56153-61-8

Usage

Uses

Used in Pharmaceutical Industry:
o-Benzylbenzonitrile is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs and medicinal compounds.
Used in Dye Industry:
o-Benzylbenzonitrile is used as a building block for the synthesis of dyes, playing a role in the creation of various colorants for different applications.
Used in Fragrance Industry:
o-Benzylbenzonitrile is used as a fragrance ingredient, capitalizing on its mild, almond-like odor to enhance the scent profiles of various products.
Used in Material Science:
o-Benzylbenzonitrile is studied as a precursor to create new materials and polymers with unique properties, potentially leading to advances in material technology and innovation.

Upstream product

• 529-19-1 2-Methylbenzonitrile 
• 623-26-7 terephthalonitrile 
• 98689-33-9 tetramethylammonium triphenylbenzylborate 
• 103606-45-7 3-(benzylimino)isobenzofuran-1-one 
• 2042-37-7 o-cyanobromobenzene 
• 100-39-0 benzyl bromide 
• 770-09-2 benzyltrimethylsilane 
• 91-15-6 phthalonitrile 
• 28493-54-1 benzyltributyltin 
• 7664-41-7 ammonia 
• 108-86-1 bromobenzene 
• 6393-50-6 α-lithiophenylacetonitrile 
• 591-50-4 iodobenzene 
• 92-71-7 2,5-diphenyloxazole 

Downstream Products

• 109845-54-7 (2-benzoylphenyl)(pyridin-2-yl)methanone 
• 61608-94-4 1-(2-(phenylmethyl)phenyl)ethanone 
• 4919-84-0 2-benzyl-benzophenone 
• 854678-86-7 1-(2-benzyl-phenyl)-propan-1-one 
• 7702-22-9 2-benzyl-4'-methoxy-benzophenone 
• 18793-94-7 2-benzyl-4'-chloro-benzophenone 
• 612-35-1 2-Benzylbenzoic acid 
• 40182-20-5 2-benzylbenzamide 
• 406174-56-9 (2-benzylphenyl)methanamine 
• 390-30-7 2-benzyl-4'-fluoro-benzophenone 
• 97114-08-4 1,2-Di-<2-cyan-phenyl>-1,2-diphenyl-aethan 
• 79365-07-4 2-benzylbenzaldehyde azine 
• 102553-08-2 2-Benzylphenyl-cyclohexylketon 
• 56153-62-9 2-Benzyldiphenylmethylenimin 

Relevant academic research and scientific papers

Nitrile Synthesis via Desulfonylative-Smiles Rearrangement

Herein, we designed a simple nitrile synthesis from N-[(2-nitrophenyl)sulfonyl]benzamides via base-promoted intramolecular nucleophilic aromatic substitution. The process features redox-neutral conditions as well as no requirement of toxic cyanide species and transition metals. Our process shows broad scope and various functional group compatibility, affording a variety of (hetero)aromatic nitriles in good to excellent yields.

Desulfurative Ni-Catalyzed Reductive Cross-Coupling of Benzyl Mercaptans/Mercaptoacetates with Aryl Halides

The C-S activation and sulfur removal from native thiols is challenging, which limits their application as feedstock materials in organic synthesis despite their natural abundance. Herein, we introduce a per-/polyfluoroaryl moiety, which serves as a redox-active scaffold, into sp3-hybridized thiols to activate the C-S bond. Using a Ni catalyst with MgBr2 as an additive, the S group can be removed to yield an aliphatic radical that can react with an aryl halide in a reductive cross-coupling.

Photo-Ni-Dual-Catalytic C(sp2)-C(sp3) Cross-Coupling Reactions with Mesoporous Graphitic Carbon Nitride as a Heterogeneous Organic Semiconductor Photocatalyst

The synergistic combination of a heterogeneous organic semiconductor mesoporous graphitic carbon nitride (mpg-CN) and a homogeneous nickel catalyst with visible-light irradiation at room temperature affords the C(sp2)-C(sp3) cross-co

Preparation method of o-amino diphenylmethane

The invention relates to a preparation method of o-amino diphenylmethane, and belongs to the technical field of pharmaceutical synthesis. The preparation method comprises steps as follows: o-cyano-diphenylmethane is prepared from o-cyanobenzyl chloride and benzene through a reaction, then o-cyano-diphenylmethane is hydrolyzed in an aqueous solution of ethanediol, o-amide-diphenylmethane is obtained and is subjected to a rearrangement reaction with sodium hypochlorite, reduced-pressure distillation is performed, and o-amino diphenylmethane is obtained. O-amino diphenylmethane prepared with themethod is high in yield, the yield can reach 89% or above, meanwhile, a finished o-amino diphenylmethane product is high in purity, the purity can reach 99% or above, product quality is good, and defects of low purity and low yield of the product prepared with a traditional method are overcome. Besides, the preparation method is simple to operate and needs few steps, impurities in the product areeasy to separate and remove, and large-scale industrial production is facilitated.

Cobalt-Catalyzed Formation of Functionalized Diarylmethanes from Benzylmesylates and Aryl Halides

A simple cobalt-catalyzed reductive coupling protocol allowing the synthesis of functionalized diarylmethanes from benzyl mesylate is described. The possibility to directly use the benzyl alcohol as a result of a two-step reaction is also presented. This method tolerates a variety of functional groups. A benzyl radical is likely involved. (Figure presented.).

Synthesis of bench-stable solid triorganoindium reagents and reactivity in palladium-catalyzed cross-coupling reactions

Bench-stable solid triorganoindium compounds have been prepared by coordination with 4-(dimethylamino)pyridine (DMAP). The solid R3In(DMAP) complexes are obtained from the corresponding solution of R3In in quantitative yield and can

Radical-Based C?C Bond-Forming Processes Enabled by the Photoexcitation of 4-Alkyl-1,4-dihydropyridines

We report herein that 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) can directly reach an electronically excited state upon light absorption and trigger the generation of C(sp3)-centered radicals without the need for an external photocatalyst. Selective excitation with a violet-light-emitting diode turns alkyl-DHPs into strong reducing agents that can activate reagents through single-electron transfer manifolds while undergoing homolytic cleavage to generate radicals. We used this photochemical dual-reactivity profile to trigger radical-based carbon–carbon bond-forming processes, including nickel-catalyzed cross-coupling reactions.

Visible-Light-Mediated Aromatic Substitution Reactions of Cyanoarenes with 4-Alkyl-1,4-dihydropyridines through Double Carbon-Carbon Bond Cleavage

Novel aromatic substitution reactions of cyanoarenes with 4-alkyl-1,4-dihydropyridines as alkylating reagents in the presence of a catalytic amount of a photoredox catalyst proceed smoothly to give the corresponding alkyl-substituted arenes in good to high yields. The present reaction system realizes a novel C-C bond-forming reaction between two fragments generated from the C-C bond-cleavage reactions of two independent substrates.

Cobalt-Catalyzed Reductive Cross-Coupling Between Benzyl Chlorides and Aryl Halides

A new protocol for the direct reductive cobalt-catalyzed arylation of benzyl chlorides has been developed in order to form functionalized diarylmethanes. A variety of reactive groups either on the aryl or the benzyl halide was employed. This represents the first cobalt-catalyzed reductive cross-coupling which does not require any ligand and pyridine. A reaction pathway is proposed involving a radical benzyl species. (Figure presented.).

Efficient synthesis of diarylmethane derivatives by PdCl2 catalyzed cross-coupling reactions of benzyl chlorides with aryl boronic acids in aqueous medium

The research provides a simple and efficient method for preparing diarylmethane derivatives using the cross-coupling reaction of benzyl chlorides and aryl boronic acids catalyzed by palladium chloride in DMF aqueous solution without additional ligand.