492-61-5Relevant articles and documents
Three novel quassinoids, javanicolides A and B, and javanicoside A, from seeds of Brucea javanica
Kim, Ik Hwi,Suzuki, Ryoko,Hitotsuyanagi, Yukio,Takeya, Koichi
, p. 9985 - 9989 (2003)
Two novel quassinoids, javanicolides A and B, and one novel quassinoid glucoside, javanicoside A were isolated from the seeds of Brucea javanica Merr. (Simaroubaceae), along with four known quassinoids, yadanziolides A and D, and bruceins D and E, and two known quassinoid glucosides, yadanziosides D and L. Their structures were elucidated by the analysis of spectral data and chemical evidence.
A new megastigmane glucoside and three new flavonoid glycosides from spiraea prunifolia var. simpliciflora
Yean, Min Hye,Kim, Ju Sun,Kang, Sam Sik,Kim, Yeong Shik
, p. 1123 - 1131 (2014)
A new megastigmane glucoside, simplicifloranoside (1), and three new flavonol glycosides, prunifolianosides A-C (2-4, resp.), were isolated from the aerial parts of Spiraea prunifolia var. simpliciflora. In addition, fifteen known compounds, including five phenolic acids, three lignans, four flavonoids, one eugenol glycoside, and two alkyl-primeverosides, were also identified. Their structures were elucidated on the basis of detailed spectroscopic analyses and acid hydrolysis. Copyright
Two new bufadienolides and one new pregnane from Helleborus thibetanus
Zhang, Hui,Su, Yanfang,Yang, Fengying,Zhao, Zeqing,Gao, Xiumei
, p. 164 - 167 (2014)
Two new bufadienolides, 3β,14β,16β-trihydroxy-5α-bufa-20,22-dienolide (1) and 14β-hydroxy-3β-[β-D-glucopyranosyl-(1→6)-(β-D-glucopyranosyl)oxy]-5α-bufa-20,22-dienolide (2), one new pregnane, 3β-hydroxypregna-5,16-diene-20-one-1β-yl sulfate (3), along with
Flavonoids from Malus hupehensis and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells
Wang, Shu-Qi,Zhu, Xiao-Feng,Wang, Xiao-Ning,Shen, Tao,Xiang, Feng,Lou, Hong-Xiang
, p. 119 - 125 (2013)
Three biflavonoid glycosides along with 12 known flavonoids, were isolated from leaves of Malus hupehensis. The complete structures of two of the compounds were established from analysis of MS, NMR spectroscopic and CD data, as well as DFT CD calculations they were determined to be atropisomeric along a central biaryl axis. The antioxidant activities and protective effects of the compounds against doxorubicin-induced cardiomyopathy in H9c2 cells were also investigated. Amongst all of the isolated compounds, quercetin was the most active radical scavenger with EC50 values of 3.2 μM and 17.8 μM by the DPPH and ABTS+ methods, respectively. The results indicated that three of the flavanoids also had a strong protective influence against doxorubicin-induced cell death with EC50 values of 8.3, 5.2 and 7.6 μM, respectively.
Alkenes with antioxidative activities from Murraya koenigii (L.) Spreng
Ma, Qin-Ge,Xu, Kun,Sang, Zhi-Pei,Wei, Rong-Rui,Liu, Wen-Min,Su, Ya-Lun,Yang, Jian-Bo,Wang, Ai-Guo,Ji, Teng-Fei,Li, Lu-Jun
, p. 799 - 803 (2016)
Four new alkenes (1-4), and six known alkenes (5-12) were isolated from Murraya koenigii (L.) Spreng. Their structures were elucidated on the basis of spectroscopic analyses and references. Compounds (1-12) were evaluated for antioxidative activities. Amo
Eremophilane derivatives from Senecio dianthus
Huang, Shuai,Zhou, Xian-Li,Wang, Hong-Yan,Wang, Cui-Juan,Zhou, Xiao-Li,Xiao, Feng,Weng, Jie
, p. 711 - 718 (2013)
From the aerial parts of Senecio dianthus, five eremophilane glucosides (1, 2, 4-6) and one new eremophilenolide (7) were isolated, together with sixteen known compounds (3, 8-22). Their structures and relative configurations were elucidated on the basis of extensive spectroscopic analysis, including HR-ESI-MS, X-ray, CD, 1D- and 2D-NMR experiments.
Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora
Shi, Yan-Hong,Zhu, Shu,Ge, Yue-Wei,He, Yu-Min,Kazuma, Kohei,Wang, Zhengtao,Yoshimatsu, Kayo,Komatsu, Katsuko
, p. 55 - 61 (2016)
The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4′-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed.
Cytisine-type alkaloids and flavonoids from the rhizomes of Sophora tonkinensis
Pan, Qi-Ming,Zhang, Gui-Jie,Huang, Ri-Zhen,Pan, Ying-Ming,Wang, Heng-Shan,Liang, Dong
, p. 429 - 435 (2016)
Abstract: A new cytisine-type alkaloid, (?)-N-hexanoylcytisine (1), and a new isoflavan, (3S, 4R)-4-hydroxy-7,4′-dimethoxyisoflavan 3′-O-β-d-glucopyranoside (2), along with 10 known compounds, were isolated from the rhizomes of Sophora tonkinensis. Their structures were determined by spectroscopic methods, chemical evidence, and ECD data analysis. All of the isolates were evaluated for their cytotoxic activities against four human tumor cell lines.
Two new glycosidal metabolites of endophytic fungus Penicillium sp. (NO.4) from Tapiscia sinensis
Wan, Qiao,Feng, Ziwei,Li, Xueshuang,Lv, Mengmeng,Guo, Zhiyong,Deng, Zhangshuang,Zou, Kun
, p. 283 - 286 (2016)
Two new glycosides, 8-O-β-D-glucopyranosyl-6-methyl-1-carboxylate methyl ester xanthone (1) and 4'-O-β-d-galactopyranosyl djalonensone (2), together with four known compounds, 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate methyl ester (3), cassionllin (4), djalonensone (5) and alternariol (6), were isolated from the endophytic fungus Penicillium sp. (NO.4) of Tapiscia sinensis Oliv. The structures of compounds 1-6 were elucidated by the analysis of 1D and 2D NMR and HRMS. The cytotoxic activities of these compounds were evaluated against four cancer cell lines, as well as antimicrobial activities against two plant-pathogenic microbes. Compounds 1-6 showed moderate cytotoxicity against the A549 cancer cell line with IC50values ranging from 6.8 to 35.8 μg mL-1and were found to be inactive against three other cancer cell lines MCF-7, Caski and Hep G-2.
Furofuran Lignan Glucosides with Estrogen-Inhibitory Properties from the Bangladeshi Medicinal Plant Terminalia citrina
Muhit, Md. Abdul,Umehara, Kaoru,Mori-Yasumoto, Kanami,Noguchi, Hiroshi
, p. 1298 - 1307 (2016)
Extracts from the leaves of the Bangladeshi medicinal plant Terminalia citrina were prepared, and 13 new furofuran lignan glucosides, terminalosides A-K (1-4, 6-12), 2-epiterminaloside D (5), and 6-epiterminaloside K (13), were characterized using various spectroscopic techniques. Twelve of the isolates were found to contain rare tetraoxygenated aryl groups in their structures. Analysis of the NMR chemical shifts for the oxymethine signals in the furofuran ring suggested a pragmatic approach to determining the relative configuration of these compounds. The ECD and NOESY spectroscopic data obtained allowed for the deduction of the absolute configurations and conformations of the compounds. The isolates were tested for their estrogenic/antiestrogenic activity using the MCF-7 and T47D estrogen-responsive human breast cancer cell lines. Terminalosides B (2) and G (8) exhibited inhibitory effects for both cell lines, and estradiol-enhanced cell proliferation was suppressed by 90% at concentrations lower than 10 M. Terminaloside E (6) showed inhibitory activity against the T47D cell line, whereas terminalosides C (3), F (7), and I (10) and 6-epiterminaloside K (13) displayed antiestrogenic activity against MCF-7 cells.
