441717-40-4

Basic information

• Product Name: (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester
• Synonyms: (R)-1-Boc-pyrrolidine-1,3-dicarboxylate;(R)-1-BOC-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER;(R)-1-tert-Butoxycarbonyl-pyrrolidine-3-carboxylic acid methyl ester;(R)-Methyl 1-Boc-pyrrolid...;(R)-1-BOC-Pyrrolidine-3-carboxylic acid ethyl ester;(R)-Methyl 1-Boc-pyrrolidine-3-carboxylate;1-tert-butyl 3-Methyl (3R)-pyrrolidine-1,3-dicarboxylate;O1-tert-Butyl O3-methyl (3R)-pyrrolidine-1,3-dicarboxylate
• CAS NO: 441717-40-4
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.27
• EINECS: 1308068-626-2
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline
• Mol File: 441717-40-4.mol

Chemical Properties

• Boiling Point: 374.4°C at 760 mmHg
• Flash Point: 180.3°C
• Appearance: /
• Density: 1.301g/cm³
• Vapor Pressure: 1.23E-06mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester(441717-40-4)
• EPA Substance Registry System: (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester(441717-40-4)

Safety Data

• Hazardous Substances Data: 441717-40-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester is used as a chiral building block for the synthesis of complex organic molecules. The Boc protecting group allows for selective reactions, ensuring the production of enantiomerically pure products, which is crucial for the development of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester is used as an intermediate for the preparation of biologically active compounds. Its chiral nature and the presence of the Boc protecting group make it a valuable component in the synthesis of enantiomerically pure drugs, which can have significant implications for the efficacy and safety of medications.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester is utilized as a precursor for the synthesis of enantiomerically pure pesticides and other agrochemicals. The ability to selectively produce one enantiomer over another is important for enhancing the effectiveness and reducing the environmental impact of these compounds.
Overall, (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester is a versatile and valuable compound in the fields of organic synthesis, pharmaceuticals, and agrochemicals, owing to its unique structural features and applications in the synthesis of enantiomerically pure products.

InChI:InChI=1/C11H17NO6/c1-11(2,3)18-10(16)17-9(15)12-5-4-7(6-12)8(13)14/h7H,4-6H2,1-3H3,(H,13,14)/t7-/m1/s1

Upstream product

• 72925-16-7 (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 72925-16-7 1-boc-pyrrolidine-3-carboxylic acid 
• 192214-06-5 (R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid 
• 1217655-90-7 (R)-methyl-1-benzyloxycarbonyl-pyrrolidine-3-carboxylate 
• 99735-47-4 (3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine 
• 192214-05-4 benzyl (R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 198959-37-4 (R)-methyl pyrrolidine-3-carboxylate hydrochloric acid 

Downstream Products

• 1436862-03-1 trans-3-[N'-(6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carbonyl)-hydrazinocarbonyl]-(R)-pyrrolidin-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

A PROCESS FOR PREPARATION OF (2S, 5R)-7-OXO-6-SULPHOOXY-2-[((3R)-PYRROLIDINE-3-CARBONYL)-HYDRAZINO CARBONYL]-1,6-DIAZA-BICYCLO[3.2.1]OCTANE

A process for preparation of (2S, 5R)-7-oxo-6-sulphooxy-2- [((3R)-pyrrolidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza- bicyclo[3.2.1]octane is disclosed comprising reacting a compound of Formula (II) with a compound of Formula (III) to obtain a compound

FUSED HETEROCYCLIC COMPOUND

The present invention relates to a fused heterocyclic compound having the Formula 1, which is useful as a platelet aggregation inhibitor, a method for preparing the same, and a pharmaceutical composition for inhibiting platelet aggregation comprising the same.

Enzymatic resolution of n-substituted-β-prolines

A general and straightforward strategy for enzymatic resolution of N-substituted-β-proline has been successfully designed and developed in our research laboratories. A first affinity screen is followed by ratio enzyme/substrate optimization to source our

POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

PYRROLIDINE DERIVATIVES AS ERK INHIBITORS

Disclosed are the ERK inhibitors of Formula (1.0): and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (1.0).