59291-70-2

Basic information

• Product Name: dimethyl 3-(4-methoxyphenyl)isoxazole-4,5-dicarboxylate
• Synonyms: dimethyl 3-(4-methoxyphenyl)isoxazole-4,5-dicarboxylate
• CAS NO: 59291-70-2
• Molecular Weight: 291.26
• Mol File: 59291-70-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: dimethyl 3-(4-methoxyphenyl)isoxazole-4,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 3-(4-methoxyphenyl)isoxazole-4,5-dicarboxylate(59291-70-2)
• EPA Substance Registry System: dimethyl 3-(4-methoxyphenyl)isoxazole-4,5-dicarboxylate(59291-70-2)

Safety Data

• Hazardous Substances Data: 59291-70-2(Hazardous Substances Data)

Upstream product

• 947-57-9 dimethyl bicyclo[2.2.1]hept-2,5-diene-2,3-dicarboxylate 
• 15500-73-9 4-methoxybenzonitrile oxide 
• 19019-88-6 7-isopropylidene-2,3-dicarbomethoxynorbornadiene 
• 3717-21-3 p-methoxyl benzaldoxime 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 1829-60-3 dimethyl 7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate 
• 19279-26-6 1,3,2,4-dioxathiazole S-oxide 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 

Relevant articles and documents

Heterocycle-Heterocycle Strategy for 4,5-Disubstituted Pyrrolidine 2,3-Diones: Reductive Rearrangement Approach from Isoxazole Esters

The work demonstrates the heterocycle-heterocycle interconversion strategy to access 4,5-disubstituted 3-hydroxy-2-pyrrolidinone in moderate to good yields (50-80%). The approach has a distinct advantage over a multicomponent reaction approach as it allow

SITE SELECTIVITY IN THE REACTIONS OF 1,3-DIPOLES WITH NORBORNADIENE DERIVATIVES

The cycloadditions of arylazides, benzonitrile oxides and diphenylnitrile imine to norbornadiene derivatives 1a-c showed varying degree of site- and stereo-selectivity.With dipolarophile 1a arylazides and benzonitrile oxides attack, preferentially, the electron-poor tetrasubstituted double bond, while in the case of 1b and 1c is the substituted double bond which enters the cycloaddition.By contrast, 2-diazopropane and C-phenyl-N-methylnitrone react with the sole tetrasubstituted double bond of 1a-c in stereo- and site-specific cycloadditions.The quantitative evaluation of the two possible reaction paths was performed by glc analysis.The compounds detected were those arising from Diels-Alder cycloreversions of the thermally labile intermediate adducts 2 and 3 (Scheme 1).The results were rationalized on the basis of a qualitative perturbation treatment which considers frontier orbital interactions only.