4282-34-2

Basic information

• Product Name: 2,5-Thiophenedicarboxylic acid dimethyl ester
• Synonyms: 2,5-Thiophenedicarboxylic acid dimethyl ester;2,5-diMethyl thiophene-2,5-dicarboxylate;diMethyl thiophene-2,5-dicarboxylate;2,5-Thiophenedicarboxylic acid, 2,5-dimethyl ester
• CAS NO: 4282-34-2
• Molecular Formula: C₈H₈O₄S
• Molecular Weight: 200.21172
• Mol File: 4282-34-2.mol

Chemical Properties

• Melting Point: 148.5-149.5 °C
• Boiling Point: 291.6 °C at 760 mmHg
• Flash Point: 130.2 °C
• Appearance: /
• Density: 1.294 g/cm³
• CAS DataBase Reference: 2,5-Thiophenedicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Thiophenedicarboxylic acid dimethyl ester(4282-34-2)
• EPA Substance Registry System: 2,5-Thiophenedicarboxylic acid dimethyl ester(4282-34-2)

Safety Data

• Hazardous Substances Data: 4282-34-2(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
2,5-Thiophenedicarboxylic acid dimethyl ester is used as a research compound for its unique chemical properties and reactions, making it valuable in various scientific studies.
Used in Chemical Synthesis:
This ester is employed as an intermediate or reactant in the synthesis of various chemical compounds, contributing to the development of new materials and products.
Used in Medical and Pharmaceutical Fields:
2,5-Thiophenedicarboxylic acid dimethyl ester is used as a pharmacological agent, with its properties being studied for potential therapeutic applications. Its toxicological profile is also crucial for understanding its safety and efficacy in medical use.

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 67-56-1 methanol 
• 3141-27-3 2,5-dibromothiophen 
• 201230-82-2 carbon monoxide 
• 188290-36-0 thiophene 
• 56-23-5 tetrachloromethane 

Downstream Products

• 50340-79-9 thiophene-2,5-dicarboxylic acid monomethyl ester 
• 858840-42-3 dimethyl 3-nitrothiophene-2,5-dicarboxylate 
• 6007-86-9 di-(hydroxymethyl)-2,5 thiophene 
• 709613-19-4 (R)-5-(1-Phenyl-ethylcarbamoyl)-thiophene-2-carboxylic Acid Methyl Ester 
• 709613-20-7 (S)-5-(1-p-Tolyl-ethylcarbamoyl)-thiophene-2-carboxylic Acid Methyl Ester 
• 133380-41-3 methyl 5-(chlorocarbonyl)thiophene-2-carboxylate 
• 1257585-18-4 C₁₈H₂₂N₂O₇S₂ 
• 1257585-19-5 C₁₇H₂₂N₄O₆S₂ 
• 1257585-22-0 C₂₁H₁₉N₃O₄S 
• 1257585-23-1 C₂₀H₁₉N₅O₃S 
• 1257585-26-4 C₂₀H₁₈N₂O₅S 
• 1257585-27-5 C₁₉H₁₈N₄O₄S 
• 1257585-30-0 C₂₀H₂₂N₂O₅S 
• 1257585-31-1 C₁₉H₂₂N₄O₄S 

Relevant articles and documents

Synthesis of 2-thiophenecarboxylic and 2,5-thiophenedicarboxylic acid esters via the reaction of thiophenes with the CCl4-ROH reagent in the presence of vanadium, iron, and molybdenum catalysts

2-Thiophenecarboxylic and 2,5-thiohenedicarboxylic acid esters were synthesized via the reaction of thiophene with the CCl4-ROH-catalyst system, with a total yield of 44-85%. A possible reaction scheme includes the successive steps of alkylation of thiophene with carbon tetrachloride, leading to 2-trichloromethylthiophene, and alcoholysis of the product giving the corresponding 2-thiophenecarboxylate. The best catalysts for this reaction are VO(acac)2, Fe(acac)3, and Mo(CO)6.

A New Indirect Application of Aggregative Activation: Synthesis of Esters by Cobalt-Catalyzed Carbonylation of Aryl, Heterocyclic, and Vinyl Halides under Atmospheric Pressure

Sun lamp illuminated alkoxycarbonylation of aryl, heteroaryl, and vinyl halides was performed under atmospheric pressure of CO in the presence of a cobalt catalyst in situ generated from Co(OAc)2.Illunination through a Pyrex flask was sufficient to catalyze the reaction.This process avoids the use of Co2(CO)8 and excess CH3I, which were required in the earlier procedure.A SRN1 mechanism is proposed.