102123-85-3 Usage
General Description
BOC-LEU-CHLOROMETHYLKETONE is a chemical compound that consists of a BOC (tert-butyloxycarbonyl) protecting group attached to the amino acid leucine, with a chloromethylketone functional group. BOC is commonly used in the protection of amines in organic chemistry, while leucine is one of the 20 natural amino acids that form proteins in living organisms. The chloromethylketone moiety is a reactive functional group that can covalently bind to the active site of proteolytic enzymes, inhibiting their activity. This chemical compound is often used as a research tool in the study of proteases and their biological functions, as well as in the development of potential therapeutic agents for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 102123-85-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,1,2 and 3 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 102123-85:
(8*1)+(7*0)+(6*2)+(5*1)+(4*2)+(3*3)+(2*8)+(1*5)=63
63 % 10 = 3
So 102123-85-3 is a valid CAS Registry Number.
102123-85-3Relevant articles and documents
Amino acids and peptides. XXXVI. Synthesis of enkephalin chloromethyl ketone and evaluation of its inhibitory activity against endopeptidase 22.19
Taguchi,Nishiyama,Camargo,Okada
, p. 2038 - 2039 (2007/10/02)
Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl was synthesized by the conventional solution method. During the course of acid hydrolysis (6N HCl, 110°C, 18h) of Boc-Phe-Leu-CH2Cl, side reaction occurred, resulting in low recovery of Phe residue on amino acid analysis. The inhibitory activity of the synthesized Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl against endopeptidase 22.19, an enzyme related to the metabolism of opioid peptides, was examined.
