50340-79-9

Basic information

• Product Name: 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
• Synonyms: 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
• CAS NO: 50340-79-9
• Molecular Formula: C₇H₆O₄S
• Molecular Weight: 186.18
• Mol File: 50340-79-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 187-190℃
• Boiling Point: 365.2°C at 760 mmHg
• Flash Point: 174.7°C
• Appearance: /
• Density: 1.439g/cm³
• Vapor Pressure: 5.62E-06mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.04±0.10(Predicted)
• CAS DataBase Reference: 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID(50340-79-9)
• EPA Substance Registry System: 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID(50340-79-9)

Safety Data

• Statements: 20/21/22
• Safety Statements: 3/9-24/25-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 50340-79-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H6O4S/c1-11-7(10)5-3-2-4(12-5)6(8)9/h2-3H,1H3,(H,8,9)

Upstream product

• 4282-34-2 Dimethyl thiophene-2,5-dicarboxylate 
• 67808-64-4 5-formyl-thiophene-2-carboxylic acid methyl ester 
• 4565-31-5 5-formyl-2-thiophencarboxylic acid 
• 58268-08-9 2-(2-thienyl)-1,3-dioxolane 
• 98-03-3 thiophene-2-carbaldehyde 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 124-38-9 carbon dioxide 
• 4282-31-9 Thiophene-2,5-dicarboxylic acid 
• 74-88-4 methyl iodide 
• 3737-38-0 5-propynyl-thiophene-2-carboxylic acid 
• 501-91-7 junipal 
• 116530-64-4 5-prop-1-ynyl-thiophene-2-carboxylic acid methyl ester 

Downstream Products

• 487002-91-5 4-{[(5-Hydroxycarbamoyl-thiophene-2-carbonyl)-amino]-methyl}-benzoic acid methyl ester 
• 67808-34-8 methyl 5-cyano-2-thiophenecarboxylate 
• 1616087-96-7 N-[5-methoxycarbonylthenoyl]-S-methyl-S-phenylsulfoximine 
• 927197-16-8 C₁₅H₁₅NO₄S 
• 871676-32-3 (R)-5-[1-(4-bromo-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester 
• 742070-17-3 methyl 5-(2-(tert-butoxycarbonylamino)phenylcarbamoyl)thiophene-2-carboxylate 
• 312761-00-5 5-(2-(S)-Benzyloxycarbonylamino-2-tert-butoxycarbonyl-ethylcarbamoyl)-thiophene-2-carboxylic acid methyl ester 
• 2495-15-0 N-(5-methoxycarbonyl-2-thenoyl)-N'-benzoylhydrazide 
• 133380-75-3 O-(2-methoxycarbonyl-5-thenoyl)benzamide oxime 
• 133380-49-1 methyl 5--2-thiophenecarboxylate 
• 133380-43-5 N-(5-methoxycarbonyl-2-thenoyl)-α-aminoacetophenone 
• 133380-51-5 methyl 5-(2-phenyloxazol-5-yl)-2-thiophenecarboxylate 
• 133380-45-7 methyl 5-(5-phenoxazol-2-yl)-2-thiophenecarboxylate 
• 133380-67-3 methyl 5-(3-phenyl-1,2,4-oxadiazol-5-yl)-2-thiophenecarboxylate 

Relevant articles and documents

Redox-Neutral Photocatalytic C?H Carboxylation of Arenes and Styrenes with CO2

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MONOCYCLIC, THIENO, PYRIDO, AND PYRROLO PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE OF THE SAME

The present invention provides monocyclic, thieno, pyrido and pyrrolo pyrimidine compounds. Pharmaceutical compositions comprising one or more of these compounds and optionally comprising a pharmaceutically acceptable salt or hydrate of one or more of the compounds are provided. Preferably, these pharmaceutical compositions further comprise at least one pharmaceutically acceptable carrier. Methods of treating a patient having cancer are provided wherein a therapeutically effective amount of one or more of these compounds or pharmaceutical compositions are administered to the patient.

Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F

A series of dipeptide nitriles with different P3 substituents was designed to explore the S3 binding pocket of cathepsin S. Racemic 7-16 and the enantiopure derivative (R)-22 proved to be potent inhibitors of human cathepsin S and exhibited notable selectivity over human cathepsins L, K, and B. Inhibition of cathepsin F, the functional synergist of cathepsin S, was not observed. The azadipeptide analogue of 22, compound 26, was highly potent but nonselective.