571187-03-6

Basic information

• Product Name: 6-METHYL-N'-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE
• Synonyms: 6-METHYL-N'-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE;4-Methyl-N1-(4-(pyridin-3-yl)pyriMidin-2-yl)benzene-1,3-diaMine
• CAS NO: 571187-03-6
• Molecular Formula: C₁₆H₁₅N₅
• Molecular Weight: 277.32
• Mol File: 571187-03-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 542.773 °C at 760 mmHg
• Flash Point: 282.059 °C
• Appearance: /
• Density: 1.266 g/cm³
• Vapor Pressure: 7.65E-12mmHg at 25°C
• Refractive Index: 1.688
• CAS DataBase Reference: 6-METHYL-N'-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYL-N'-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE(571187-03-6)
• EPA Substance Registry System: 6-METHYL-N'-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE(571187-03-6)

Safety Data

• Hazardous Substances Data: 571187-03-6(Hazardous Substances Data)

Usage

General Description

6-Methyl-N'-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine is a chemical compound commonly known as MK-2206. It is a selective allosteric inhibitor of Akt, a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes, including cell proliferation, survival, and metabolism. MK-2206 has shown promise as a potential anticancer agent, particularly in the treatment of solid tumors with aberrant Akt signaling. It functions by binding to the PH domain of Akt and inhibiting its activation, ultimately leading to the suppression of tumor growth and survival. Research continues to explore the therapeutic potential of MK-2206 in various cancer types and as a component of combination treatments for improved efficacy.

InChI:InChI=1/C16H15N5/c1-11-4-5-13(9-14(11)17)20-16-19-8-6-15(21-16)12-3-2-7-18-10-12/h2-10H,17H2,1H3,(H,19,20,21)

Upstream product

• 796738-67-5 N,N-(4-methyl-3-nitrophenyl)[4-(pyridin-3-yl)-pyrimidin-2-yl]amine 
• 55314-16-4 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 
• 796738-68-6 N₁-amino(imino)methyl-4-methyl-3-nitroaniline nitrate 
• 350-03-8 methyl-3-pyridylketone 
• 99-55-8 2-methyl-5-nitroaniline 
• 152460-07-6 1-(2-methyl-5-nitrophenyl)guanidine 

Downstream Products

• 1427066-92-9 methyl 4-({2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylimino}methyl)benzoate 
• 1427066-95-2 methyl 4-(2-methyl-3-{5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenylamino}methyl)benzoate 
• 1399843-23-2 maleopimaric acid N-{2-methyl-5-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl}amide 
• 152459-95-5 imatinib 
• 1207534-84-6 N-[2-methyl-5-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-4-chloro-3-nitrobenzamide 
• 1207534-94-8 N-[2-methyl-5-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-4-methyl-3-nitrobenzamide 
• 1207534-96-0 N-[2-methyl-5-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-3-nitrobenzamide 
• 1207534-82-4 N-[2-methyl-5-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-2-chloro-4-nitrobenzamide 
• 1207534-97-1 N-[2-methyl-5-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]benzamide 
• 1207534-95-9 N-[2-methyl-5-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-2-methyl-5-nitrobenzamide 
• 1207534-80-2 N-[2-methyl-5-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-2-fluoro-5-nitrobenzamide 
• 1207534-79-9 N-[2-methyl-5-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-4-fluoro-3-nitrobenzamide 
• 1207534-93-7 N-[2-methyl-5-(4-pyridin-3-ylpyrimidin-2-ylamino)phenyl]-2-methyl-3-nitrobenzamide 
• 796738-69-7 N-(5-(4-chloromethylbenzoylamino)-4-methylphenyl)-4-(pyridin-3-yl)-2-pyrimidine-amine 

Relevant articles and documents

Catalytic Activity of Nickel Nanoparticles in the Reaction of Reduction of Nitroarenes

Techniques for the production of nickel and nickel-cobalt nanoparticles and of their composites with polyvinylpyrrolidone were developed. The catalytic activity of the resulting compounds towards reduction of substituted nitroarenes was examined.

Functionally substituted Schiff bases in reduction reactions

Functionally substituted Schiff bases obtained by the condensation of nitroaniline, pyrimidinylaminoaniline, 5-aminoquinoline, 5-aminoquinaldine derivatives with 4-methylformylbenzoate were studied in the reactions of sodium borohydride with acidic activators, hydrazine hydrate in the presence of Raney nickel, Raney alloy in the presence of potassium hydroxide. By the reduction of azomethines new benzyl derivatives of aniline, quinolylamine, arylaminopyrimidine, and phenylenediamine were obtained.

N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof

The present invention relates to an N-phenyl-2-pyrimidine-amine derivative showing a superior effect on lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, or cervical cancer, etc. of warm-blooded animals and its salt. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.