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2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1,3,2-Dioxaborolane,2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl- Manufacturer/High quality/Best price/In stock

    Cas No: 425378-68-3

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  • 425378-68-3 Structure
  • Basic information

    1. Product Name: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER
    2. Synonyms: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER;2-(2-FLUORO-5-NITROPHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLANE;2-Fluoro-5-nitrobenzeneboronic acid, pinacol ester
    3. CAS NO:425378-68-3
    4. Molecular Formula: C12H15BFNO4
    5. Molecular Weight: 267.06
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 425378-68-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER(425378-68-3)
    11. EPA Substance Registry System: 2-FLUORO-5-NITROPHENYLBORONIC ACID PINACOL ESTER(425378-68-3)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 425378-68-3(Hazardous Substances Data)

425378-68-3 Usage

Uses

2-Fluoro-5-nitrophenylboronic acid, pinacol ester

Check Digit Verification of cas no

The CAS Registry Mumber 425378-68-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,5,3,7 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 425378-68:
(8*4)+(7*2)+(6*5)+(5*3)+(4*7)+(3*8)+(2*6)+(1*8)=163
163 % 10 = 3
So 425378-68-3 is a valid CAS Registry Number.

425378-68-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Fluoro-5-Nitrophenylboronic Acid Pinacol Ester

1.2 Other means of identification

Product number -
Other names 2-(2-Fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:425378-68-3 SDS

425378-68-3Relevant articles and documents

INHIBITORS OF TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) AND USES THEREOF

-

Paragraph 00297, (2021/12/28)

Provided herein are compounds of Formula (I''), Formula (I'), Formula (I), Formula (II'), and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and

HETEROCYCLIC COMPOUNDS AS BET INHIBITORS

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Paragraph 0290; 0294, (2020/05/29)

Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.

Pyridine N-oxidation derivative as well as preparation method and application thereof

-

Paragraph 0611; 0618-0620, (2019/08/06)

The invention relates to a pyridine N-oxidation derivative as well as a preparation method and an application thereof, in particular to a compound shown in a general formula (I), a preparation methodof the compound, pharmaceutical composition containing the compound and an application of the compound as a BRD4 inhibitor in treating related diseases such as cancer, inflammation, chronic liver diseases, diabetes, cardiovascular diseases, AIDS and the like, wherein in the general formula (I), all substituent groups are the same as definitions in the description.

Discovery of imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 subtype selective agonists for the treatment of anxiety

Russell, Michael G. N.,Carling, Robert W.,Street, Leslie J.,Hallett, David J.,Goodacre, Simon,Mezzogori, Elena,Reader, Michael,Cook, Susan M.,Bromidge, Frances A.,Newman, Robert,Smith, Alison J.,Wafford, Keith A.,Marshall, George R.,Reynolds, David S.,Dias, Rebecca,Ferris, Pushpindar,Stanley, Jo,Lincoln, Rachael,Tye, Spencer J.,Sheppard, Wayne F. A.,Sohal, Bindi,Pike, Andrew,Dominguez, Maria,Atack, John R.,Castro, José L.

, p. 1235 - 1238 (2007/10/03)

The identification of a series of imidazo[1,2-b][1,2,4]triazines with high affinity and functional selectivity for the GABAA α3-containing receptor subtype is described, leading to the identification of a clinical candidate, 11. Compound 11 shows good bioavailability and half-life in preclinical species, and it is a nonsedating anxiolytic in both rat and squirrel monkey behavioral models.

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disorders

Goodacre, Simon C.,Street, Leslie J.,Hallett, David J.,Crawforth, James M.,Kelly, Sarah,Owens, Andrew P.,Blackaby, Wesley P.,Lewis, Richard T.,Stanley, Joanna,Smith, Alison J.,Ferris, Pushpinder,Sohal, Bindi,Cook, Susan M.,Pike, Andrew,Brown, Nicola,Wafford, Keith A.,Marshall, George,Castro, José L.,Atack, John R.

, p. 35 - 38 (2007/10/03)

A series of high-affinity GABAA agonists with good oral bioavailability in rat and dog and functional selectivity for the GABA Aα2 and -α3 subtypes is reported. The 7-trifluoromethylimidazopyrimidine 14g and the 7-propan-2-olimidazopyrimidine 14k are anxiolytic in both conditioned and unconditioned animal models of anxiety with minimal sedation observed at full BZ binding site occupancy.

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

Goodacre, Simon C.,Hallett, David J.,Carling, Robert W.,Castro, Jose L.,Reynolds, David S.,Pike, Andrew,Wafford, Keith A.,Newman, Robert,Atack, John R.,Street, Leslie J.

, p. 1582 - 1585 (2007/10/03)

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones are high affinity GABAA agonists. Compound 16d has good oral bioavailability in rat, functional selectivity for the GABAAα2 and

The expedient synthesis of 4,2′-difluoro-5′-(7- trifluoromethylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile, a GABA α2/3 agonist

Cameron, Mark,Foster, Bruce S.,Lynch, Joseph E.,Shi, Yao-Jun,Dolling, Ulf-H.

, p. 398 - 402 (2012/12/22)

An expedient regioselective synthesis of a GABA α2/3 agonist 1 is described. The key step is an efficient regioselective palladium-catalyzed coupling of 7-trifluoromethylimidazo[1,2-a]pyrimidine (5) to 5′-chloro-4,2′-difluorobiphenyl-2-carbonitrile (15).

Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

Jennings, Andrew S.R.,Lewis, Richard T.,Russell, Michael G.N.,Hallett, David J.,Street, Leslie J.,Castro, Jose L.,Atack, John R.,Cook, Susan M.,Lincoln, Rachael,Stanley, Joanna,Smith, Alison J.,Reynolds, David S.,Sohal, Bindi,Pike, Andrew,Marshall, George R.,Wafford, Keith A.,Sheppard, Wayne F.A.,Tye, Spencer J.

, p. 1477 - 1480 (2007/10/03)

Imidazo[1,2-a]pyrimidines and imidazo[1,2-b][1,2,4]triazines are ligands for the benzodiazepine binding site of GABAA receptors that are functionally selective for the α2/α3 subtypes over the α1 subtype. SAR studies to optimise this functional

IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

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Page 45-46, (2010/02/04)

A class of 8-fluoro-3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a -NH- or -OCH2- linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

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