176100-05-3Relevant academic research and scientific papers
Design and synthesis of new hypocholesterolemic organosilanes with antioxidant properties
Gotteland,Delhon,Junquero,Oms,Halazy
, p. 533 - 538 (2007/10/03)
(Arylamino)methylsilane derivatives 3 have been prepared and identified as potent inhibitors of human LDL oxidation mediated by copper(II). Combination of this property with the structural requirement of squalene epoxidase inhibitors led to the design and synthesis of the (arylamino)methylsilane derivative 4 which was characterised as the first potent, orally active squalene epoxidase inhibitor with antioxidant properties.
