420-37-1

Basic information

• Product Name: TRIMETHYLOXONIUM TETRAFLUOROBORATE
• Synonyms: TRIMETHYLOXONIUM TETRAFLUOROBORATE;trimethyl-oxoniutetrafluoroborate(1-);trimethyloxonium tetrafluoroborate(1-);Trimethyloxonium tetrafluoroborate 98+%;Trimethyloxoniumtetrafluoroborate,C24%min;Trimethyloxoniumtetrafluoroborate,min.95%;Oxonium, trimethyl-, tetrafluoroborate(1-);Trimethyloxonium tetrafluoroborate 98%
• CAS NO: 420-37-1
• Molecular Formula: BF₄*C₃H₉O
• Molecular Weight: 147.91
• EINECS: 206-994-4
• Product Categories: B (Classes of Boron Compounds);Iodonium Sulfonium & Oxonium Compounds;Oxonium Compounds;Tetrafluoroborates;Alkyl Transfer;C-X Bond Formation (Non-Halogen);Synthetic Reagents;halometallate salts
• Mol File: 420-37-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 200 °C
• Appearance: White to off-white/Crystals
• Storage Temp.: 2-8°C
• Solubility: Soluble in nitrobenzene, nitromethane, chloroform, hot acetone,
• Sensitive: Moisture Sensitive
• BRN: 3597303
• CAS DataBase Reference: TRIMETHYLOXONIUM TETRAFLUOROBORATE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIMETHYLOXONIUM TETRAFLUOROBORATE(420-37-1)
• EPA Substance Registry System: TRIMETHYLOXONIUM TETRAFLUOROBORATE(420-37-1)

Safety Data

• Hazard Codes: C
• Statements: 14-34
• Safety Statements: 26-36/37/39-43-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• F: 3-10-21
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 420-37-1(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white crystals

Uses

Different sources of media describe the Uses of 420-37-1 differently. You can refer to the following data:
1. Trimethyloxonium Tetrafluoroborate is a trialkylated oxonium used as a methylation agent in organic synthesis.
2. Trimethyloxonium tetrafluoroborate act as a avmethylating agent and activates C-X multiple bonds. It is involved in the esterification of polyfunctional carboxylic acids. It acts as a catalyst in the polymerization of cyclic sulfides and ethers. Further, it is used in Beckmann rearrangement of oximes.
3. Reagent for the methylation of hydroxyl groups recently used in a complex, multistep synthesis directed towards spirastrellolide, a marine natural product.

InChI:InChI=1/C3H9O.B.4FH/c1-4(2)3;;;;;/h1-3H3;;4*1H/q+1;+3;;;;/p-4

Upstream product

• 186581-53-3 diazomethane 
• 115-10-6 Dimethyl ether 
• 623-73-4 diazoacetic acid ethyl ester 
• 368-39-8 triethyloxonium fluoroborate 
• 593-53-3 Methyl fluoride 
• 460-13-9 propyl fluoride 
• 75-09-2 dichloromethane 
• 18346-68-4 dimethoxymethylium tetrafluoroborate 
• 109-63-7 boron trifluoride diethyl etherate 
• 33613-52-4 dimethylphenyl sulfonium tetrafluoroborate 
• 74-88-4 methyl iodide 

Downstream Products

• 34684-49-6 3,4-dimethyl-2-phenethyl-thiazolidine 
• 52855-95-5 N-tert-butyl-acetimidic acid methyl ester 
• 627-42-9 2-chloroethyl methyl ether 
• 92912-10-2 methyl (E)-8-methyl-4,8-nonadienoate 
• 92912-11-3 methyl (E)-7,7-dimethyl-4,8-nonadienoate 
• 92912-12-4 methyl (E)-8-methylene-4,9-decadienoate 
• 92912-07-7 methyl (E)-4,8-nonadienoate 
• 10065-72-2 L-Alanine methyl ester 
• 71785-66-5 (R)-α-(3-Pyridylmethyl)alanin-methylester 

Relevant articles and documents

Reactions of nitrilium salts with indole and pyrrole and their derivatives in the synthesis of imines, ketones and secondary amines

Abstract Reactions of N-methyl- and N-ethyl-nitrilium salts with indole and pyrrole and their derivatives yield imines or imine salts in good yields. The related imines are obtained from the salts after careful basification and hydrolysis of the imine salts or the imines by heating with aqueous base give the related ketones in good yields. Alternatively, the imine salts can be reduced using sodium borohydride in methanol to give the related secondary amines.

SUBSTITUTED IMIDAZOHETEROCYCLE DERIVATIVES

The present invention provides substituted imidazoheterocycles having the general structure of formula (I), wherein Y is chosen from -O-, -OCRgRh-, -CRgRhO-, -CRgRh-, -(CRgRh)2-, -NRi-, -CRgRhNRi- and -NRiCRgRh-. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

Process for preparing derivatives of the taxoid family

The present invention relates to a novel process for preparing dialkoxy derivatives of the taxoid family by direct alkylation of the two positions 7 and 10 of deacetylbaccatin or derivatives thereof which are esterified in position 13.