Welcome to LookChem.com Sign In|Join Free

CAS

  • or

59865-15-5

Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A, characterized by its white solid chemical properties. Unlike cyclosporin A, it does not exhibit any immunosuppressant activity, making it a valuable control in determining the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.

59865-15-5 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 59865-15-5 Structure

  • Basic information

    1. Product Name: DIHYDROCYCLOSPORIN A
    2. Synonyms: DIHYDROCYCLOSPORIN A;Dihydrocyclosporin;(3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-];(3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A;Cyclosporin A Dihydro IMpurity;Dihydrocyclosporine A
    3. CAS NO:59865-15-5
    4. Molecular Formula: C62H113N11O12
    5. Molecular Weight: 1204.63
    6. EINECS: N/A
    7. Product Categories: Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
    8. Mol File: 59865-15-5.mol

  • Chemical Properties

    1. Melting Point: 120-125?C
    2. Boiling Point: 1285.277oC at 760 mmHg
    3. Flash Point: 731.109oC
    4. Appearance: /
    5. Density: 1.012g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.464
    8. Storage Temp.: Refrigerator
    9. Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
    10. PKA: 13.33±0.70(Predicted)
    11. CAS DataBase Reference: DIHYDROCYCLOSPORIN A(CAS DataBase Reference)
    12. NIST Chemistry Reference: DIHYDROCYCLOSPORIN A(59865-15-5)
    13. EPA Substance Registry System: DIHYDROCYCLOSPORIN A(59865-15-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 59865-15-5(Hazardous Substances Data)

59865-15-5 Usage

Uses

Used in Pharmaceutical Research:
Dihydrocyclosporin A is used as a control substance for [application reason] to determine the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.
Used in Immunosuppressive Drug Development:
As an analog of cyclosporin A, Dihydrocyclosporin A is used as a reference compound for [application type] in the development of new immunosuppressive drugs, aiding in understanding the differences in their mechanisms of action and potential therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 59865-15-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,8,6 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 59865-15:
(7*5)+(6*9)+(5*8)+(4*6)+(3*5)+(2*1)+(1*5)=175
175 % 10 = 5
So 59865-15-5 is a valid CAS Registry Number.
InChI:InChI=1/C62H113N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h34-47,49-52,75H,25-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/t40-,41+,42-,43+,44+,45+,46-,47+,49+,50+,51?,52-/m1/s1

59865-15-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Dihydro Cyclosporin A

1.2 Other means of identification

Product number -
Other names 6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59865-15-5 SDS

59865-15-5Downstream Products

59865-15-5Relevant articles and documents

Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives

Wei, Ling,Steiner, Joseph P.,Hamilton, Gregory S.,Wu, Yong-Qian

, p. 4549 - 4551 (2004)

In order to exploit cyclophilin as a potential target for neurological drug design, we demonstrate in this presentation that several nonimmunosuppressant analogues of cyclosporin A, modified at the various positions in the 'effector' domain, are equipotent nerve growth agents compared to cyclosporin A. Our results suggest that neurotrophic activity of cyclosporin A and its derivatives resides in the binding domain, and binding to cyclophilin and/or inhibiting rotamase activity may be a necessity for neurotrophic effects of cyclophilin ligands.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 59865-15-5