492-61-5Relevant articles and documents
Three novel quassinoids, javanicolides A and B, and javanicoside A, from seeds of Brucea javanica
Kim, Ik Hwi,Suzuki, Ryoko,Hitotsuyanagi, Yukio,Takeya, Koichi
, p. 9985 - 9989 (2003)
Two novel quassinoids, javanicolides A and B, and one novel quassinoid glucoside, javanicoside A were isolated from the seeds of Brucea javanica Merr. (Simaroubaceae), along with four known quassinoids, yadanziolides A and D, and bruceins D and E, and two known quassinoid glucosides, yadanziosides D and L. Their structures were elucidated by the analysis of spectral data and chemical evidence.
Two new bufadienolides and one new pregnane from Helleborus thibetanus
Zhang, Hui,Su, Yanfang,Yang, Fengying,Zhao, Zeqing,Gao, Xiumei
, p. 164 - 167 (2014)
Two new bufadienolides, 3β,14β,16β-trihydroxy-5α-bufa-20,22-dienolide (1) and 14β-hydroxy-3β-[β-D-glucopyranosyl-(1→6)-(β-D-glucopyranosyl)oxy]-5α-bufa-20,22-dienolide (2), one new pregnane, 3β-hydroxypregna-5,16-diene-20-one-1β-yl sulfate (3), along with
Alkenes with antioxidative activities from Murraya koenigii (L.) Spreng
Ma, Qin-Ge,Xu, Kun,Sang, Zhi-Pei,Wei, Rong-Rui,Liu, Wen-Min,Su, Ya-Lun,Yang, Jian-Bo,Wang, Ai-Guo,Ji, Teng-Fei,Li, Lu-Jun
, p. 799 - 803 (2016)
Four new alkenes (1-4), and six known alkenes (5-12) were isolated from Murraya koenigii (L.) Spreng. Their structures were elucidated on the basis of spectroscopic analyses and references. Compounds (1-12) were evaluated for antioxidative activities. Amo
Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora
Shi, Yan-Hong,Zhu, Shu,Ge, Yue-Wei,He, Yu-Min,Kazuma, Kohei,Wang, Zhengtao,Yoshimatsu, Kayo,Komatsu, Katsuko
, p. 55 - 61 (2016)
The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4′-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed.
Two new glycosidal metabolites of endophytic fungus Penicillium sp. (NO.4) from Tapiscia sinensis
Wan, Qiao,Feng, Ziwei,Li, Xueshuang,Lv, Mengmeng,Guo, Zhiyong,Deng, Zhangshuang,Zou, Kun
, p. 283 - 286 (2016)
Two new glycosides, 8-O-β-D-glucopyranosyl-6-methyl-1-carboxylate methyl ester xanthone (1) and 4'-O-β-d-galactopyranosyl djalonensone (2), together with four known compounds, 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate methyl ester (3), cassionllin (4), djalonensone (5) and alternariol (6), were isolated from the endophytic fungus Penicillium sp. (NO.4) of Tapiscia sinensis Oliv. The structures of compounds 1-6 were elucidated by the analysis of 1D and 2D NMR and HRMS. The cytotoxic activities of these compounds were evaluated against four cancer cell lines, as well as antimicrobial activities against two plant-pathogenic microbes. Compounds 1-6 showed moderate cytotoxicity against the A549 cancer cell line with IC50values ranging from 6.8 to 35.8 μg mL-1and were found to be inactive against three other cancer cell lines MCF-7, Caski and Hep G-2.
Flavone tetraglycosides and benzyl alcohol glycosides from the Mongolian Medicinal plant dracocephalum ruyschiana
Selenge, Erdenechimeg,Murata, Toshihiro,Kobayashi, Kyoko,Batkhuu, Javzan,Fumihiko Yoshizaki
, p. 186 - 193 (2013)
From an extract of the aerial parts of Dracocephalum ruyschiana, five new flavone tetraglycosides, five new benzyl alcohol glycosides, and 19 known compounds were isolated. The tetraglycosides contain a 7-O-β-D- glucopyranosyl-(1→2)-β-D-glucopyranosyl-( 1→2)-[α-L- rhamnopyranosyl-(1→6)]-β-D-glucopyranosyl moiety. The benzyl alcohol glycosides had acyl groups on their glycosyl or aglycone moieties. The compounds were tested for antioxidant activity using DPPH. Although the new compounds were not active, phenylpropanoylquinic acid derivatives were revealed as radical scavengers in D. ruyschiana.
A C14-polyacetylenic glucoside with an α-pyrone moiety and four C10-polyacetylenic glucosides from Mediasia macrophylla
Kurimoto, Shin-ichiro,Okasaka, Mamoru,Kashiwada, Yoshiki,Kodzhimatov, Olimjon K.,Takaishi, Yoshihisa
, p. 688 - 692 (2010)
Polyacetylenic glucosides (1-5) were isolated from the MeOH extract of Mediasia macrophylla, and their structures were established by spectroscopic analyses. Compounds 2-4 were the first examples of C10-polyacetylenic glucosides found in the family Umbelliferae, while compound 1 was a unique polyacetylenic glucoside possessing an α-pyrone moiety.
Rapulasides A and B: Two novel intermolecular rearranged biiridoid glucosides from the roots of Heracleum rapula
Xiao, Weilie,Li, Shenghong,Niu, Xuemei,Zhao, Yu,Sun, Handong
, p. 5743 - 5746 (2005)
Two novel intermolecular rearranged biiridoid glucosides, rapulasides A and B (1 and 2), have been isolated from the roots of Heracleum rapula. Their structures were identified by extensive spectral analysis especially different NMR techniques. NOESY experiment, with the help of Dreiding molecular model, was used to elucidate their relative stereochemistry. Both compounds were tested for their inhibitory effects on rabbit platelet aggregation induced by PAF, ADP, or AA, respectively. Only trends of inhibition were observed for them.
Cytotoxic phenylpropanoid glycosides from Cirsium japonicum
Shang, Dong-Li,Ma, Qin-Ge,Wei, Rong-Rui
, p. 1122 - 1130 (2016)
Three new phenylpropanoid glycosides 1–3, along with nine known phenylpropanoid glycosides 4–12, were isolated from the aerial parts of Cirsium japonicum. The structures of isolated compounds were elucidated by chemical and spectroscopic methods. Compounds 1, 3, 6, 8, and 11 showed moderate cytotoxicities against MCF-7, U87, HCT116, and A549 cell lines with IC50values in the range of 1.35–11.32?μM. The known compounds 4–12 were obtained from this plant for the first time.
Isolation, identification and bioactivities of abietane diterpenoids from: Premna szemaoensis
Pu, De-Bing,Wang, Ting,Zhang, Xing-Jie,Gao, Jun-Bo,Zhang, Rui-Han,Li, Xiao-Nian,Wang, Yong-Mei,Li, Xiao-Li,Wang, He-Yao,Xiao, Wei-Lie
, p. 6425 - 6435 (2018)
Investigation of the leaves and stems of Premna szemaoensis resulted in the isolation of twelve new abietane diterpenoids, szemaoenoids A-L (1-12), together with four known abietane diterpenoids (13-16). The structures involved two rearranged-abietane skeletons: 17(15 → 16)-abeo-abietane (7, 10-12, 14 and 15) and 17(15 → 16),18(4 → 3)-diabeo-abietane (1-6, 13 and 16). The structures of the new compounds were established mainly by analyzing NMR and HRESIMS data. The absolute configurations of 1, 3 and 10 were confirmed by single crystal X-ray diffraction analysis. In bioactivity assays, compounds 11, 12, 14 and 15 were active against two human colon cancer cell lines (HCT-116 and HT-29) with IC50 values ranging from 8.8 to 34.3 μM, and compounds 10, 13 and 14 exhibited effective free radical scavenging activity with IC50 values ranging from 35.6 to 41.5 μM by DPPH experiment.
A novel hexanordammarane glycoside from the leaves and stems of Panax quinquefolium L.
Liu, Jin-Ping,Lu, Dan,Li, Ping-Ya
, p. 744 - 748 (2012)
One novel hexanordammarane glycoside, ginsenoside R10, was isolated from the leaves and stems of Panax quinquefolium L. as a minor constituent. It is the first time that a hexanordammarane glycoside isolated from the plant of Panax quinquefolium L. Its structure was elucidated as 3-O-β-D-glucopyranosyl-3β, 12β-dihydroxy-22, 23, 24, 25, 26, 27-hexanordammarane-20-one (1), by the combination analysis of one-dimensional NMR, two-dimensional NMR and mass spectrometry.
Flavonoids from silkworm droppings and their promotional activities on heme oxygenase-1
Park, Ji-Hae,Lee, Dae-Young,Yun, Pyeong,Yeon, Seung-Woo,Ko, Jong Hee,Kim, Yong-Soon,Baek, Nam-In
, p. 377 - 382 (2011)
A new flavane glucoside, 7,2'-dihydroxy-8-hydroxyethyl-4'-methoxyflavane- 2'-O-β-d-glucopyranoside (3), along with three known flavonoids, 7,2'-dihydroxy-8-prenyl-4'-methoxyflavane (1), euchrenone a7 (2), and 7,2'-dihydroxy-8-prenyl-4'-methoxy-2'-O-β-d-glucopyranosylflavane (4), was isolated from silkworm droppings. The structures of the compounds were elucidated on the basis of 1D and 2D NMR spectroscopic analyses and optical rotational characteristics. The compounds isolated from silkworm droppings were evaluated for their effects on heme oxygenase-1 (HO-1) activity. Compounds 1 and 3 increased the expression of HO-1 in HepG2 cells. HO-1 is an antioxidant enzyme that catabolizes heme to carbon monoxide, free iron, and biliverdin, all of which are involved in the suppression of inflammatory mediators.
Osteosaponins 1 and 2: Two new saponin glycosides from Osteospermum vaillantii
Ahmed, Bahar,Khan, Riaz A.,Al-Howiriny, Tawfeq A.,Al-Rehaily, Adnan J.
, p. 1258 - 1267 (2010)
Osteospermum vaillantii (Decne) T. Norl., collected from southern Saudi Arabia, yielded two new saponins characterised as 3-O-β-D-glucopyranosyl- (2′ → 1″)-β D-glucopyranosyl-(3′ → 1?)-O-β D-galactopyranosyl-oleanolic acid, designated as osteosaponin (1),
Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata
Yang, Jian-Hong,Kondratyuk, Tamara P.,Marler, Laura E.,Qiu, Xi,Choi, Yongsoo,Cao, Hongmei,Yu, Rui,Sturdy, Megan,Pegan, Scott,Liu, Ying,Wang, Li-Qin,Mesecar, Andrew D.,Breemen, Richard B. Van,Pezzuto, John M.,Fong, Harry H.S.,Chen, Ye-Gao,Zhang, Hong-Jie
, p. 641 - 647 (2010)
Kaempferol glycosides, named palmatosides A (1), B (2) and C (3), together with three known kaempferol glycosides, multiflorins A (4) and B (5), and afzelin (6), were isolated from the roots of the fern Neocheiropteris palmatopedata. Palmatosides A (1) and B (2) each possessed an unusual sugar moiety containing a 4,4-dimethyl-3-oxo-butoxy substituent group. The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit tumor necrosis factor alpha (TNF-α)-induced NF-κB activity, nitric oxide (NO) production, aromatase, quinone reductase 2 (QR2) and COX-1/-2 activities. Palmatosides B (2) and C (3) inhibited TNF-α-induced NF-κB activity with IC50 values of 15.7 and 24.1 μM, respectively; multiflorin A (4) inhibited aromatase enzyme with an IC50 value of 15.5 μM; afzelin (6) showed 68.3% inhibition against QR2 at a concentration of 11.5 μg/ml; palmatoside A (1) showed 52% inhibition against COX-1 enzyme at a concentration of 10 μg/ml; and multiflorin B (5) showed 52% inhibition against nitric oxide production at a concentration of 20 μg/ml. In addition, compounds 3-6 were shown to bind QR2 enzyme using LC-MS ultrafiltration binding assay.
Microchip Device for Performing Enzyme Assays
Hadd, Andrew G.,Raymond, Daniel E.,Halliwell, John W.,Jacobson, Stephen C.,Ramsey, J. Michael
, p. 3407 - 3412 (1997)
An automated enzyme assay was performed within a microfabricated channel network. Precise concentrations of substrate, enzyme, and inhibitor were mixed in nanoliter volumes using electrokinetic flow. Reagent dilution and mixing were controlled by regulating the applied potential at me terminus of each channel, using voltages derived from an equivalent circuit model of the microchip. The enzyme β-galactosidase (β-Gal) was assayed using resorufin β-D-galactopyranoside (RBG), a substrate that is hydrolyzed to resorufin, a fluorescent product Reaction kinetics were obtained by varying the concentration of substrate on-chip and monitoring the production of resorufin using laser-induced fluorescence. Derived Michaelis-Menten constants compared well between an on-chip and a conventional enzyme assay. Bias in the derived Km and kcat was primarily due to the limited solubility of RBG and the associated lack of measurements at substrate concentrations exceeding the Km. A Ki of 8 μM for the inhibitor phenylethyl β-D-thiogalactoside (PETG) was determined from plots of initial rate versus substrate concentration obtained at three concentrations of PETG. The relative inhibition of β-Gal by lactose, p-hydroxymercuribenzoic acid, and PETG was determined by varying the inhibitor concentration with constant enzyme and substrate concentration. An enzyme assay performed on the microchip within a 20-min period required only 120 pg of enzyme and 7.5 ng of substrate, reducing the amount of reagent consumed by 4 orders of magnitude over a conventional assay.
New monoterpenoids from the stigmas of Crocus sativus
Fang, Qing-Wei,Fu, Wen-Wei,Yang, Jin-Ling,Lu, Yue,Chen, Jiang-Cheng,Wu, Pei-Ying,Zhang, Xue,Xu, Hong-Xi
, p. 102 - 109 (2022)
One new compound, crocusatin M (1), and three new glycosidic compounds, crocusatins N-P (2–4), along with nine known compounds were isolated from the dried stigmas of Crocus sativus. The structures of new compounds were elucidated on the basis of spectros
Two New Triterpenoid Glycosides from the Roots of Rosa cymosa Tratt.
Ma, Guo-Xu,Huang, Xiao-Yan,Dai, Hua-Nian,Zhong, Xiao-Qing,Zhou, Yan-Lin,Su, Zuo-Lin,He, Ying-Zi,Yang, Jun-Shan,Yuan, Jing-Quan,Xu, Xu-Dong
, p. 482 - 486 (2016)
Two new triterpenoid glycosides, 3α,19α,23α-trihydroxy-2-oxo-12-ursen-28-O-β-d-glucopyranoside (1) and 3α,19α,23α-trihydroxy-2-oxoolean-12-en-28-O-β-d-glucopyranoside (2) as well as three known compounds, 2α,3α,19α-trihydroxyolean-12-en-28-O-β-d-glucopyranoside (3), 2α,3α,19α,23-tetrahydroxy-12-ursen-28-O-β-d-glucopyranoside (4), and 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid (5) were isolated from 75% EtOH extract of Rosa cymosa. Their structures were elucidated by extensive spectroscopic methods. All the isolated compounds displayed moderate inhibitory activity against LPS-induced NO production in macrophages.
Anti-inflammatory constituents from Psychotria prainii H. Lév
Tran, Phi Hung,Le, Viet Dung,Do, Thi Ha,Nguyen, Thi Luyen,Nguyen, Phuong Thao,Nguyen, Trong Thong,Nguyen, Tien Dat
, p. 695 - 700 (2019)
One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 2 and 4 exhibited strong effect with the IC50 values of 5.75?±?0.85 and 6.92?±?0.43?μM, respectively. This is the first report for the chemical composition and biological activity of P. prainii.
Antibacterial and cytotoxic phenolic metabolites from the fruits of amorpha fruticosa
Muharini, Rini,Diaz, Adriana,Ebrahim, Weaam,Mándi, Attila,Kurtán, Tibor,Rehberg, Nidja,Kalscheuer, Rainer,Hartmann, Rudolf,Orfali, Raha S.,Lin, Wenhan,Liu, Zhen,Proksch, Peter
, p. 169 - 180 (2017)
Fourteen new natural products, namely, 2-[(Z)- styryl]-5-geranylresorcin-1-carboxylic acid (1), amorfrutin D (2), 4-O-demethylamorfrutin D (3), 8-geranyl-3,5,7- trihydroxyflavanone (4), 8-geranyl-5,7,3′-trihydroxy-4′-methoxyisoflavone (5), 6-geranyl-5,7,3
Steric course of the hydrolysis of alpha,alpha-trehalose and alpha-D-glucosyl fluoride catalyzed by pig kidney trehalase.
Nakano,Brewer,Kasumi,Hehre
, p. 139 - 144 (1989)
We are unable to confirm the report of Labat et al.3 that pig kidney trehalase hydrolyzes alpha,alpha-trehalose to form solely alpha-D-glucose. Highly purified trehalase from pig renal cortex was found, in reactions monitored by 1H-n.m.r. spectra, to hydrolyze alpha,alpha-trehalose with the formation of both alpha- and beta-D-glucose. That the beta anomer constitutes the enzymically mobilized glucosyl residue is indicated by the further finding that beta-D-glucose is the product formed on hydrolysis of alpha-D-glucosyl fluoride by the enzyme. Present results show the stereochemical behavior of pig kidney trehalase in hydrolyzing alpha,alpha-trehalose to be indistinguishable from that reported by ourselves and others for trehalase preparations from a range of biological sources including rabbit renal cortex.
A new alkylene dihydrofuran glycoside with antioxidation activity from the root bark of Morus alba L
Fu, Wei,Lei, Yong Fang,Cai, Ya Ling,Zhou, Dao Nian,Ruan, Jin Lan
, p. 821 - 823 (2010)
A new alkylene dihydrofuran glycoside (1) was isolated from the root bark of Morus alba L., along with moracin M-3′-O-β-Dglucopyranoside (2), and moracin M-6, 3′-di-O-β-D-glucopyranoside (3). Compound 1 was identified as 2-methylene-3-methoxy-2, 5-dihydrofuran-4-O-β-D- glucopyranoside on the basis of chemical and spectroscopic data including 1D and 2D NMR spectral analysis. In addition, the antioxidant activity of 1 was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay. The IC50 values were 2.49 and 0.45 mg/mL, respectively.
IMMOBILIZED ENZYME KINETIC STUDY OF D-GLUCOSE MUTAROTATION BY FLOW INJECTION ANALYSIS.
Stults,Wade,Crouch
, p. 2245 - 2247 (1987)
A novel analytical application of immobilized enzymes is presented in which the mutarotation kinetics of D-glucose are studied. A glucose oxidase single bead string reactor is combined with the Trinder reaction in a flow injection system. The apparatus is used to monitor the mutarotation of D-glucose in a batch reactor. The mutarotation coefficients obtained are in good agreement with the literature values. Phosphate ion is shown to catalyze the reaction and the mutarotation coefficient is directly proportional to its concentration. The selectivity of the enzyme reactor is also demonstrated.
A new 2-(2-phenylethyl)chromone glycoside in Chinese agarwood “Qi-Nan” from Aquilaria sinensis
Shao, Hang,Mei, Wen-Li,Kong, Fan-Dong,Dong, Wen-Hua,Li, Wei,Zhu, Guo-Peng,Dai, Hao-Fu
, p. 42 - 46 (2017)
A new 2-(2-phenylethyl)chromone glycoside, 2-[2-(4-glucosyloxy-3-methoxyphenyl)ethyl]chromone (1), was isolated from the high-quality Chinese agarwood “Qi-Nan” originating from Aquilaria sinensis (Lour.) Glig. The structure including the absolute configuration of the sugar moiety was elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR), MS analysis, PMP-labeling HPLC analysis methods, as well as comparison with literature data. To the best of our knowledge, it is the first time that chromone glycoside was discovered in agarwood, or even in the whole Aquilaria plants.
Chemical constituents from the fruit of Gardenia jasminoides and their inhibitory effects on nitric oxide production
Peng, Kaifeng,Yang, Liguo,Zhao, Shizhe,Chen, Lixia,Zhao, Feng,Qiu, Feng
, p. 1127 - 1131 (2013)
Three new iridoid glycosides, 6″-O-trans-caffeoylgenipin gentiobioside (1), genipin 1-O-β-d-apiofuranosyl (1→6)-β-d- glucopyranoside (2), genipin 1-O-α-d-xylopyranosyl (1→6)-β-d- glucopyranoside (3), three new monocyclic monoterpenoids, jasminoside R (4),
A new cerebroside from the entomopathogenic fungus Ophiocordyceps longiissima: Structural-electronic and antioxidant relations. Experimental and DFT calculated studies
Elshamy, Abdelsamed I.,Yoneyama, Tatsuro,Trang, Nguyen Van,Son, Ninh The,Okamoto, Yasuko,Ban, Sayaka,Noji, Masaaki,Umeyama, Akemi
, (2020)
The chemical characterization of n-butanol soluble extract of the fungus Ophiocordyceps longiissima NBRC 106965 afforded a new cerebroside, 1-O-(β-d-glucopyranosyl)-(2S,3R,4E,8E)-2-[(2′R)-2′-hydroxyheptadecanoylamino]-9-methylheptadeca-4,8-diene-1,3-diol, trivially named ophiocordylongiiside A (1), in addition to 22E,24R-24-methylcholest-5,22-diene-3-O-β-D-O-glucopyranoside (2). The chemical structure of 1 was established based upon the by modern spectroscopic and chemical techniques. Compound 1 exhibited strong DPPH-free radical scavenging with the IC50 value of 55.72 mg/mL. The biological result can be explained by density functional theoretical (DFT) calculation, in which antioxidant activity is mostly controlled by the O–H bond dissociation enthalpy (BDE) following hydrogen atom transfer (HAT) mechanism. In all studied environments, the lowest BDE values are found in 2′-OH.
Exopolysaccharide Produced by Probiotic Bacillus albus DM-15 Isolated From Ayurvedic Fermented Dasamoolarishta: Characterization, Antioxidant, and Anticancer Activities
Kalimuthu, Palanisamy,Ma, Yongkun,Mathivanan, Krishnamurthy,Rai, Amit Kumar,Saravanan, Kandasamy,Sathiyanarayanan, Ganesan,Sekar, Soundarapandian,Sudharsan, Kumaresan,Vinothkanna, Annadurai
, (2022/03/31)
An exopolysaccharide (EPS) was purified from the probiotic bacterium Bacillus albus DM-15, isolated from the Indian Ayurvedic traditional medicine Dasamoolarishta. Gas chromatography-mass spectrophotometry and nuclear magnetic resonance (NMR) analyses revealed the heteropolymeric nature of the purified EPS with monosaccharide units of glucose, galactose, xylose, and rhamnose. Size-exclusion chromatography had shown the molecular weight of the purified EPS as around 240 kDa. X-ray powder diffraction analysis confirmed the non-crystalline amorphous nature of the EPS. Furthermore, the purified EPS showed the maximum flocculation activity (72.80%) with kaolin clay and emulsification activity (67.04%) with xylene. In addition, the EPS exhibits significant antioxidant activities on DPPH (58.17 ± 0.054%), ABTS (70.47 ± 0.854%) and nitric oxide (58.92 ± 0.744%) radicals in a concentration-dependent way. Moreover, the EPS showed promising cytotoxic activity (20 ± 0.97 μg mL–1) against the lung carcinoma cells (A549), and subsequent cellular staining revealed apoptotic necrotic characters in damaged A549 cells. The EPS purified from the probiotic strain B. albus DM-15 can be further studied and exploited as a potential carbohydrate polymer in food, cosmetic, pharmaceutical, and biomedical applications.
The identification of phenylpropanoids isolated from the root bark of Ailanthus altissima (Mill.) Swingle
Du, Ye-Qing,Yan, Zhi-Yang,Chen, Jing-Jie,Wang, Xiao-Bo,Huang, Xiao-Xiao,Song, Shao-Jiang
, p. 1139 - 1146 (2019/08/08)
Chemical investigation of 75% EtOH exact of the root bark of Ailanthus altissima (Mill.) Swingle led to the isolation and identification of two new phenylpropanoids (1–2), along with six known compounds (3–8). Their chemical structures were elucidated by extensive spectroscopic data analyses including NMR experiments and HRESIMS analyses, as well as computer-assisted structure elucidation software (ACD/Spectrus Processor). All compounds were evaluated for cytotoxic activities against Hep 3B and Hep G2 cells. Compound 1 and 7 displayed weak cytotoxic activities against the Hep 3B cell line.
