15500-73-9

Usage

Uses

Used in Research and Laboratory Settings:
[(4-methoxyphenyl)methylidyne]azane oxide is used as a reagent for various applications in research and laboratory settings. It is particularly useful in organic synthesis and pharmaceutical research due to its unique chemical properties.
It is important to handle [(4-methoxyphenyl)methylidyne]azane oxide with care, as it may have certain health and safety considerations.

Upstream product

• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 3717-21-3 p-methoxyl benzaldoxime 
• 74903-79-0 N-hydroxy-4-methoxybenzenecarboximidoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 3717-21-3 (E)-4-methoxybenzaldoxime 

Downstream Products

• 3672-52-4 3-(4-methoxyphenyl)-5-phenylisoxazole 
• 54606-01-8 1-[3-(4-methoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-ethanone 
• 61428-15-7 3-(4-methoxy-phenyl)-5-nitro-4,5-dihydro-isoxazole 
• 61428-21-5 3-(4-methoxy-phenyl)-5-methylisoxazole 
• 56118-32-2 3-(4-methoxy-phenyl)-8b-pyrrolidin-1-yl-3a,8b-dihydro-benzo[4,5]furo[2,3-d]isoxazole 
• 54027-51-9 3-(4-methoxy-phenyl)-(3ar,7bc)-3a,7b-dihydro-benzo[3,4]cyclobuta[1,2-d]isoxazole 
• 54697-03-9 3,6-di(4-methoxyphenyl)-1,4,2,5-dioxadiazine 
• 188118-29-8 3,5-bis(4-methoxyphenyl)-1,2,4-oxadiazole 4-oxide 
• 26218-40-6 3,4-bis(4-methoxyphenyl)-1,2,5-oxadiazole-2-oxide 
• 59291-70-2 dimethyl 3-(4-methoxyphenyl)isoxazole-4,5-dicarboxylate 
• 110-00-9 furan 
• 61428-20-4 3-(4-methoxyphenyl)isoxazole 
• 4282-33-1 dimethyl 3,4-furandicarboxylate 
• 138638-56-9 N-[3-(4-Methoxy-phenyl)-[1,4,2]dioxazol-(5Z)-ylidene]-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Reactivity of arylnitrile oxides and C-aroyl-N-phenylnitrones with 3-methylenedihydro-(3H)-furan-2-one and itaconic anhydride

1,3-dipolar cycloaddition is a powerful route for the synthesis of five-membered heterocycles. The [3+2] cycloadditions of some α-methylene-γ-buryrolactones, namely 3-methylenedihydro-(3H)-furan-2-one (1) and itaconic anhydride (2) were studied. Their rea

1,3-Cycloaddition reactions of 2-oxo-2H-[1]benzopyran-4-carbonitrile N- oxide. Synthesis of several new 4-substituted coumarins

1,3-Cycloaddition reactions of new 2-oxo-2H-[1]benzopyran-4-carbonitrile N-oxide 2 with dipolarophiles, o-aminophenols and o-phenylenediamine resulted in 4-heterocyclic substituted coumarin derivatives. These derivatives are screened for antiinflammatory activity in vitro through their antiproteolytic activity, the interaction with 1,1-diphenyl-2-picrylhydrazyl and the ability to affect superoxide anion and to inhibit β-glucuronidase and soybean lipoxygenase.

Reaction of polyfluorinated cyclohexa-2,4-dienones with aryl nitrile oxides

Reaction of 1,3-dipolar cycloaddition of 6-chloropentafluorocyclohexa-2,4- dienone, 6-chloro-3-(pentafluorophenoxy)tetrafluorocyclohexa-2,4-dienone, and perfluoro-6-phenoxycyclohexa-2,4-dienone with aryl nitrile oxides proceeds highly stereoselectively at

1,3-Dipolar cycloaddition reactions of acyl phosphonates with nitrile oxides: synthesis of phosphonate-containing dioxazole derivatives

New phosphonate-containing five-membered heterocyclic dioxazole derivatives are synthesized via 1,3-dipolar cycloaddition reactions of nitrile oxides used as dipole with acyl phosphonates under basic conditions. Herein, acyl phosphonates take part in the

Regioselective [3+2] cycloaddition of nitrile oxides to 1Н-pyrrole-2,3-diones: synthesis of spiro[pyrroledioxazoles]

[Figure not available: see fulltext.] 1,3-Dipolar cycloaddition of 1H-pyrrole-2,3-diones to nitrile oxides generated in situ from N-hydroxybenzimidoyl chlorides by the action of triethylamine proceeds regioselectively with the formation of 1,4,2-dioxazole

One-Pot Regioselective Synthesis of 7-Bromo-2H-Benzo[b][1,4]Oxazin-3(4H)-One Linked Isoxazole Hybrids as Anti-Cancer Agents and Their Molecular Docking Studies

Abstract: Regioselective synthesis of some novel 7-bromo-2H-benzo[b][1,4]oxazin-3(4H)-one linked isoxazole hybrids via copper(I) catalyzed one-pot reaction of various aromatic aldehydes with 7-bromo-4-(prop-2-yn-1-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one was developed. The structures of the compounds that are synthesized are confirmed by 1H NMR, 13C NMR, and mass spectra. All the hybrids have been tested for their in vitro anticancer activity against four human cancer cell lines, including HeLa, MCF-7, A549, and PC3. Three of the compounds exhibited remarkable anticancer activity compared to standard drug etoposide. Molecular docking studies with EGFR also strengthened the in vitro anticancer activity.

One-pot Synthesis of Some Novel Xanthine Derived Isoxazoles as Potent Antibacterial Agents

In search of better antibacterial agents, a series of novel xanthine derived 3,5-disubstituted isoxazole derivatives were synthesized (3a-3j) in one-pot using 8-chloro-1,3-dimethyl-7-(prop-2-yn-1-yl)-1H-purine-2,6(3H,7H)-dione and aromatic aldehydes and f

One Pot Synthesis and Antitumor Activity of Isoxazole-Pyrimido[4,5-c]isoquinolines

Abstract: A number of new isoxazole coupled pyrimido[4,5-c]isoquinolines has been synthesized in good to excellent yields by the one pot method. The Cu(I)-catalyzed cycloaddition reaction between the terminal alkyne 4 and various aldehydes has led to nitr

Novel access to 2-substituted quinolin-4-ones by nickel boride-mediated reductive ring transformation of 5-(2-nitrophenyl)isoxazoles

Reductive ring transformation of 3-substituted 5-(2-nitrophenyl)isoxazoles, readily accessible via 1,3-dipolar cycloaddition of 2-ethinylnitrobenzene with nitrile oxides, opens a novel access to 2-substituted quinolin-4-ones. Nickel boride, generated in situ from nickel chloride and sodium borohydride, allows, via simultaneous reduction of the nitro group and reductive cleavage of the isoxazole ring, the one-step conversion into the target quinolin-4-ones. This protocol tolerates various functional groups, except olefins, and thus is complementary to the reductive ring transformation with iron/acetic acid, which predominantly tolerates olefins.

Cu(I)-Catalysis of One-Pot Synthesis of Some Novel Regioselective Isoxazole-Benzimidazole Hybrids and Their In Vitro Anti-Cancer Evaluation

Regioselective synthesis of some novel isoxazole-benzimidazole hybrids in high yields via Cu(I)-catalyzed tandem one-pot reaction of aromatic aldehydes with 1-prop-2-ynylbenzimidazole is developed. Structures of the synthesized compounds are confirmed by