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Cas Database

55357-38-5

55357-38-5

Identification

  • Product Name:Choline tosylate

  • CAS Number: 55357-38-5

  • EINECS:

  • Molecular Weight:275.369

  • Molecular Formula: C5H14NO.C7H7O3S;C12H21NO4S

  • HS Code:2923900090

  • Mol File:55357-38-5.mol

Synonyms:Choline 4-methylbenzenesulphonate salt;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:Cholinep-ToluenesulfonateSalt
  • Packaging:10g
  • Price:$ 385
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Hydroxy-N,N,N-trimethylethanaminium4-methylbenzenesulfonate 95+%
  • Packaging:100g
  • Price:$ 756
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Hydroxy-N,N,N-trimethylethanaminium4-methylbenzenesulfonate 95+%
  • Packaging:10g
  • Price:$ 135
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Hydroxy-N,N,N-trimethylethanaminium4-methylbenzenesulfonate 95+%
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  • Manufacture/Brand:Crysdot
  • Product Description:2-Hydroxy-N,N,N-trimethylethanaminium4-methylbenzenesulfonate 95+%
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:CHOLINE TOSYLATE 95.00%
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:CHOLINE TOSYLATE 95.00%
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:CHOLINE TOSYLATE 95.00%
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  • Manufacture/Brand:AK Scientific
  • Product Description:Cholinetosylate
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Relevant articles and documentsAll total 8 Articles be found

Synthesis of sulfur-containing cationic lipids of the 1,3-dioxolane type

Klykov,Serebrennikova

, p. 1547 - 1549 (1998)

A series of cationic acetal lipids containing different spacer and cationic groups were synthesized starting from 1,2-O-hexadecylidene-3-thioglycerol.

PHARMACEUTICAL COMPOSITIONS OF LIPOIC ACID CHOLINE ESTER SALTS AND METHODS OF TREATMENT USING SAME

-

Page/Page column 71-72, (2021/09/17)

The present disclosure provides salts of lipoic acid choline ester (LACE), crystalline forms thereof, and methods of use thereof. The present disclosure further provides pharmaceutical compositions of LACE salts and methods of use thereof.

Synthesis, physicochemical properties and biological activities of novel alkylphosphocholines with foscarnet moiety

Mrva, Martin,Bukovsky, Marián,Devínsky, Ferdinand,Garajová, Mária,Juhásová, Anna,Luká?, Milo?,Moj?i?, Ján,Moj?i?ová, Gabriela,Pisár?ik, Martin,Timko, Luká?

, (2020/09/07)

A series of alkylphosphocholines with foscarnet moiety was synthesized. The structure of these zwitterionic amphiphiles was modified in both polar and non-polar parts of surfactant molecule. Investigations of physicochemical properties are represented by the determination of critical micelle concentration, the surface tension value at the cmc and the surface area per surfactant head group utilising surface tension measurements. Hydrodynamic diameter of surfactant micelles was determined using the dynamic light scattering technique. Alkylphosphocholines exhibit significant cytotoxic, anticandidal (Candida albicans) and antiamoebal (Acanthamoeba spp. T4 genotype) activity. The relationship between the structure, physicochemical properties and biological activity of the tested compounds revealed that lipophilicity has a significant influence on biological activity of the investigated surfactants. More lipophilic alkylphosphocholines with octadecyl chains show cytotoxic activity against cancer cells which is higher than that of the compounds with shorter alkyl chains. The opposite situation was observed in case of anticandidal and antiamoebal activity of these surfactants. The most active compounds were found to have pentadecyl chains. The foscarnet analogue of miltefosine C15-PFA-C showed the highest anticandidal activity. The minimum value of anticandidal activity of this compound is 1,4 μM thus representing the highest anticandidal activity found within the group of alkylphosphocholines.

Environment-friendly choline ionic liquid and preparation method therefor

-

Paragraph 0031; 0032; 0033; 0034; 0035; 0036, (2016/10/20)

The invention relates to environment-friendly novel choline ionic liquid and a method for preparing the choline ionic liquid. The novel choline ionic liquid contains levulinic acid choline, sorbic acid choline, glutaric acid choline, adipic acid choline, (p-, m- and o-)phthalic acid choline, trifluoromethanesulfonic acid choline, benzenesulfonic acid choline, (p-, m- and o-)toluenesulfonic acid choline, bis(trifluoromethane sulfonimide) choline and the like. The novel choline ionic liquid has the remarkable advantages that the preparation process is simple, the recovery is simple and convenient, the stability of reuse is good, and the like.

The silane compound surface modification material phosphorylcholine-

-

Paragraph 0017, (2018/06/29)

PROBLEM TO BE SOLVED: To provide a novel compound serving as a surface modifying material for a high sensitivity biosensing element, which enables forming of a monomolecular film capable of inhibiting nonspecific adsorption of protein. SOLUTION: The compound is a phosphorylcholine-silane compound represented by chemical formula 1, wherein X1to X3each independently represent halogen, 1-3C alkoxy or 1-3C alkyl, provided that at least one of X1to X3is halogen or 1-3C alkoxy; R1represents -(CH2)m- or -(CH2CH2O)n-(CH2)2-; R2represents -(CH2)s- or -(CH2)3-(OCH2CH2)p-; m is an integer of 2-20, n is an integer of 1-5, s is an integer of 3-20, and p is an integer of 1-5. COPYRIGHT: (C)2013,JPOandINPIT

Synthesis of phosphorylcholine-oligoethylene glycol-alkane thiols and their suppressive effect on non-specific adsorption of proteins

Tanaka, Mutsuo,Sawaguchi, Takahiro,Sato, Yukari,Yoshioka, Kyoko,Niwa, Osamu

supporting information; experimental part, p. 4092 - 4095 (2009/12/01)

A series of phosphorylcholine-oligoethylene glycol-alkane thiols were synthesized, and their suppressive effect on the non-specific adsorption of proteins was evaluated by comparison with corresponding oligoethylene glycol-alkane thiols. It was found that

Process route upstream and downstream products

Process route

2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

methyl p-toluene sulfonate
80-48-8

methyl p-toluene sulfonate

choline tosylate
55357-38-5

choline tosylate

Conditions
Conditions Yield
In toluene; 1.) 100 deg C, 1 h, 2.) 20 deg C, 20 h;
100%
In acetone; at 25 ℃; for 23h;
99%
In tetrahydrofuran; at 20 ℃; for 24h;
95%
In tetrahydrofuran; at 20 ℃; for 24h;
95%
In acetonitrile; for 4h; Reflux;
94%
In acetonitrile; for 4h; Reflux;
93.8%
In acetone; at 20 ℃;
81%
choline tosylate
55357-38-5

choline tosylate

Conditions
Conditions Yield
With sodium hydroxide; In ethanol; at 40 ℃; for 4h;
In ethanol; at 0 - 75 ℃; for 5.5h;
choline tosylate
55357-38-5

choline tosylate

1,2-dipalmitoyl-rac-glycero-3-phosphatidylcholine
2644-64-6,2797-68-4

1,2-dipalmitoyl-rac-glycero-3-phosphatidylcholine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: POCl3
2: 83 percent / 1-methylimidazole; 2,6-dichlorobenzoyl chloride / CH2Cl2 / 13 h / 20 °C
With 1-methyl-1H-imidazole; 2,6-Dichlorobenzoyl chloride; trichlorophosphate; In dichloromethane;
choline tosylate
55357-38-5

choline tosylate

dimyristoylphosphatidylcholine
18194-24-6

dimyristoylphosphatidylcholine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: pyridine / CHCl3 / Ambient temperature
2: 10percent aq. NaHCO3 / CHCl3 / Ambient temperature
With pyridine; sodium hydrogencarbonate; In chloroform;
rac-1,2-dipalmitoylglycerol
1042289-75-7

rac-1,2-dipalmitoylglycerol

choline tosylate
55357-38-5

choline tosylate

1,2-dipalmitoyl-rac-glycero-3-phosphatidylcholine
2644-64-6,2797-68-4

1,2-dipalmitoyl-rac-glycero-3-phosphatidylcholine

Conditions
Conditions Yield
rac-1,2-dipalmitoylglycerol; With triethylamine; trichlorophosphate; In chloroform; at 10 ℃; for 4.5h; Inert atmosphere;
choline tosylate; With pyridine; In chloroform; for 15.5h; Inert atmosphere;
55.1%
1-Hexadecanol
36653-82-4,124-29-8

1-Hexadecanol

choline tosylate
55357-38-5

choline tosylate

hexadecylphosphocholine
58066-85-6

hexadecylphosphocholine

Conditions
Conditions Yield
1-Hexadecanol; With triethylamine; trichlorophosphate; In chloroform; at 0 - 20 ℃;
choline tosylate; With pyridine; In chloroform; at 0 - 20 ℃;
With water; In chloroform; at 20 ℃; for 1h;
17.2%
choline tosylate
55357-38-5

choline tosylate

C<sub>39</sub>H<sub>71</sub>Cl<sub>2</sub>O<sub>6</sub>P

C39H71Cl2O6P

dioleoylphosphatidylcholine
4235-95-4

dioleoylphosphatidylcholine

Conditions
Conditions Yield
With pyridine; In chloroform; for 14h; Yield given; Ambient temperature;
choline tosylate
55357-38-5

choline tosylate

L-dipalmitoylphosphatidylcholine
63-89-8

L-dipalmitoylphosphatidylcholine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 1.) tetrazole / 1.) vacuum, 1 h, 2.) CH3CN, THF, 30 min
2: t-butyl hydroperoxide / toluene / 10 h / Ambient temperature
3: Me3N / toluene / 10 h / Ambient temperature
With 1H-tetrazole; tert.-butylhydroperoxide; trimethylamine; In toluene;
choline tosylate
55357-38-5

choline tosylate

triethylammonium 1,2-di-O-hexadecanoyl-sn-glycerol 3-hydrogenphosphonate
147632-69-7

triethylammonium 1,2-di-O-hexadecanoyl-sn-glycerol 3-hydrogenphosphonate

L-dipalmitoylphosphatidylcholine
63-89-8

L-dipalmitoylphosphatidylcholine

Conditions
Conditions Yield
With pyridine; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; water; iodine; Yield given. Multistep reaction; 2.) 5 min;
Conditions
Conditions Yield
1,2-dioleoylglycerol; With triethylamine; trichlorophosphate; In chloroform; at 10 ℃; for 4.5h; Inert atmosphere;
choline tosylate; With pyridine; In chloroform; for 15.5h; Inert atmosphere;
53.2%

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