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4972-40-1

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4972-40-1 Usage

Description

Diethyl (piperidin-1-ylmethyl)phosphonate, also known as EA-2192, is an organophosphorus compound that exists as a white crystalline solid. It is primarily utilized as an intermediate in the synthesis of pharmaceuticals, pesticides, and other organic compounds. diethyl (piperidin-1-ylmethyl)phosphonate is recognized for its capacity to inhibit the enzyme acetylcholinesterase, which is pivotal in the regulation of nerve signal transmission.

Uses

Used in Pharmaceutical Industry:
Diethyl (piperidin-1-ylmethyl)phosphonate is used as an intermediate in the synthesis of various pharmaceuticals for its ability to inhibit acetylcholinesterase, potentially aiding in the development of treatments for neurological disorders such as Alzheimer's disease.
Used in Pesticide Industry:
In the agricultural sector, diethyl (piperidin-1-ylmethyl)phosphonate is used as an active ingredient in pesticides, leveraging its acetylcholinesterase-inhibiting properties to control pests by disrupting their nervous systems.
Used in Organic Chemistry Research:
Diethyl (piperidin-1-ylmethyl)phosphonate serves as a valuable intermediate in organic chemistry for the synthesis of a range of organic compounds, contributing to the advancement of chemical research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 4972-40-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,7 and 2 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4972-40:
(6*4)+(5*9)+(4*7)+(3*2)+(2*4)+(1*0)=111
111 % 10 = 1
So 4972-40-1 is a valid CAS Registry Number.

4972-40-1Downstream Products

4972-40-1Relevant articles and documents

Catalyst-Free and Selective C-N Bond Functionalization: Stereospecific Three-Component Coupling of Amines, Dichloromethane, and >P(O)H Species Affording α-Aminophosphorus Compounds

Zhao, Yalei,Chen, Xiuling,Chen, Tieqiao,Zhou, Yongbo,Yin, Shuang-Feng,Han, Li-Biao

, p. 62 - 69 (2015/09/01)

Catalyst-free and selective C-N bond functionalization has been achieved through three-component coupling of amines, dihalomethane, and >P(O)H species. This reaction takes place stereospecifically with retention of configuration at phosphorus, which can produce various new optically active phosphorus analogues of α-amino acids.

Synthesis and acid-base properties of α-aminophosphoryl compounds

Zakharov,Nuriazdanova,Garifzyanov,Galkin,Cherkasov

, p. 873 - 881 (2007/10/03)

α-Aminophosphoryl compounds of the phosphonate, phosphine oxide, and α,ω-bis(phosphine oxide) series and some of their thiophosphoryl analogs were synthesized. Potentiometric measurements of the pKa of the conjugate acids revealed an insignificant effect of variation of substituents on the phosphorus, nitrogen, and α-carbon atoms on the basicity of the phosphorylated amines. The latter are weak bases. Organophosphorus groups decrease the basicity of the amines by almost 5 pK a units. The role of the hydrophobic effect and intramolecular H-bonding in the obtained substances was discussed.

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