5411-48-3Relevant articles and documents
Routes to N-vinyl-nitroimidazoles and N-vinyl-deazapurines
Clayton, Russell,Ramsden, Christopher A.
, p. 701 - 705 (2007/10/03)
The preparations of 4- and 5-nitro-1-vinylimidazole (2 and 7) are described. Selective reduction of the nitro group using Fe/dil HCl is achieved for the 4-nitro derivative but this is not effective when ethoxymethylenemalononitrile is used to trap the amine. For 5-nitroimidazole studies the N-vinyl substituent is kept masked as a 2-chloroethyl group, which remains unchanged during catalytic reduction of the nitro function (Pd/C), and is revealed by HCl elimination at a later stage. In this way, the 1-deazapurine 13 and the tricyclic derivative 14 have been prepared.