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5369-03-9

N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE, also known as QX 314 chloride, is a membrane-impermeant lidocaine derivative with significant applications in the field of neuroscience and pharmaceuticals. It selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, making it a valuable tool for studying and managing pain.

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  • 5369-03-9 Structure

  • Basic information

    1. Product Name: N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE
    2. Synonyms: QX 314 CHLORIDE;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;Lidocaine N-ethyl chloride;N-Ethyllidocaine chloride;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride;QX314.Cl
    3. CAS NO:5369-03-9
    4. Molecular Formula: C16H27ClN2O
    5. Molecular Weight: 298.85
    6. EINECS: N/A
    7. Product Categories: Ion Channels
    8. Mol File: 5369-03-9.mol

  • Chemical Properties

    1. Melting Point: 209-211 °C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Room temp
    8. Solubility: insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O
    9. CAS DataBase Reference: N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE(5369-03-9)
    11. EPA Substance Registry System: N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE(5369-03-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 5369-03-9(Hazardous Substances Data)

5369-03-9 Usage

Uses

Used in Neuroscience Research:
N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE is used as a research tool for studying the function and behavior of nociceptive neurons. Its ability to selectively block sodium channels when delivered intracellularly via the TRPV1 channel allows researchers to gain insights into the mechanisms of pain perception and transmission.
Used in Pain Management:
N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE is used as a potential therapeutic agent for managing pain. By blocking sodium channels on nociceptive neurons, it can elicit a long-lasting decrease in the response to painful mechanical and thermal stimuli without causing the motor deficits associated with many conventional local anesthetics.
Used in Local Anesthesia:
In the field of anesthesiology, N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE is used as a local anesthetic agent. At concentrations ranging from 10-70 mM, it produces robust local anesthesia with a slow onset in various animal models, such as the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.
Used in Antitussive Applications:
N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE has been shown to have antitussive properties in mammalian animal models, making it a potential therapeutic agent for the treatment of cough and related respiratory conditions.

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.

Biochem/physiol Actions

Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.

Check Digit Verification of cas no

The CAS Registry Mumber 5369-03-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,6 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5369-03:
(6*5)+(5*3)+(4*6)+(3*9)+(2*0)+(1*3)=99
99 % 10 = 9
So 5369-03-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

5369-03-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium,chloride

1.2 Other means of identification

Product number -
Other names Lidocaine N-ethyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5369-03-9 SDS

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