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5813-89-8

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5813-89-8 Usage

Description

2-Thiophenecarboxamide is a white crystalline powder with chemical properties that make it a potential candidate for use as a small molecule modulator. It specifically targets the β (nucleotide binding) domain of DnaK, a protein involved in bacterial stress response and heat shock response, which makes it a promising compound in the development of new antibacterial agents.

Uses

Used in Pharmaceutical Industry:
2-Thiophenecarboxamide is used as an antibacterial agent for its potential to modulate the DnaK protein, which plays a crucial role in bacterial stress response and heat shock response. By targeting this protein, 2-Thiophenecarboxamide may help in the development of new treatments against bacterial infections, particularly those that are resistant to conventional antibiotics.
Additionally, due to its small molecule nature, 2-Thiophenecarboxamide could be used in the development of drug delivery systems to improve the bioavailability and efficacy of antibacterial treatments. This application could be particularly useful in overcoming the limitations of current antibiotics and addressing the growing issue of antibiotic resistance.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 2779, 1951 DOI: 10.1021/ja01150a103

Check Digit Verification of cas no

The CAS Registry Mumber 5813-89-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,1 and 3 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5813-89:
(6*5)+(5*8)+(4*1)+(3*3)+(2*8)+(1*9)=108
108 % 10 = 8
So 5813-89-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H5NOS/c6-5(7)4-2-1-3-8-4/h1-3H,(H2,6,7)

5813-89-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Alfa Aesar

  • (A15219)  Thiophene-2-carboxamide, 99%   

  • 5813-89-8

  • 5g

  • 401.0CNY

  • Detail
  • Alfa Aesar

  • (A15219)  Thiophene-2-carboxamide, 99%   

  • 5813-89-8

  • 25g

  • 1443.0CNY

  • Detail
  • Aldrich

  • (164453)  2-Thiophenecarboxamide  99%

  • 5813-89-8

  • 164453-5G

  • 466.83CNY

  • Detail

5813-89-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Thiophenecarboxamide

1.2 Other means of identification

Product number -
Other names 2-THIOPHENECARBOXAMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5813-89-8 SDS

5813-89-8Relevant articles and documents

Mechanochemical synthesis of half-sandwich iridium/rhodium complexes with 8-hydroxyquinoline derivatives ligands

Jia, Wei-Guo,Li, Xiao-Dong,Zhi, Xue-Ting,Zhong, Rui

, (2022/01/19)

Mechanochemistry provides a rapid, efficient route to half-sandwich iridium and rhodium complexes from [MCp*(μ-Cl)Cl]2 (M = Ir, Rh) and 8-hydroxyquinoline-2-carbaldehyde without the need for Schlenk manipulation, inert gas protection, or dry solvents. Furthermore, post-synthetic modification of the half-sandwich metal complexes has been carried out via a mechanochemical Wittig reaction between half-sandwich metal complex and phosphorus ylide. All complexes were fully characterized by 1H and 13C NMR spectra, infrared spectroscopy, mass spectrometry, and single-crystal X-ray diffraction method. The half-sandwich rhodium complexes exhibited high catalytic activity towards the amide synthesis between aldehyde and hydroxylamine hydrochloride (NH2OH·HCl) with a broad functional group tolerance.

Sustainable synthesis of drug intermediates via simultaneous utilization of carbon monoxide and ammonia over Pd@La-MOF

Bhattacharya, Sumantra,Bordoloi, Ankur,Das, Subhasis,Gazi, Jahiruddin,Islam, Sk Manirul,Prasad, V. V. D. N.,Sengupta, Manideepa

, (2022/03/14)

Mitigation of carbon monoxide and ammonia to valuable primary aromatic amides is an imperative approach to control the environmentally harmful emissions thereby infusing towards sustainability. Designing of nanostructured catalyst for direct access to the synthetically valuable primary aromatic and heteroaromatic amides via carbonylative amination of aryl halides is always demanding since nano materials can bridge the gap between homogeneous and heterogeneous catalysis thus preserving the desirable attributes of both the systems towards sustainable catalysis. Herein, microwave assisted fabrication of highly uniform Pd NPs (3,4 nm) over La-MOFs has been performed and utilized efficiently for ligand free carbonylative amination of aryl iodides with carbon monoxide and ammonia. Moderate to high yields of benzamide derivatives, salicylamide, a drug having analgesic and antipyretic properties were achieved. The unsaturated metal sites in the MOF via synergistic mode of σ and π bonding binds with CO, which significantly enhances the catalytic activity of MOF-composite unlike other supported Pd NPs. DFT confirms the growth of pristine Pd13 cluster within the framework, as active metal center for the carbonylative amination.

A “universal” catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides

Bartling, Stephan,Beller, Matthias,Chandrashekhar, Vishwas G.,Jagadeesh, Rajenahally V.,Rabeah, Jabor,Rockstroh, Nils,Senthamarai, Thirusangumurugan

supporting information, p. 508 - 531 (2022/02/11)

Functionalized (hetero)aromatic compounds are indispensable chemicals widely used in basic and applied sciences. Among these, especially aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides represent valuable fine and bulk chemicals, which are used in chemical, pharmaceutical, agrochemical, and material industries. For their synthesis, catalytic aerobic oxidation of alcohols constitutes a green, sustainable, and cost-effective process, which should ideally make use of active and selective 3D metals. Here, we report the preparation of graphitic layers encapsulated in Co-nanoparticles by pyrolysis of cobalt-piperazine-tartaric acid complex on carbon as a most general oxidation catalyst. This unique material allows for the synthesis of simple, functionalized, and structurally diverse (hetero)aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides from alcohols in excellent yields in the presence of air.

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