41927-54-2

Basic information

• Product Name: 5-methyl-2,4-diphenyl-2,4-dihydro-3H-pyrazol-3-one
• Synonyms: 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2,4-diphenyl-
• CAS NO: 41927-54-2
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.2952
• Mol File: 41927-54-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 437.5°C at 760 mmHg
• Flash Point: 218.4°C
• Density: 1.15g/cm³
• Vapor Pressure: 7.43E-08mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 5-methyl-2,4-diphenyl-2,4-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2,4-diphenyl-2,4-dihydro-3H-pyrazol-3-one(41927-54-2)
• EPA Substance Registry System: 5-methyl-2,4-diphenyl-2,4-dihydro-3H-pyrazol-3-one(41927-54-2)

Safety Data

• Hazardous Substances Data: 41927-54-2(Hazardous Substances Data)

Upstream product

• 89-25-8 edaravone 
• 101-97-3 Ethyl 2-phenylethanoate 
• 5413-05-8 ethyl 2-phenylacetoacetate 
• 100-63-0 phenylhydrazine 
• 201230-82-2 carbon monoxide 

Relevant articles and documents

Base promoted direct C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts

A metal-free approach for the C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts was developed. The reaction proceeded smoothly at room temperature in the presence of DMAP (4-dimethylaminopyridine). As a result, a wide range of desir

Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base

We synthesized various 3-methyl-1-phenyl-5-pyrazolone (edaravone) derivatives and evaluated their oxidation potential and hydroxyl radical scavenging activity. It was found 3-methyl-1-(pyridin-2-yl)-5-pyrazolone had a much higher ability to scavenge the radical than did edaravone itself. Its efficient radical scavenging activity was assumed to be due to the increase of its anion form, an active form, by a hydrogen-bonded intramolecular base.

A novel route to 2,3-pyrazol-1(5H)-ones via palladium-catalyzed carbonylation of 1,2-diaza-1,3-butadienes

Figure presented A novel Pd(0)-catalyzed carbonylation of both isolable 1,2-diaza-1,3-butadienes and those generated in situ by extrusion of SO2 and CO2 from heterocyclic precursors is described. The reaction proceeds at room temperature to 110°C under 1-2 atm of CO to afford 2,3-pyrazol-1(5H)-ones in good to excellent yields. The effect of catalyst structure and stability on the carbonylation reaction is evaluated.