59883-07-7Relevant articles and documents
N-Heterocyclic carbene based catalytic platform for Hauser-Kraus annulations
Sharique, Mohammed,Tambar, Uttam K.
, p. 7239 - 7243 (2020/07/23)
The venerable Hauser-Kraus annulation is an effective and convergent method for generating oxygenated polycyclic aromatic compounds. Despite its application in complex molecule synthesis, the harsh and strongly basic conditions can limit its utility in more functionalized molecular settings. We have developed the first catalytic Hauser-Kraus annulation based on N-heterocyclic carbene catalysis that proceeds under milder conditions. We demonstrate the scope of the transformation in the presence of several functional groups. We also propose a concerted mechanism for the annulation that proceeds through a non-canonical Breslow intermediate. This journal is
NAPHTHALENE AND QUINOLINE SULFONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS
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Page/Page column 20-21, (2008/12/04)
The invention is directed to naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. Pharmaceutical compositions and methods of use are also included.
An Efficient Synthesis of p-Quinones utilizing a Novel Pummerer-type Rearrangement of p-Sulfinylphenols
Akai, Shuji,Takeda, Yoshifumi,Iio, Kiyosei,Yoshida, Yutaka,Kita, Yasuyuki
, p. 1013 - 1014 (2007/10/02)
Treatment of the p-sulfinylphenol derivatives 1 and 5 with trifluoroacetic anhydride causes a Pummerer-type rearrangement on aromatic rings and concomitant desulfurization to give 1:1 mixtures of the corresponding p-quinones and p-dihydroquinones, which are subjected to mild oxidation to provide high yields of p-quinones 3 and 7.