Registry System: 3-Chloro-2-iodopyridine(77332-89-9)

Safety Data

• Hazardous Substances Data: 77332-89-9(Hazardous Substances Data)

Usage

Uses

3-Chloro-2-iodopyridine is used in the preparation of silyl-mediated halogen/halogen exchange reactions of pyridines and other heterocycles.

InChI:InChI=1/C5H3ClIN/c6-4-2-1-3-8-5(4)7/h1-3H

Upstream product

• 626-60-8 3-Chloropyridine 
• 39620-04-7 2-amino-3-chloropyridine 
• 2402-77-9 2,3-dichloro-pyridine 
• 96424-68-9 2-bromo-3-chloropyridine 
• 7553-56-2 iodine 

Downstream Products

• 54231-36-6 4-(3-chloropyridin-2-yl)morpholine 
• 1395412-74-4 N-(3,6'-dichloro-[2,4]bipyridinyl-3'-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide 
• 749875-02-3 3-chloro-2-(trifluoromethyl)pyridine-4-carboxylic acid 

Relevant articles and documents

Continuous flow magnesiation of functionalized heterocycles and acrylates with TMPMgCl·LiCl

A flow procedure for the metalation of functionalized heterocycles (pyridines, pyrimidines, thiophenes, and thiazoles) and various acrylates using the strong, non-nucleophilic base TMPMgCl·LiCl is reported. The flow conditions allow the magnesiations to be performed under more convenient conditions than the comparable batch reactions, which often require cryogenic temperatures and long reaction times. Moreover, the flow reactions are directly scalable without further optimization. Metalation under flow conditions also allows magnesiations that did not produce the desired products under batch conditions, such as the magnesiation of sensitive acrylic derivatives. The magnesiated species are subsequently quenched with various electrophiles, thereby introducing a broad range of functionalities. Go with the flow: Flow conditions allow a practical metalation of functionalized heterocycles and various acrylates in the presence of the base TMPMgCl·LiCl (TMP=2,2,6,6-tetramethylpiperidyl). More convenient temperatures and very fast reaction times can usually be achieved by applying the flow conditions. Sensitive acrylic derivatives can be magnesiated under flow conditions. Furthermore, the flow reactions are readily scalable without further optimization.

CHEMICAL COMPOUNDS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain

GLYCINE TRANSPORTER INHIBITOR

The present invention provides a compound represented by the following formula or a pharmaceutically acceptable salt of the compound or a hydrate of the compound or the salt, which is useful for the prevention or treatment of diseases such as schizophreni