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Factory Supply Bulk High Quality Lidocaine cas 137-58-6
Cas No: 137-58-6
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137-58-6 Usage




ChEBI: The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Brand name

Alphacaine (Carlisle); Lidoderm (Teikoku); Xylocaine (AstraZeneca).

Contact allergens

Lidocaine is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.


Lidocaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. The fat soluble and protein binding rate of lidocaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
Lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.
Lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.


Antiarrhythmic Agents, Anesthetics


Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions. Lidocaine (Alphacaine)is a second-generation antihistamine agent closely st

Biological Activity

Anasthetic and class Ib antiarrhythmic agent.? Blocks voltage-gated sodium channels in the inactivated state.

Chemical property

Lidocaine is white needle like crystals, and its melting point is 68-69℃; boiling point is 180-182℃ (0.53kPa), soluble in ethanol in 159-160℃ (0.267kPa), ether, benzene, chloroform and oil, do not dissolve in water. In common use radical hydrochloride, lidocaine hydrochloride (C14H22N2O • HCL, [73-78-9]) is a white crystalline powder. Melting point 127-129℃, and the monohydrate melting point is 77-78℃. Easily soluble in water, 0.5% aqueous solution pHO 4.0-5.5. Odorless, bitter taste.


1, This product is a local anesthetics of amide derivatives,and widely used in surface anesthesia, anesthesia, conduction anesthesia and epidural anesthesia. The LD50 of oral lidocaine hydrochloride to mice was 290 mg/kg.
2, Used as a local anesthetic.

Chemical Properties




137-58-6 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (L0156)  Lidocaine  >99.0%(HPLC)(T) 137-58-6 500g 2,990.00CNY Detail
TCI America (L0156)  Lidocaine  >99.0%(HPLC)(T) 137-58-6 100g 990.00CNY Detail
TCI America (L0156)  Lidocaine  >99.0%(HPLC)(T) 137-58-6 25g 380.00CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name lidocaine

1.2 Other means of identification

Product number -
Other names L-Caine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137-58-6 SDS

137-58-6Related news

The comparison of midazolam and topical Lidocaine (cas 137-58-6) spray versus the combination of midazolam, meperidine, and topical Lidocaine (cas 137-58-6) spray to sedate patients for upper endoscopy09/30/2019

Background: Whether an opiate-benzodiazepine combination is superior to benzodiazepine alone for sedation in upper endoscopy is controversial. The purpose of this study was to compare the effectiveness of intravenous midazolam alone versus the combination of intravenous midazolam and intravenous...detailed

Comparison of Cutaneous Anesthetic Effect of 8% Lidocaine (cas 137-58-6) Spray with Lidocaine (cas 137-58-6) Patch Using Current Perception Threshold Test09/29/2019

Objective.  A lidocaine patch is often used for topical anesthesia prior to venipuncture, but needs to be applied for several hours before the puncture, and the site is fixed. A metered‐dose lidocaine pump spray could be used to produce cutaneous topical anesthesia. In this study, we compared t...detailed

A Study of Promethazine Hydrochloride and Pentazocine Intramuscular Sedation Along with 2 % Lidocaine (cas 137-58-6) Hydrochloride and Adrenaline and Comparison to Placebo Along with 2 % Lidocaine (cas 137-58-6) Hydrochloride and Adrenaline for Surgical Extraction of Mandibular Third Molar10/01/2019

Background and Objectives The main objective is to study and compare the sedative and analgesic effects of intramuscular injection fortwin–phenergan along with local anesthetic and normal saline placebo along with local anesthetics in mandibular third molar surgery. We also assessed and com...detailed

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