40182-20-5

Basic information

• Product Name: O-BENZYLBENZAMIDE
• Synonyms: AKOS AKM00157;O-BENZYLBENZAMIDE
• CAS NO: 40182-20-5
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.26
• Mol File: 40182-20-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: O-BENZYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: O-BENZYLBENZAMIDE(40182-20-5)
• EPA Substance Registry System: O-BENZYLBENZAMIDE(40182-20-5)

Safety Data

• Hazardous Substances Data: 40182-20-5(Hazardous Substances Data)

Upstream product

• 56153-61-8 2-benzyl-benzonitrile 
• 612-35-1 2-Benzylbenzoic acid 
• 592-87-0 lead(II) thiocyanate 
• 1586-00-1 2-(benzyl)benzyl alcohol 
• 612-13-5 2-cyanobenzyl chloride 
• 22115-41-9 2-(bromomethyl)benzonitrile 
• 71-43-2 benzene 
• 55-21-0 benzamide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 100-39-0 benzyl bromide 
• 100-47-0 benzonitrile 
• 40182-21-6 3-(3-oxo-1-phenyl-1,3-dihydro-isobenzofuran-1-yl)-3-phenyl-2,3-dihydro-isoindol-1-one 
• 28059-64-5 2-benzylaniline 
• 6637-53-2 3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one 

Relevant articles and documents

METHOD FOR PRODUCING AMINE THROUGH REDUCTION OF AMIDE

The present invention provides a method for producing primary amines and secondary amines, the method being characterized by reducing a primary amide or a secondary amide in the presence of a reducing agent and an organic metal halide of a group-2 element.

Preparation method of o-amino diphenylmethane

The invention relates to a preparation method of o-amino diphenylmethane, and belongs to the technical field of pharmaceutical synthesis. The preparation method comprises steps as follows: o-cyano-diphenylmethane is prepared from o-cyanobenzyl chloride and benzene through a reaction, then o-cyano-diphenylmethane is hydrolyzed in an aqueous solution of ethanediol, o-amide-diphenylmethane is obtained and is subjected to a rearrangement reaction with sodium hypochlorite, reduced-pressure distillation is performed, and o-amino diphenylmethane is obtained. O-amino diphenylmethane prepared with themethod is high in yield, the yield can reach 89% or above, meanwhile, a finished o-amino diphenylmethane product is high in purity, the purity can reach 99% or above, product quality is good, and defects of low purity and low yield of the product prepared with a traditional method are overcome. Besides, the preparation method is simple to operate and needs few steps, impurities in the product areeasy to separate and remove, and large-scale industrial production is facilitated.

Solvent free acid catalysed direct N-alkylation of amines with alcohols using Al grafted MCM-41

The catalytic activity of Al grafted MCM-41 (Al-MS) was explored for solvent free acid catalysed direct N-alkylation of amines using alcohols as green alkylating agent to establish a clean method for synthesis of N-alkylated amines. The study revealed that acidity of Al-MS catalyst, reaction conditions and substrate's (amines and alcohols) nature are important factors influencing the N-alkylation reaction. The Al grafted MCM-41 with Si/Al molar ratio of 5 showed excellent activity for N-alkylation of amines with alcohols. The reusability of spent catalyst regenerated by simple washing with acetone was demonstrated for subsequent four reaction cycles.

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere via N-H imines as an intramolecular directing group

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere was developed starting from carbonitriles and Grignard reagents via N-H imine intermediates. The present process is characterized by the following two-step sequence in a one-pot manner: (1) addition of Grignard reagents to carbonitriles to form N-H imines and (2) benzylic C-H oxygenation (C=O bond formation) triggered by 1,5-hydrogen atom transfer with transient iminyl copper species.