54848-86-1Relevant articles and documents
A convergent and straightforward synthetic method to prepare deaza-analogs of squalene epoxidase inhibitors
Gotteland, Jean-Pierre,Guilhem, Marie-Christine,Halazy, Serge
, p. 2925 - 2934 (1996)
A general route to deaza-analogs of squalene epoxidase inhibitors of general formula A is described using a very convergent synthetic scheme illustrated by the preparation of compound 2b. A Heck reaction, and an enolate condensation with an appropriate electrophile are the key steps of the expedient elaboration of 2b or analogs.