5513-40-6Relevant articles and documents
Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties
Kal?ic, Filip,Zgarbová, Michala,Hodek, Jan,Chalupsky, Karel,Dra?ínsky, Martin,Dvo?áková, Alexandra,Strmeň, Timotej,?ebestík, Jaroslav,Baszczyňski, Ond?ej,Weber, Jan,Mertlíková-Kaiserová, Helena,Janeba, Zlatko
, p. 16425 - 16449 (2021/11/16)
This study describes the discovery of novel prodrugs bearing tyrosine derivatives instead of the phenol moiety present in FDA-approved tenofovir alafenamide fumarate (TAF). The synthesis was optimized to afford diastereomeric mixtures of novel prodrugs in
Phosphorylation of Tyrosine and Tyr-Thr-Lys Tripeptide with Cyclohexylmethyl- and (Deuteromethyl)phosphonochloridates
Baygildiev, T. M.,Krylov, I. I.,Krylov, V. I.,Osipov, V. N.,Rodin, I. A.,Rybalchenko, I. V.,Yashkir, V. A.
, p. 619 - 623 (2020/07/02)
Abstract: Methods for phosphorylation of tyrosine and Tyr-Thr-Lys tripeptide with cyclohexylmethyl(deuteromethyl)phosphonochloridates have been developed. These products can be used as reference compounds in the analysis of blood plasma of patients presumably exposed to cyclohexylmethylphosphonofluoridate (cyclosarin) action. Conditions for the separation and purification of the synthesized intermediates by means of chromatography have been determined and optimized, allowing high-purity phosphorylated products at the final stage of the synthesis.
Synthesis method of O-[2]-[[tert-Butoxycarbonyl]amino]ethyl]-N-[fluorene methoxycarbonyl]-L-tyrosine
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Paragraph 0007; 0008, (2019/08/20)
The invention relates to a synthesis method of O-[2]-[[tert-Butoxycarbonyl]amino]ethyl]-N-[fluorene methoxycarbonyl]-L-tyrosine. The present invention mainly solves the technical problem of high scale-up production cost existing in the present synthesis m
Primary amino acid lithium salt as a catalyst for asymmetric Michael addition of isobutyraldehyde with β-nitroalkenes
Sato, Atsushi,Yoshida, Masanori,Hara, Shoji
supporting information; experimental part, p. 6242 - 6244 (2009/05/06)
Phenylalanine lithium salt was found to be an effective catalyst for asymmetric Michael addition of isobutyraldehyde with β-nitroalkenes to give quaternary carbon-containing nitroalkanes. The Royal Society of Chemistry.
Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents
Williams, Nichola H.,Harrison, John M.,Read, Robert W.,Black, Robin M.
, p. 627 - 639 (2008/03/13)
The organophosphorus nerve agents sarin, soman, cyclosarin and tabun phosphylate a tyrosine residue on albumin in human blood. These adducts may offer relatively long-lived biological markers of nerve agent exposure that do not 'age' rapidly, and which ar
A convenient preparation of dityrosine via Miyaura borylation-Suzuki coupling of iodotyrosine derivatives
Hutton, Craig A.,Skaff, Ojia
, p. 4895 - 4898 (2007/10/03)
Dityrosine has been prepared from 3-iodo-L-tyrosine derivatives by sequential Miyaura borylation and Suzuki coupling reactions. A tandem borylation-coupling protocol results in improved yields of the dityrosine derivatives. Suitable protecting group strat
Stereospecific synthesis of 4-carboxyphenylalanine and derivatives for use in Fmoc-based solid-phase peptide synthesis
Wang, Wei,Obeyesekere, Nihal U.,McMurray, John S.
, p. 6661 - 6664 (2007/10/03)
Starting from N(α)-benzyloxycarbonyl-L-tyrosine(O-triflate) benzyl ester, we have prepared enantiomerically pure 4-carboxyphenylalanine and 4-methoxycarbonylphenylalanine derivatives using palladium (0) catalyzed carbonylation reactions. These unnatural amino acids were suitably protected and were used in solid-phase peptide synthesis using the Fmoc/t-butyl approach.
MILD BASIC AND HIGHLY SELECTIVE HYDROLYSIS OF AN ARYL-ALKYL 1-H-PHOSPHONATE DIESTER: PREPARATION OF THE MONO-1-H-PHOSPHONYLATED DIPEPTIDE Z-Ser(OPO2H2)-Tyr(OH)NH2.
Kuyl-Yeheskiely, E.,Tromp, C.M.,Marel, G.A. van der,Boom, J.H. van
, p. 4461 - 4464 (2007/10/02)
Basic hydrolysis (pyridine-water) of a 2,2,2-trifluoroethyl tyrosinyl 1-H-phosphonate diester affords predominantly a 2,2,2-trifluoroethyl 1-H-phosphonate mono-ester and tyrosine.The latter finding has been applied to the synthesis of a dipeptide consisting of a 1-H-phosphonylated serine and a non-1-H-phosphonylated tyrosine moiety.
