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5813-89-8

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5813-89-8 Usage

Description

2-Thiophenecarboxamide is a white crystalline powder with chemical properties that make it a potential candidate for use as a small molecule modulator. It specifically targets the β (nucleotide binding) domain of DnaK, a protein involved in bacterial stress response and heat shock response, which makes it a promising compound in the development of new antibacterial agents.

Uses

Used in Pharmaceutical Industry:
2-Thiophenecarboxamide is used as an antibacterial agent for its potential to modulate the DnaK protein, which plays a crucial role in bacterial stress response and heat shock response. By targeting this protein, 2-Thiophenecarboxamide may help in the development of new treatments against bacterial infections, particularly those that are resistant to conventional antibiotics.
Additionally, due to its small molecule nature, 2-Thiophenecarboxamide could be used in the development of drug delivery systems to improve the bioavailability and efficacy of antibacterial treatments. This application could be particularly useful in overcoming the limitations of current antibiotics and addressing the growing issue of antibiotic resistance.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 2779, 1951 DOI: 10.1021/ja01150a103

Check Digit Verification of cas no

The CAS Registry Mumber 5813-89-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,1 and 3 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5813-89:
(6*5)+(5*8)+(4*1)+(3*3)+(2*8)+(1*9)=108
108 % 10 = 8
So 5813-89-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H5NOS/c6-5(7)4-2-1-3-8-4/h1-3H,(H2,6,7)

5813-89-8 Well-known Company Product Price

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  • Alfa Aesar

  • (A15219)  Thiophene-2-carboxamide, 99%   

  • 5813-89-8

  • 5g

  • 401.0CNY

  • Detail
  • Alfa Aesar

  • (A15219)  Thiophene-2-carboxamide, 99%   

  • 5813-89-8

  • 25g

  • 1443.0CNY

  • Detail
  • Aldrich

  • (164453)  2-Thiophenecarboxamide  99%

  • 5813-89-8

  • 164453-5G

  • 466.83CNY

  • Detail

5813-89-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Thiophenecarboxamide

1.2 Other means of identification

Product number -
Other names 2-THIOPHENECARBOXAMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5813-89-8 SDS

5813-89-8Relevant articles and documents

Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens

Varakala, Saiprasad Dasugari,Reshma, Rudraraju Srilakshmi,Schnell, Robert,Dharmarajan, Sriram

, (2021/11/26)

Our previous studies on FabG have identified two compounds 5-bromo-2-(thiophene-2-carboxamido) benzoic acid (A) and ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate(B) as best hits with allosteric mode of inhibition. FabG is an integral part of bacterial fatty acid biosynthetic system FAS II shown to be an essential gene in most ESKAPE Pathogens. The current work is focussed on lead expansion of these two hit molecules which ended up with forty-three analogues (twenty-nine analogues from lead compound A and fourteen compounds from lead compound B). The enzyme inhibition studies revealed that compound 15 (effective against EcFabG, AbFabG, StFabG, MtFabG1) and 19 (inhibiting EcFabG and StFabG) had potency of broad-spectrum inhibition on FabG panel.

Nitrogen Atom Transfer Catalysis by Metallonitrene C?H Insertion: Photocatalytic Amidation of Aldehydes

Schmidt-R?ntsch, Till,Verplancke, Hendrik,Lienert, Jonas N.,Demeshko, Serhiy,Otte, Matthias,Van Trieste, Gerard P.,Reid, Kaleb A.,Reibenspies, Joseph H.,Powers, David C.,Holthausen, Max C.,Schneider, Sven

, (2022/01/20)

C?H amination and amidation by catalytic nitrene transfer are well-established and typically proceed via electrophilic attack of nitrenoid intermediates. In contrast, the insertion of (formal) terminal nitride ligands into C?H bonds is much less developed and catalytic nitrogen atom transfer remains unknown. We here report the synthesis of a formal terminal nitride complex of palladium. Photocrystallographic, magnetic, and computational characterization support the assignment as an authentic metallonitrene (Pd?N) with a diradical nitrogen ligand that is singly bonded to PdII. Despite the subvalent nitrene character, selective C?H insertion with aldehydes follows nucleophilic selectivity. Transamidation of the benzamide product is enabled by reaction with N3SiMe3. Based on these results, a photocatalytic protocol for aldehyde C?H trimethylsilylamidation was developed that exhibits inverted, nucleophilic selectivity as compared to typical nitrene transfer catalysis. This first example of catalytic C?H nitrogen atom transfer offers facile access to primary amides after deprotection.

Single-pot tandem oxidative/C-H modification amidation process using ultrasmall PdNP-encapsulated porous organosilica nanotubes

Gholipour, Behnam,Liu, Xiao,Rostamnia, Sadegh,Zonouzi, Afsaneh

, p. 4276 - 4287 (2022/02/16)

Herein, we studied a single-pot method with a dual catalysis process towards the conversion of primary aromatic alcohols to amides using ultrasmall PdNPs of controlled uniform size (1.8 nm) inside hybrid mesoporous organosilica nanotubes (MO-NTs). The cat

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