503176-36-1

Basic information

• Product Name: 2-Propynal, 3-(3-pyridinyl)- (9CI)
• Synonyms: 2-Propynal, 3-(3-pyridinyl)- (9CI)
• CAS NO: 503176-36-1
• Molecular Formula: C8H5NO
• Molecular Weight: 131.1314
• Product Categories: PYRIDINE
• Mol File: 503176-36-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propynal, 3-(3-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propynal, 3-(3-pyridinyl)- (9CI)(503176-36-1)
• EPA Substance Registry System: 2-Propynal, 3-(3-pyridinyl)- (9CI)(503176-36-1)

Safety Data

• Hazardous Substances Data: 503176-36-1(Hazardous Substances Data)

Upstream product

• 1313-13-9 manganese(IV) oxide 
• 61266-33-9 1-(pyridin-3-yl)-1-propyn-3-ol 
• 1120-90-7 3-iodopyridine 
• 626-55-1 3-Bromopyridine 
• 2510-23-8 3-Ethynylpyridine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1591623-44-7 C₁₄H₁₁N₃ 

Relevant articles and documents

Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde

A transition-metal-free, facile and efficient method for the synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde with moderate to good yields has been developed. The direct transformation process and good tolerance of various substituents make it an alternative approach to previous protocols, and potential applications of these investigated compounds are expected with or without post-modifications.

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Convenient synthesis of arylpropargyl aldehydes and 4-aryl-3-butyn-2-ones from arylacetylenes and amide acetals

The reaction of arylacetylenes 1 and N,N-dimethylformamide dimethylacetal (2a, DMF-DMA) afforded the corresponding arylpropargyl aldehydes 3 in moderate yields. Similarly, the reaction of 1 and N,N-dimethylacetamide dimethylacetal (2b, DMA-DMA) gave 4-aryl-3-butyn-2-ones 4.