548765-13-5Relevant articles and documents
Unexpected synthesis of 4-R-phenylallylidene Meldrum's acid derivatives
Insuasty, Braulio,Torres, Harlen,Abonia, Rodrigo,Quiroga, Jairo,Low, John,Sanchez, Adolfo,Cobo, Justo,Nogueras, Manuel
, p. 55 - 60 (2005)
Six novel cinnamylidene Meldrum's acid derivatives 3 have been obtained from the reaction of benzaldehydes 1 and Meldrum's acid 2, by heating under reflux in 2-ethoxyethanol and catalytic amounts of triethylamine. Analysis of the NMR-bidimensional experim
Bentonite catalyzed an efficient and green synthesis of arylidene meldrum's acid derivatives in aqueous media
Yahyazadehfar, Mahdieh,Ahmadi, Sayed Ali,Sheikhhosseini, Enayatollah,Ghazanfari, Dadkhoda
, p. 513 - 519 (2021/07/25)
In the present paper, a simple, highly efficient, and environmentally friendly protocol was proposed for the Knoevenagel condensation reaction of aromatic aldehydes using Meldrum’s acid (2,2-dimethyl-4,6-dioxo-1,3-dioxane) with bentonite as an available n
Microwave-associate synthesis of Co3O4 nanoparticles as an effcient nanocatalyst for the synthesis of arylidene barbituric and Meldrum's acid derivatives in green media
Yahyazadehfar, Mahdieh,Sheikhhosseini, Enayatollah,Ahmadi, Sayed Ali,Ghazanfari, Dadkhoda
, (2019/08/02)
In this study, Co3O4 nanocatalysts were constructed in environmentally appropriate conditions using controlled, effective, and facile microwave method. The final nanostructures were characterized by SEM, XRD, and TEM analyses. The products had a small size distribution, homogeneous morphology, and crystallographic structures associated with the formation of Co3O4 nanostructures. Moreover, EDS mapping analysis confirmed the existence of Co and O elements in the final structure, and the magnetic properties of the samples were investigated by VSM. The application of this nanostructure in a catalytic process was further examined, and the results suggested that it could be used as a novel candidate for the synthesis of arylidene barbituric and Meldrum,s acid through Knoevenagel condensation of aldehydes by barbituric and Meldrum,s acid in aqueous media. The high yield of these nanocatalysts would be justified by the nature of the nanostructure as well as the experimental procedure developed in this study, which affected the physicochemical features of the products.
A practical and convenient protocol for the synthesis of (E)-α,β-unsaturated acids
Mohite, Amar R.,Bhat, Ramakrishna G.
supporting information, p. 4564 - 4567 (2013/09/24)
α,β-Unsaturated acids are very useful and versatile reagents in organic synthesis. A novel, practical, and convenient catalytic protocol comprising FeCl3·6H2O (0.5 mol %) and H 2O (1 equiv) in CH3NO2 is described for the rapid synthesis of α,β-unsaturated acids with high E-stereoselectivity under both microwave and conventional heating conditions with high TON and TOF values. This powerful approach efficiently demonstrated the utility of biomass derived aldehydes to build chemical agents used as fuel additives. The method proved to be scalable to gram scale synthesis.
Oxidative and enantioselective cross-coupling of aldehydes and nitromethane catalyzed by diphenylprolinol silyl ether
Hayashi, Yujiro,Itoh, Takahiko,Ishikawa, Hayato
supporting information; experimental part, p. 3920 - 3924 (2011/05/15)
Synthetically important β-substituted γ-nitro aldehydes have been synthesized with excellent enantioselectivity by the cross-coupling reaction of β-aryl substituted aldehydes or Y γ-unsaturated aldehydes and nitromethane using 2,3-dichloro-5,6-dicyanoquinone (DDQ) and diphenylprolinol silyl ether as an oxidant and catalyst, respectively (see scheme; TMS=trimethylsilyl).
Lewis base-promoted hydrosilylation of cyclic malonates: Synthesis of β-substituted aldehydes and γ-substituted amines
Frost, Christopher G.,Hartley, Benjamin C.
supporting information; experimental part, p. 3599 - 3602 (2009/09/05)
The Lewis base-promoted hydrosilylation of cyclic malonates provides a convenient synthesis of β-substituted aldehydes. No over-reduction to the primary alcohol is observed as the aldehyde functionality is protected until a subsequent hydrolysis step. The
A general and practical preparation of alkylidene Meldrum's acids
Dumas, Aaron M.,Seed, Adam,Zorzitto, Alexander K.,Fillion, Eric
, p. 7072 - 7074 (2008/03/11)
Although many methods have been reported for the Knoevenagel condensation of aldehydes and Meldrum's acid, most are not general or use unconventional reagents and conditions. We have found that alkylidene Meldrum's acids form readily in benzene solution u
A novel and green protocol for two-carbon homologation: A direct amino acid/K2CO3-catalyzed four-component reaction of aldehydes, active methylenes, Hantzsch esters and alkyl halides
Ramachary, Dhevalapally B.,Kishor,Ramakumar
, p. 651 - 656 (2007/10/03)
A novel and green approach for the two-carbon homologation of aldehydes using amino acid catalysis has been developed and further extended to the generation of pharmaceutically active cyano-esters via four-component reactions in one-pot.
Clean synthesis in water. Part 2: Uncatalysed condensation reaction of Meldrum's acid and aldehydes
Bigi, Franca,Carloni, Silvia,Ferrari, Leonetto,Maggi, Raimondo,Mazzacani, Alessandro,Sartori, Giovanni
, p. 5203 - 5205 (2007/10/03)
The environment-friendly condensation of Meldrum's acid and aromatic, heteroaromatic and hindered aliphatic aldehydes is performed carrying out the reaction in water at 75°C for 2 h, avoiding the addition of any catalyst.
