60079-51-8

Basic information

• Product Name: H-PHG-NH2 HCL
• Synonyms: PHENYLGLYCINE AMIDE HYDROCHLORIDE;PHENYLGLYCINE-NH2 HCL;H-PHG-NH2 HCL;H-L-PHG-NH2 HCL;L-PHENYLGLYCINE AMIDE HYDROCHLORIDE;L-PHENYLGLYCINE ESTER-ALPHA-AMIDE HYDROCHLORIDE;(S)-2-amino-2-phenylacetamide hydrochloride;(2S)-2-Amino-2-phenylethanamide hydrochloride
• CAS NO: 60079-51-8
• Molecular Formula: C₈H₁₀N₂O*ClH
• Molecular Weight: 186.64
• Mol File: 60079-51-8.mol

Chemical Properties

• Appearance: /Solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: H-PHG-NH2 HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHG-NH2 HCL(60079-51-8)
• EPA Substance Registry System: H-PHG-NH2 HCL(60079-51-8)

Safety Data

• Hazardous Substances Data: 60079-51-8(Hazardous Substances Data)

Usage

Uses

Used in Biochemistry Research:
H-PHG-NH2 HCL is used as a research compound for studying the properties and interactions of amino acids and peptides in biochemical processes. Its specific molecular weight, solubility, and stability in various conditions make it a valuable tool in understanding the behavior of dipeptides in biological systems.
Used in Molecular Genetics Research:
In molecular genetics, H-PHG-NH2 HCL serves as a component in the synthesis and analysis of genetic materials. Its specific composition and properties allow researchers to investigate the role of dipeptides in gene expression, regulation, and other genetic mechanisms.
Used in Academic Research:
H-PHG-NH2 HCL is utilized in academic research to explore the fundamental aspects of dipeptide chemistry, including their synthesis, structure, and reactivity. This knowledge contributes to the broader understanding of peptide chemistry and its applications in various fields.
Used in Industrial Research:
In industrial research, H-PHG-NH2 HCL is employed for the development of new products and processes that involve dipeptides. Its unique properties can be harnessed to create innovative solutions in areas such as pharmaceuticals, food science, and materials science.
Overall, H-PHG-NH2 HCL is a versatile chemical compound with a wide range of applications in both academic and industrial research settings, particularly in the fields of biochemistry and molecular genetics. Its specific properties and hydrochloride form make it an essential tool for studying and utilizing dipeptides in various experimental setups.

Upstream product

• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 
• 51703-58-3 (RS)-phenylglycinamide hydrochloride 
• 143978-92-1 Boc-L-Phg-NH₂ 

Downstream Products

• 6485-52-5 L-phenylglycine amide 
• 1342278-84-5 (S)-2-phenyl-2-(3-(4-(pyridin-4-yl)thiazol-2-yl)ureido)acetamide 
• 135911-83-0 {(1S,2S,4R)-1-Benzyl-4-[((S)-carbamoyl-phenyl-methyl)-carbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.

Design and synthesis of dipeptide nitriles as reversible and potent cathepsin S inhibitors

The specificity of the immune response relies on processing of foreign proteins and presentation of antigenic peptides at the cell surface. Inhibition of antigen presentation, and the subsequent activation of T-cells, should, in theory, modulate the immune response. The cysteine protease Cathepsin S performs a fundamental step in antigen presentation and therefore represents an attractive target for inhibition. Herein, we report a series of potent and reversible Cathepsin S inhibitors based on dipeptide nitriles. These inhibitors show nanomolar inhibition of the target enzyme as well as cellular potency in a human B cell line. The first X-ray crystal structure of a reversible inhibitor cocrystallized with Cathepsin S is also reported.

Process for the resolution of threo-3-[(2-aminophenyl)-thio]-2-hydroxy-3-(4-methoxy-phenyl)propionic acid

The invention relates to a novel process for the resolution of an acid mixture (hereinafter: threo acid mixture) containing (+)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propionic acid [hereinafter: (+)-threo acid]and (-)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propionic acid [hereinafter: (-)-threo acid].