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54518-92-2

L-LEUCINE CHLOROMETHYL KETONE HYDROCHLORIDE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 54518-92-2 Structure

  • Basic information

    1. Product Name: L-LEUCINE CHLOROMETHYL KETONE HYDROCHLORIDE
    2. Synonyms: H-Leu-CMK.HClL-Leucine chloroMethyl ketone hydr;(S)-3-AMino-1-chloro-5-Methylhexan-2-one hydrochloride;2-Hexanone,3-aMino-1-chloro-5-Methyl-, hydrochloride, (3S)- (9CI);(S)-3-Amino-1-chloro-5-methyl-2-hexanone hydrochloride;Leu-CMK HCl;L-Leu-CMK·HCl;H-LEU-CHLOROMETHYLKETONE HCL;H-LEU-CMK HCL
    3. CAS NO:54518-92-2
    4. Molecular Formula: C7H14ClNO*ClH
    5. Molecular Weight: 200.11
    6. EINECS: N/A
    7. Product Categories: Amino Acids;I - Z;Modified Amino Acids
    8. Mol File: 54518-92-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -15°C
    8. Solubility: N/A
    9. CAS DataBase Reference: L-LEUCINE CHLOROMETHYL KETONE HYDROCHLORIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: L-LEUCINE CHLOROMETHYL KETONE HYDROCHLORIDE(54518-92-2)
    11. EPA Substance Registry System: L-LEUCINE CHLOROMETHYL KETONE HYDROCHLORIDE(54518-92-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 54518-92-2(Hazardous Substances Data)

54518-92-2 Usage

Chemical Properties

White solid

Uses

L-Leucine chloromethyl ketone HCl

Biochem/physiol Actions

L-Leucine chloromethyl ketone (Leu-CMK) is used as a lysosomal cysteine protease inhibitor and as an insulin-like stimulator of lipid synthesis. L-Leucine chloromethyl ketone (Leu-CMK) may be acetylated to generate acetylleucine chloromethyl ketone, an inhibitor of acylpeptide hydrolase.

Check Digit Verification of cas no

The CAS Registry Mumber 54518-92-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,5,1 and 8 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 54518-92:
(7*5)+(6*4)+(5*5)+(4*1)+(3*8)+(2*9)+(1*2)=132
132 % 10 = 2
So 54518-92-2 is a valid CAS Registry Number.

54518-92-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-3-Amino-1-chloro-5-methylhexan-2-one hydrochloride

1.2 Other means of identification

Product number -
Other names L-LEUCINE CHLOROMETHYL KETONE HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:54518-92-2 SDS

54518-92-2Relevant articles and documents

Amino acids and peptides. XLI. Facile synthesis of 5-methyl-2(1H)-pyrazinone derivatives from dipeptidyl chloromethyl ketones

Taguchi,Yokoi,Tsukatani,Okada

, p. 7361 - 7372 (2007/10/02)

5-Methyl-2(1H)-pyrazinone derivatives were easily synthesized by short reflux of dipeptidyl chloromethyl ketone hydrochlorides in MeOH.

Amino acids and peptides. XXXVI. Synthesis of enkephalin chloromethyl ketone and evaluation of its inhibitory activity against endopeptidase 22.19

Taguchi,Nishiyama,Camargo,Okada

, p. 2038 - 2039 (2007/10/02)

Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl was synthesized by the conventional solution method. During the course of acid hydrolysis (6N HCl, 110°C, 18h) of Boc-Phe-Leu-CH2Cl, side reaction occurred, resulting in low recovery of Phe residue on amino acid analysis. The inhibitory activity of the synthesized Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl against endopeptidase 22.19, an enzyme related to the metabolism of opioid peptides, was examined.

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