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N-CARBOBENZOXY-DL-ASPARTIC ACID is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

4515-21-3

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4515-21-3 Usage

Chemical Properties

White solid

Check Digit Verification of cas no

The CAS Registry Mumber 4515-21-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,1 and 5 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4515-21:
(6*4)+(5*5)+(4*1)+(3*5)+(2*2)+(1*1)=73
73 % 10 = 3
So 4515-21-3 is a valid CAS Registry Number.

4515-21-3 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (C0631)  N-Carbobenzoxy-DL-aspartic Acid  >95.0%(T)

  • 4515-21-3

  • 1g

  • 150.00CNY

  • Detail
  • TCI America

  • (C0631)  N-Carbobenzoxy-DL-aspartic Acid  >95.0%(T)

  • 4515-21-3

  • 10g

  • 790.00CNY

  • Detail
  • Alfa Aesar

  • (H66950)  N-Benzyloxycarbonyl-DL-aspartic acid, 95%   

  • 4515-21-3

  • 5g

  • 251.0CNY

  • Detail
  • Alfa Aesar

  • (H66950)  N-Benzyloxycarbonyl-DL-aspartic acid, 95%   

  • 4515-21-3

  • 25g

  • 941.0CNY

  • Detail
  • Alfa Aesar

  • (H66950)  N-Benzyloxycarbonyl-DL-aspartic acid, 95%   

  • 4515-21-3

  • 100g

  • 3009.0CNY

  • Detail

4515-21-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(phenylmethoxycarbonylamino)butanedioic acid

1.2 Other means of identification

Product number -
Other names Cbz-DL-aspartic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4515-21-3 SDS

4515-21-3Relevant articles and documents

Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor

Sun, Weiguang,Wu, Yanli,Zheng, Mengzhu,Yang, Yueying,Liu, Yang,Wu, Canrong,Zhou, Yirong,Zhang, Yonghui,Chen, Lixia,Li, Hua

supporting information, p. 8146 - 8156 (2020/09/21)

Tumor necrosis factor α (TNF-α) is an important therapeutic target for rheumatoid arthritis, inflammatory bowel disease, and septic hepatitis. In this study, structure-based virtual ligand screening combined with in vitro and in vivo assays were applied.

Compound with TNF-alpha inhibition activity and application thereof

-

Paragraph 0006, (2020/07/13)

The invention provides a compound shown in a formula I, wherein substituent groups are defined in the specification. The provided compound is an effective TNF-alpha inhibitor, which can be used to treat autoimmune diseases.

Total synthesis of (-)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods

Eey, Stanley T.-C.,Lear, Martin J.

, p. 11556 - 11573 (2015/01/16)

(-)-Platensimycin is a potent inhibitor of fatty acid synthase that holds promise in the treatment of metabolic disorders (e.g., diabetes and "fatty liver") and pathogenic infections (e.g., those caused by drug-resistant bacteria). Herein, we describe its total synthesis through a four-step preparation of the aromatic amine fragment and an improved stereocontrolled assembly of the ketolide fragment, (-)-platensic acid. Key synthetic advances include 1) a modified Lieben haloform reaction to directly convert an aryl methyl ketone into its methyl ester within 30 seconds, 2) an experimentally improved dialkylation protocol to form platensic acid, 3) a sterically controlled chemo- and diastereoselective organocatalytic conjugate reduction of a spiro-cyclized cyclohexadienone by using the trifluoroacetic acid salt of α-amino di-tert-butyl malonate, 4) a tetrabutylammonium fluoride promoted spiro-alkylative para dearomatization of a free phenol to assemble the cagelike ketolide core with the moderate leaving-group ability of an early tosylate intermediate, and 5) a bismuth(III)-catalyzed Friedel-Crafts cyclization of a free lactol, with LiClO4 as an additive to liberate a more active oxocarbenium perchlorate species and suppress the Lewis basicity of the sulfonyloxy group. The longest linear sequence is 21 steps with an overall yield of 3.8% from commercially available eugenol. Relay tactics: The stereocontrolled assembly of the potent antibiotic (-)-platensimycin in 21 steps and 3.8% yield from eugenol is described (see scheme; TBAF: tetrabutylammonium fluoride; Ts: toluene-4-sulfonyl). Highlights are 1) a rapid oxidative esterification of an acyl aromatic, 2) a reliable dialkylation protocol to form platensic acid, 3) a π-facial conjugate reduction of a dienone, 4) a TBAF-promoted alkylative dearomatization of a free phenol, and 5) a Friedel-Crafts closure of a free lactol.

DNA Methyltransferase inhibitors

-

Page 15-16, (2008/06/13)

A compound of the formula or a pharmaceutically acceptable salt thereof,whereinR1, R2, and R3 are the same or different and are independently hydrogen, lower alkyl, aryl or substituted aryl, lower alkoxy, lower alkoxyalkyl, or cycloalkyl or cycloalkyl alkoxy, where each cycloalkyl group has from 3-7 members, where up to two of the cycloalkyl members are optionally hetero atoms selected from oxygen and nitrogen, and where any member of the alkyl, aryl or cycloalkyl group is optionally substituted with halogen, lower alkyl or lower alkoxy, aryl or substituted aryl, andwhereR3 can be ribose, deoxyribose or phosphorylated derivatives thereof,whereinR1, R2, and R3 are not all hydrogen andwhereinwhen R3 is ribose, deoxyribose or phosphorylated derivatives thereof, one of R1 or R2 is not hydrogen.

Syntheses of Polypeptides by Hidrogenolysis of N-Benzyloxycarbonyl-Amino Acid Anhydrides

Munegumi, Toratane,Meng, Yan-Quing,Harada, Kaoru

, p. 2748 - 2750 (2007/10/02)

When anhydrides of N-benzyloxycarbonyl-DL-aspartic acid (Z-DL-Asp), Z-L-Asp, N-Z-DL-glutamic acid (Z-DL-Glu), Z-L-Glu and N-Z-3-aminoglutaric acid (Z-β-Agl) were hydrogenolyzed in N,N-dimethylformamide (DMF), polypeptides were obtained in high yields.Hydrogenolyses of Z-DL-Glu and Z-L-Glu in dioxane gave pyroglutamic acid.

Composition containing a penem or carbapenem antibiotic

-

, (2008/06/13)

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. The composition may be prepared by simple mixing.

DIISOPROPYLETHYLAMINE ELIMINATES DIPEPTIDE FORMATION DURING THE ACYLATION OF AMINO ACIDS USING BENZOYL CHLORIDE AND SOME ALKYL CHLOROFORMATES

Chen, Francis M. F.,Benoiton, N. Leo

, p. 1224 - 1227 (2007/10/02)

Acylation of amino acids using benzoyl chloride in aqueous alkali leads to benzoylamino acids containing one percent of benzoyldipeptide.Use of diisopropylethylamine instead of sodium hydroxide as base eliminates the side reaction responsible for the contaminant.Ethoxycarbonylamino acids are advantageously prepared in the same manner using ethyl chloroformate or diethyl dicarbonate.The latter gives rise to some N-substituted dipeptide when used in aqueous alkali.The method is unsatisfactory for the benzyloxycarbonylation of amino acids.Use of 9-fluorenylmethyl chloroformate and diisopropylethylamine gives the pure derivative of leucine in moderate yield.

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